Coffee Roasting and Glucose Tolerance

NCT02417519 | Completed

• 1 other identifier: M217
• Study Type: interventional
• Target: 11
• Locations: 1 country
• Sites: 1

Brief Summary

Chlorogenic acid (CGA) in coffee may lower the postprandial glucose response. CGA is destroyed by dark roasting. In a controlled crossover trial, 11 healthy fasted volunteers consumed 300 mL of either light (LIR) or dark (DAR) roasted coffee, or water, followed 30 min later by a 75-g oral glucose tolerance test (OGTT). Plasma glukose and insulin, appetite, and plasma and urine metabolic profiles will be analysed. The primary aim is to investigate whether roasting affects the postprandial glucose area under the curve (AUC).

Conditions

Oral Glucose Tolerance

Keywords

Coffee; Chlorogenic acid; Insulin; Appetite; Metabolomics

Outcome Measures

Primary Outcomes (1)

• Plasma glucose Area Under the Curve (Glucose AUC)

  The area under the plasma glucose concentration curve was calculated from 0-120min after 75g glucose was ingested.

  0-120 min

Secondary Outcomes (6)

• Plasma glucose concentrations

  30, 60 and120 min

• Serum Insulin Area Under the Curve

  0-120 min

• Serum insulin concentrations

  30, 60 and120 min

• ISI(0-120)

  0-120min

• Metabolic profile in plasma

  0-24 hours

Study Arms (6)

Sequence A

EXPERIMENTAL

The meal study was performed with dark roast coffee (DAR), light roast coffe (LIR), or water (CTR) in a random sequence. Sequance A was DAR-LIR-CTR

Other: DAR; Other: LIR; Other: CTR

Sequence B

EXPERIMENTAL

The meal study was performed with dark roast coffee (DAR), light roast coffe (LIR), or water (CTR) in a random sequence. Sequance B was DAR-CTR-LIR

Other: DAR; Other: LIR; Other: CTR

Sequance C

EXPERIMENTAL

The meal study was performed with dark roast coffee (DAR), light roast coffe (LIR), or water (CTR) in a random sequence. Sequance C was LIR-DAR-CTR

Other: DAR; Other: LIR; Other: CTR

Sequence D

EXPERIMENTAL

The meal study was performed with dark roast coffee (DAR), light roast coffe (LIR), or water (CTR) in a random sequence. Sequance D was LIR-CTR-DAR

Other: DAR; Other: LIR; Other: CTR

Sequence E

EXPERIMENTAL

The meal study was performed with dark roast coffee (DAR), light roast coffe (LIR), or water (CTR) in a random sequence. Sequance E was CTR-DAR-LIR

Other: DAR; Other: LIR; Other: CTR

Sequence F

EXPERIMENTAL

The meal study was performed with dark roast coffee (DAR), light roast coffe (LIR), or water (CTR) in a random sequence. Sequance F was CTR-LIR-DAR

Other: DAR; Other: LIR; Other: CTR

Interventions

DAR OTHER

Volunteers ingested 300 mL of coffee with a dark roast containing low levels of chlorogenic acids followed 30 min later by by 75g glucose and 300 mL water

Also known as: 300 mL of coffee with a dark roast + OGTT

Sequance C; Sequence A; Sequence B; Sequence D; Sequence E; Sequence F

LIR OTHER

Volunteers ingested 300 mL of coffee with a light roast containing high levels of chlorogenic acids followed 30 min later by by 75g glucose and 300 mL water

Also known as: 300 mL of coffee with a light roast + OGTT

Sequance C; Sequence A; Sequence B; Sequence D; Sequence E; Sequence F

CTR OTHER

Volunteers ingested 300 mL of water containing no chlorogenic acids followed 30 min later by by 75g glucose and 300 mL water

Also known as: 300 mL of water + OGTT

Sequance C; Sequence A; Sequence B; Sequence D; Sequence E; Sequence F

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Body mass index (BMI) of 18.0-30.0 kg/m2 and with no known diseases

You may not qualify if:

• systemic infections,
• psychiatric or metabolic disorders,
• known food allergies or intolerances related to the products used in the study (e.g. dairy or gluten),
• ongoing or former drug abuse,
• high intake of alcohol (defined as a weekly intake of \>7 units for women and \> 14 units for men),
• pregnancy or ongoing planning of pregnancy,
• vegetarianism or veganism,
• participation in other scientific studies during the study period, and
• blood donation during - or in the month leading up to - the study period

Sponsors & Collaborators

• University of Copenhagen: lead

Study Sites (1)

Department of Nutrition, Exercise and Sports, University of Copenhagen

Frederiksberg, 1958, Denmark

Location

MeSH Terms

Conditions

Insulin Resistance

Interventions

Coffee; Glucose Tolerance Test; Water

Condition Hierarchy (Ancestors)

Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases

Intervention Hierarchy (Ancestors)

Plant Preparations; Biological Products; Complex Mixtures; Beverages; Diet, Food, and Nutrition; Physiological Phenomena; Food and Beverages; Blood Chemical Analysis; Clinical Chemistry Tests; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Diagnostic Techniques, Endocrine; Investigative Techniques; Hydroxides; Alkalies; Inorganic Chemicals; Anions; Ions; Electrolytes; Oxides; Oxygen Compounds

Study Officials

• Lars O Dragsted, PhD

  University of Copenhagen

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: PREVENTION
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: April 11, 2015
• First Posted: April 15, 2015
• Study Start: April 1, 2014
• Primary Completion: September 1, 2014
• Study Completion: November 1, 2015
• Last Updated: December 12, 2017

Record last verified: 2017-12

Locations

DK (1)