Characteristics of Infective Endocarditis in East China

NCT04977518 | Completed

• 1 other identifier: 2015-046
• Study Type: observational
• Target: 183
• Locations: 0 countries
• Sites: N/A

Brief Summary

This was a retrospective observational study of consecutive cases of definite or possible infective endocarditis (IE) as per the modified Duke criteria between January 2008 and December 2015, which was performed at the Second Affiliated Hospital of Zhejiang University, School of medicine (SAHZU), a tertiary care referral hospital located in East China.

Conditions

Infective Endocarditis

Outcome Measures

Primary Outcomes (2)

• Complications (neurological events, systemic embolism, and congestive heart failure) of infective endocarditis

  1. A neurological event was defined as symptomatic or asymptomatic stroke, hemorrhage, or encephalopathy. 2. Systemic embolization was defined as an embolic event outside of the central nervous system. 3. Congestive heart failure was defined as with class III, or IV heart failure and an ejection fraction of 40% or less.

  During the hospitalization, average of 1 months

• Mortality

  Patients dead or moribund before discharge

  During the hospitalization, average of 1 months

Study Arms (2)

Patients diagnosed during 2008-2011

Patients diagnosed with definite and probable infective endocarditis defined according to the modified Duke clinical criteria during 2008-2011

Other: no intervention

Patients diagnosed during 2012-2015

Patients diagnosed with definite and probable infective endocarditis defined according to the modified Duke clinical criteria during 2012-2015

Other: no intervention

Interventions

no intervention OTHER

no intervention

Patients diagnosed during 2008-2011; Patients diagnosed during 2012-2015

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with a clinical diagnosis of infective endocarditis between January 2008 and December 2015 in a tertiary hospital located in the East China

You may qualify if:

• Patients with a clinical diagnosis of infective endocarditis.

You may not qualify if:

• Patients did not meet the modified Duke criteria.

Sponsors & Collaborators

• Second Affiliated Hospital, School of Medicine, Zhejiang University: lead

MeSH Terms

Conditions

Endocarditis

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases

Study Officials

• Huimin Xu

  2nd Affiliated Hospital, School of Medicine, Zhejiang University, China

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 13, 2021
• First Posted: July 27, 2021
• Study Start: January 1, 2008
• Primary Completion: December 31, 2015
• Study Completion: October 20, 2016
• Last Updated: July 27, 2021

Record last verified: 2016-03

Data Sharing

• IPD Sharing: Will not share