Effects of Low Calorie Sweeteners on Dietary Intakes, Hunger, Appetite and Satiety

NCT02297880 | Completed

• 1 other identifier: CreaBIO1
• Study Type: interventional
• Target: 170
• Locations: 1 country
• Sites: 1

Brief Summary

Although there is evidence that low calorie sweeteners (LCS) do not stimulate hunger or appetite, divergent opinions appear regularly both in the scientific literature and in the popular press. The goal of this study is to examine the effects of LCS containing beverages on appetite and intake in healthy individuals.

Conditions

Eating Behavior

Keywords

low calorie sweetener satiety, intake, hunger

Outcome Measures

Primary Outcomes (1)

• Subjective sensations: hunger, satiety and desire to eat

  Visual Analog Scales

  9 weeks

Secondary Outcomes (2)

• Energy and macronutrient intakes

  9 weeks

• Anthropometric parameters

  9 weeks

Study Arms (2)

Beverage containing low calorie sweeteners

EXPERIMENTAL

Beverage containing low calorie sweeteners (flavour)

Other: Beverage containing low calorie sweeteners

Still water

ACTIVE COMPARATOR

Still water (no flavour)

Other: Still water

Interventions

Beverage containing low calorie sweeteners OTHER

Beverage containing low calorie sweeteners

Beverage containing low calorie sweeteners

Still water OTHER

Still water (no flavour)

Still water

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Body Mass Index: Lower limit 18 kg/m²; Upper limit 28 kg/m²; weight stable within ± 3 kg in the last 6 months
• Habitual energy intake within the 95% confident interval of the reference energy intake for the French population (as provided by the INCA 2 survey
• Must not be a regular drinker of LCS beverages (less than once a week no more than every 15 days) and be willing to use LCS according to protocol
• For female participants: not pregnant, not breast feeding, planning to become pregnant during the study or on contraception since at least 3 months (regular 28-day cycle)
• Subject registered with the French Social Security.

You may not qualify if:

• Currently diagnosed somatic pathology
• On medication affecting metabolism, weight, energy intake, or energy expenditure in the last 6 months
• Major psychiatric disorder, particularly eating disorders as defined by the Diagnostic and Statistical Manual od Mental Disorders-IV
• Rejection of sweet foods or drinks as revealed by the diet history
• Smoking subject planning to stop smoking in the next 3 months
• Subjects suffering from food allergies or intolerance
• Subject not capable of understanding the constraints of the study and who not agree to abide

Sponsors & Collaborators

• The Coca-Cola Company: lead
• CreaBIO: collaborator

Study Sites (1)

CreaBio Rhône-Alpes laboratory, 9 avenue du Professeur Fleming

Givors, Lyon, 69700, France

Location

Related Publications (1)

• Fantino M, Fantino A, Matray M, Mistretta F. Beverages containing low energy sweeteners do not differ from water in their effects on appetite, energy intake and food choices in healthy, non-obese French adults. Appetite. 2018 Jun 1;125:557-565. doi: 10.1016/j.appet.2018.03.007. Epub 2018 Mar 9.

  PMID: 29526693 DERIVED

MeSH Terms

Conditions

Feeding Behavior

Condition Hierarchy (Ancestors)

Behavior, Animal; Behavior

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 13, 2014
• First Posted: November 21, 2014
• Study Start: October 1, 2014
• Primary Completion: March 1, 2016
• Study Completion: March 1, 2016
• Last Updated: February 9, 2017

Record last verified: 2017-02

Locations

FR (1)