Post-exercise Hypotension After a Power Training Session in Older Adults With Hypertension

NCT03615625 | Completed

• 1 other identifier: 85210618.1.0000.5327
• Study Type: interventional
• Target: 24
• Locations: 1 country
• Sites: 1

Brief Summary

The main purpose of the present study was to evaluate the effect of a power training session on office and 24h ambulatory blood pressure in older adults with hypertension. As secondary outcomes, the investigators compared post-exercise hypotension, BP variability, and endothelial function between older men and women with hypertension. The working hypothesis was that a single bout of power exercise would decrease both office and 24 h BP in comparison to a non-exercising control session and men and women would respond differently after a power training session.

Conditions

Hypertension

Keywords

Exercise; Aging; Ambulatory Blood Pressure Monitoring; Power Exercise

Outcome Measures

Primary Outcomes (1)

• Ambulatory Blood Pressure Monitoring

  Mean 24-h, day-time, night-time of blood pressure in mmHg will be assessed after each experimental session (power training session and control session)

  24 hours after control and power training exercise session

Secondary Outcomes (4)

• Office Systolic Blood Pressure

  60 minutes after control and power training exercise session

• Office Diastolic Blood Pressure

  60 minutes after control and power training exercise session

• Endothelial Function

  60 minutes after control and power training exercise session

• Blood Pressure Variability

  24 hours after control and power training exercise session

Other Outcomes (1)

• Sex Differences in Ambulatory Blood Pressure Monitoring, Office Blood Pressure, Endothelial Function and Blood Pressure Variability

  60 minutes and 24 hours after control and power training exercise session

Study Arms (2)

Control session

NO INTERVENTION

Control session without any exercise. The participants remained in seated rest throughout 40 min

Power Training Session

EXPERIMENTAL

The power training session lasted 40 min, in which the participants performed a resistance exercise session using high velocity contractions during the exercises characterizing a power training session

Behavioral: Power Training Session

Interventions

Power Training Session BEHAVIORAL

3 sets of 8-10 repetitions of 5 exercises performed in the following order: leg press, bench press, knee extension, upright row, and knee flexion, using an intensity corresponding to 50 % of 1-RM and two-minute intervals between sets and exercises. The concentric phase of exercises during each repetition was performed "as fast as possible" while the eccentric phase lasted 1-2 seconds.

Power Training Session

Eligibility Criteria

• Age: 60 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Office blood pressure between 130-179 and 80-110 mmHg for systolic and diastolic blood pressure, respectively;
• Non-engaged in structured programs of exercise for the last 3 months since the beginning of this study;
• Able to perform the proposed exercises.

You may not qualify if:

• Underlying cardiovascular disease previously diagnosticated by a doctor, occurred in the last 24 months, such as: acute myocardial infarction, angina, stroke or heart failure;
• Diseases that reduce life expectancy;
• Smokers and ex-smokers for less than six months;
• BMI \> 39.9 kg/m²
• diabetic proliferative retinopathy.

Sponsors & Collaborators

• Hospital de Clinicas de Porto Alegre: lead
• Federal University of Rio Grande do Sul: collaborator

Study Sites (1)

Hospital de Clinicas de Porto Alegre

Porto Alegre, Rio Grande do Sul, 90035-903, Brazil

Location

Related Publications (1)

• de Oliveira Carpes L, Domingues LB, Schimitt R, Fuchs SC, Alhalimi T, Tanaka H, Ferrari R. Sex Differences in Post-exercise Hypotension, Ambulatory Blood Pressure Variability, and Endothelial Function After a Power Training Session in Older Adults. Front Physiol. 2021 Jul 16;12:657373. doi: 10.3389/fphys.2021.657373. eCollection 2021.

  PMID: 34335289 DERIVED

MeSH Terms

Conditions

Hypertension; Motor Activity

Condition Hierarchy (Ancestors)

Vascular Diseases; Cardiovascular Diseases; Behavior

Study Officials

• Rodrigo Ferrari, PhD

  Federal University of Rio Grande do Sul

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Masking Details: The randomization list was generated by an epidemiologist using a computer software. This epidemiologist did not participate in the recruitment or assignment to the experimental sessions. Participants and the research team were blinded to the randomization list until the moment of assignment.
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: A randomized controlled clinical trial with crossover design was performed in order to evaluate the effect of a power training session on office and 24h ambulatory blood pressure in older adults with hypertension.

Study Record Dates

• First Submitted: July 31, 2018
• First Posted: August 6, 2018
• Study Start: June 12, 2018
• Primary Completion: July 20, 2019
• Study Completion: January 1, 2020
• Last Updated: January 14, 2021

Record last verified: 2021-01

Locations

BR (1)