NCT01875146

Brief Summary

Investigation of the training effects following 8 weeks of high-intensity interval training (HIT)in combination with side-alternating whole-body vibration compared to conventional HIT or side-alternating whole-body vibration. The adaptations are investigated on a molecular (muscle biopsy of the M. vastus lateralis) and systemic (e.g. cycling, jumping mechanography, dynamometry) level. In addition, the acute effects of the first and last training session will be investigated on a molecular (e.g. satellite cell activation, mRNA abundance) and systemic (e.g. ventilatory ga exchange, heart rate, rating of perceived exertion) level.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
33

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Jan 2013

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2013

Completed
5 months until next milestone

First Submitted

Initial submission to the registry

May 16, 2013

Completed
26 days until next milestone

First Posted

Study publicly available on registry

June 11, 2013

Completed
6 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2013

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2013

Completed
Last Updated

January 7, 2014

Status Verified

December 1, 2013

Enrollment Period

11 months

First QC Date

May 16, 2013

Last Update Submit

January 6, 2014

Conditions

Health Behavior

Outcome Measures

Primary Outcomes (1)

  • Change from baseline in Critical Power

    The differences in changes in Critical Power \[Watts\] are compared between the 4 training groups. For this purpose, participants complete before and after the training intervention an incremental cycling ramp test and 4 cycling constant-load tests.

    8 weeks intervention

Study Arms (4)

4x4 min HIT

ACTIVE COMPARATOR

Conventional 4x4 min high-intensity interval training

Other: 4x4 min HIT

4x4 min HIT + WBV (18 Hz)

EXPERIMENTAL

4x4 min high-intensity interval training in combination with whole-body vibration at 18 Hz during the active rest

Other: 4x4 min HIT + WBV (18 Hz)

4x4 min HIT + WBV (30 Hz)

EXPERIMENTAL

4x4 min high-intensity interval training in combination with whole-body vibration at 30 Hz during the active rest

Other: 4x4 min HIT + (30 Hz)

whole-body vibration at 30 Hz

ACTIVE COMPARATOR

4x3 min whole-body vibration at 30 Hz

Other: whole-body vibration at 30 Hz

Interventions

4x4 min HITOTHER

Conventional 4x4 min high-intensity interval training

4x4 min HIT
4x4 min HIT + WBV (18 Hz)OTHER

4x4 min high-intensity interval training in combination with whole-body vibration at 18 Hz during the active rest

4x4 min HIT + WBV (18 Hz)
4x4 min HIT + (30 Hz)OTHER

4x4 min high-intensity interval training in combination with whole-body vibration at 30 Hz during the active rest

4x4 min HIT + WBV (30 Hz)
whole-body vibration at 30 HzOTHER

4x3 min whole-body vibration at 30 Hz

whole-body vibration at 30 Hz

Eligibility Criteria

Age18 Years - 35 Years
Sexmale
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • no fever / no common cold at the beginning of the study
  • between 18 and 35 years of age
  • non-smoker
  • no known cardiovascular or orthopedic problems
  • no cardiac pacemaker
  • fullfills healts questionnaire's requirements

You may not qualify if:

  • fever / common cold at beginning of study
  • age under 18 oder above 35y
  • smoker
  • cardiovascular or orthopedic problems
  • cardiac pacemaker
  • does not fullfill health questionnaire's requirements

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University Hospital Zurich, Division of Neurology

Zurich, Canton of Zurich, 8091, Switzerland

Location

Related Publications (1)

  • Mueller SM, Aguayo D, Zuercher M, Fleischmann O, Boutellier U, Auer M, Jung HH, Toigo M. High-intensity interval training with vibration as rest intervals attenuates fiber atrophy and prevents decreases in anaerobic performance. PLoS One. 2015 Feb 13;10(2):e0116764. doi: 10.1371/journal.pone.0116764. eCollection 2015.

    PMID: 25679998DERIVED

MeSH Terms

Conditions

Health Behavior

Condition Hierarchy (Ancestors)

Behavior

Study Officials

  • Hans H Jung, Prof MD

    University Hospital Zurich, Division of Neurology

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

May 16, 2013

First Posted

June 11, 2013

Study Start

January 1, 2013

Primary Completion

December 1, 2013

Study Completion

December 1, 2013

Last Updated

January 7, 2014

Record last verified: 2013-12

Locations

CH(1)