NCT02441192

Brief Summary

Background. The cardiovascular and cardiorespiratory coupling (CVCRC), focusing to recognize the synergies of standard or modified physiology that promote healthy. The investigators aim to study the effects of different training modalities and detraining on CVCRC. Methods. 32 young males were distributed in four randomized training groups: aerobic (AT), resistance (RT), aerobic plus resistance (AT+RT) and control (C). They were tested before, after the training (6 weeks) and after the detraining (3 weeks) through a graded maximal test. A principal component (PC) analysis of the time series of selected cardiovascular and cardiorespiratory variables was performed to evaluate the CVCRC. The PC1 coefficient of congruence in the 3 experimental conditions (before, after training and after detraining) was calculated for each group.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
40

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Jan 2013

Typical duration for not_applicable

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2013

Completed
5 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2013

Completed
1.9 years until next milestone

First Submitted

Initial submission to the registry

April 28, 2015

Completed
3 days until next milestone

Study Completion

Last participant's last visit for all outcomes

May 1, 2015

Completed
11 days until next milestone

First Posted

Study publicly available on registry

May 12, 2015

Completed
Last Updated

June 11, 2015

Status Verified

June 1, 2015

Enrollment Period

5 months

First QC Date

April 28, 2015

Last Update Submit

June 10, 2015

Conditions

Keywords

physical trainingaerobic trainingresistance training

Outcome Measures

Primary Outcomes (1)

  • Cardiovascular and cardiorespiratory coupling by the principal component (PC) analysis

    A PC analysis of the time series of the following selected cardiorespiratory variables: expired fraction of O2 (FeO2), expired fraction of CO2 (FeCO2), ventilation (VE), systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate (HR) is performed to obtain information about the CVCRC in each participant. (The principal component (PC) analysis is a common statistical technique that has been used to recognize such coordinative variables) The median of PC1 coefficient of congruence was obtained in each group and condition (before, after training and detraining) to evaluate the dimensional changes of the CVCRC before and after a period of 6 weeks of different training modalities (AT, RT and AT+RT) and 3 weeks after detraining in healthy young men.

    3 months

Study Arms (3)

Training resistance

EXPERIMENTAL

After the baseline tests they were distributed in four randomized groups for the 6 weeks of training: aerobic (AT), resistance (RT), aerobic+resistance (AT+RT) and control (C).

Other: Training resistance

Training aerobic

EXPERIMENTAL

After the baseline tests they were distributed in four randomized groups for the 6 weeks of training: aerobic (AT), resistance (RT), aerobic+resistance (AT+RT) and control (C).

Other: Training aerobic

Training resistance+aerobic

EXPERIMENTAL

After the baseline tests they were distributed in four randomized groups for the 6 weeks of training: aerobic (AT), resistance (RT), aerobic+resistance (AT+RT) and control (C).

Other: Training resistance+aerobic

Interventions

After the baseline tests they were distributed in four randomized groups for the 6 weeks of training: aerobic (AT), resistance (RT), aerobic+resistance (AT+RT) and control (C).

Training resistance

After the baseline tests they were distributed in four randomized groups for the 6 weeks of training: aerobic (AT), resistance (RT), aerobic+resistance (AT+RT) and control (C).

Training aerobic

After the baseline tests they were distributed in four randomized groups for the 6 weeks of training: aerobic (AT), resistance (RT), aerobic+resistance (AT+RT) and control (C).

Training resistance+aerobic

Eligibility Criteria

Age18 Years - 26 Years
Sexmale
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • healthy physically active males
  • physical education students
  • signed an informed consent form

You may not qualify if:

  • No confirm their healthy status
  • No signed an informed consent form

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Publications (5)

  • Friedman L, Dick TE, Jacono FJ, Loparo KA, Yeganeh A, Fishman M, Wilson CG, Strohl KP. Cardio-ventilatory coupling in young healthy resting subjects. J Appl Physiol (1985). 2012 Apr;112(8):1248-57. doi: 10.1152/japplphysiol.01424.2010. Epub 2012 Jan 19.

    PMID: 22267392BACKGROUND
  • Garcia AJ 3rd, Koschnitzky JE, Dashevskiy T, Ramirez JM. Cardiorespiratory coupling in health and disease. Auton Neurosci. 2013 Apr;175(1-2):26-37. doi: 10.1016/j.autneu.2013.02.006. Epub 2013 Mar 13.

    PMID: 23497744BACKGROUND
  • Wu SD, Lo PC. Cardiorespiratory phase synchronization during normal rest and inward-attention meditation. Int J Cardiol. 2010 Jun 11;141(3):325-8. doi: 10.1016/j.ijcard.2008.11.137. Epub 2009 Jan 14.

    PMID: 19144415BACKGROUND
  • Braith RW, Stewart KJ. Resistance exercise training: its role in the prevention of cardiovascular disease. Circulation. 2006 Jun 6;113(22):2642-50. doi: 10.1161/CIRCULATIONAHA.105.584060. No abstract available.

    PMID: 16754812BACKGROUND
  • Pollock ML, Franklin BA, Balady GJ, Chaitman BL, Fleg JL, Fletcher B, Limacher M, Pina IL, Stein RA, Williams M, Bazzarre T. AHA Science Advisory. Resistance exercise in individuals with and without cardiovascular disease: benefits, rationale, safety, and prescription: An advisory from the Committee on Exercise, Rehabilitation, and Prevention, Council on Clinical Cardiology, American Heart Association; Position paper endorsed by the American College of Sports Medicine. Circulation. 2000 Feb 22;101(7):828-33. doi: 10.1161/01.cir.101.7.828. No abstract available.

    PMID: 10683360BACKGROUND

MeSH Terms

Conditions

Health Behavior

Interventions

Resistance Training

Condition Hierarchy (Ancestors)

Behavior

Intervention Hierarchy (Ancestors)

Exercise TherapyRehabilitationAftercareContinuity of Patient CarePatient CareTherapeuticsPhysical Therapy ModalitiesPhysical Conditioning, HumanExerciseMotor ActivityMovementMusculoskeletal Physiological PhenomenaMusculoskeletal and Neural Physiological Phenomena

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
INVESTIGATOR
Purpose
BASIC SCIENCE
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Ph D

Study Record Dates

First Submitted

April 28, 2015

First Posted

May 12, 2015

Study Start

January 1, 2013

Primary Completion

June 1, 2013

Study Completion

May 1, 2015

Last Updated

June 11, 2015

Record last verified: 2015-06