The China-Anhui Birth Cohort Study (C-ABCS)

NCT02391610 | Completed DMC

• 1 other identifier: 2008020
• Study Type: observational
• Target: 16,766
• Locations: 0 countries
• Sites: N/A

Brief Summary

The China-Anhui Birth Cohort Study (C-ABCS) was set up to examine the delayed, cumulative and interactive effects of maternal environmental exposures on birth outcomes and children's development. The C-ABCS recruited pregnant women from six major cities of Anhui province, China, between November 2008 and October 2010. A range of data (including demographic, obstetric, occupational, nutritional and psychosocial factors) were collected by both interviews and laboratory tests. In each trimester, women's blood samples were drawn, and pregnancy complications were abstracted from physician's medical records. By the end of 2011, birth outcomes/birth defects were observed/identified by clinicians within 12 months after the delivery of 11 421 singleton live births of six cities and those outcomes among the remaining 2033 live births are still being observed. In addition, 4668 children from Ma'anshan city will be further followed up during the pre-school period till they reach adolescence to obtain the data on familial environmental exposures as well as children's physical, psychological, behavioural and sexual development. The interview data and information on laboratory examinations are available on request from archives in the Anhui Provincial Key Laboratory of Population Health \& Aristogenics.

Conditions

Environmental Exposures; Other Pregnancy With Abortive Outcome; Birth Defects; Children Development

Keywords

birth cohort study; environmental exposures; birth defects; pregnant outcomes; children development

Outcome Measures

Primary Outcomes (1)

• Pregnancy outcomes and birth defects

  By clinical diagnosis, including abortion/premature birth/prolonged pregnancy/fetal death/stillbirth/live birth, Low birthweight/macrosomia/small for gestation age/large for gestation age, Structural birth defects and functional birth defects

  Up to 12 months of age

Secondary Outcomes (5)

• Children's physical development

  At ages of 1.5-3 and 4.5-6 years

• Psychological and behavioural development

  At ages of 1.5-3 and 4.5-6 years

• Family environmental exposure

  At ages of 1.5-3 and 4.5-6 years

• Mental health problems

  At ages of 1.5-3 & 4.5-6 years

• Sexual development indicators

  At ages of 9-15 years for boys, and 8-14 years for girls

Interventions

No intervention OTHER

Eligibility Criteria

• Age: 17 Years - 49 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

The China-Anhui Birth Cohort Study (C-ABCS) is a prospective population-based cohort study that recruited 16766 pregnant women from six major cities of Anhui province in China between November 2008 and October 2010. Six cities were selected for study sites, including Hefei, Ma'anshan, Wuhu, Jieshou, Lu'an and Ningguo. Anhui province is located in the south-east of China. Its socio-economic development is ranked at the mid-level in China. Six cities were selected according to their social and geographic characteristics. These cities are located in Central, Southern and Northern regions of Anhui Province and may represent socio-economic, geographic and cultural variations. In addition, strong local support was one of the important factors to consider in selecting these cities.

You may qualify if:

• Having been lived in local city at least 6 months;
• Establishing maternal card in the hospital for the first time;
• Gestational week ≤ 16 weeks;
• Willing to have antenatal checkups and childbirth in the hospital where they establish maternal cards.

You may not qualify if:

• Women who have abnormities in speaking and can not complete the survey by themselves;
• Women with mental disorders;
• Women who plan to leave local places.

Sponsors & Collaborators

• Fangbiao Tao: lead

Related Publications (1)

• Tao FB, Hao JH, Huang K, Su PY, Cheng DJ, Xing XY, Huang ZH, Zhang JL, Tong SL. Cohort Profile: the China-Anhui Birth Cohort Study. Int J Epidemiol. 2013 Jun;42(3):709-21. doi: 10.1093/ije/dys085. Epub 2012 Jun 21.

  PMID: 22729236 RESULT

MeSH Terms

Conditions

Congenital Abnormalities

Condition Hierarchy (Ancestors)

Congenital, Hereditary, and Neonatal Diseases and Abnormalities

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Professor and Dean

Study Record Dates

• First Submitted: March 12, 2015
• First Posted: March 18, 2015
• Study Start: November 1, 2008
• Primary Completion: October 1, 2010
• Study Completion: January 1, 2015
• Last Updated: March 18, 2015

Record last verified: 2015-03