The Effect of Food Hedonics on Appetite Hormones Levels

NCT02615613 | Completed DMC

• 1 other identifier: NUT.AO.11
• Study Type: interventional
• Target: 11
• Locations: 0 countries
• Sites: N/A

Brief Summary

30-40 healthy male subjects with a BMI between 18.5 and 24.9 kg/m2 will be tested for food preferences using a questionnaire with 141 different foods. Accordingly, a high acceptability/palatability food will be selected (average score of ≥ 7 on the 9-point hedonic scale). Two versions of the selected high palatability food will be devised by modifying it to yield the original high and the modified low acceptability versions. The two versions will differ only in palatability and will be equicaloric. Subjects who agree on the acceptability of the two versions of the food (11 subjects) will consume, at fasting, the two versions of the food in a cross over design over two sessions. Each session will include an acceptability test, using the 9-point hedonic scale, on three instances: after sampling a spoonful, eating the whole portion and after 240 min. The quantity consumed on each session will constitute 30% of the subject's resting energy expenditure. Moreover, fasting and postprandial hunger ratings and blood samples will be collected at time 0 and after 15, 30, 60, 120, 180 and 240 min of the food/meal's ingestion. The visual analogue scale will be used for huger ratings.

Conditions

Eating Behavior

Keywords

Hedonics, Ghrelin, Hunger

Outcome Measures

Primary Outcomes (2)

• Food acceptability score

  Two weeks

• Ghrelin level

  Two weeks

Secondary Outcomes (3)

• Glucose level

  Two weeks

• Appetite score on the visual analogue scale

  Two weeks

• Insulin level

  2 weeks

Study Arms (2)

High acceptability meal

EXPERIMENTAL

A custard recipe was used as the high acceptability meal

Other: High acceptability meal

Low acceptability meal

EXPERIMENTAL

The regular custard recipe was reformulated to yield a low acceptability version

Other: Low Acceptability Meal

Interventions

Low Acceptability Meal OTHER

Low acceptability meal

High acceptability meal OTHER

High acceptability meal

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Gender: Male
• Age: 18-50 years
• Body Mass Index (BMI): 18.5-24.9 kg/m2
• Stable body weight for at least three months before the study with absence of any form of dieting, food restriction or other abnormal eating behaviors (to minimize effect of weight change on ghrelin status)

You may not qualify if:

• Smoking
• Substance abuse such as alcohol or drugs
• Medical or psychological illness
• Use of medications
• Previous gastrointestinal surgery
• History of weight fluctuation (weight loss of greater than 5% within the past 3 months)

Sponsors & Collaborators

• American University of Beirut Medical Center: lead

MeSH Terms

Conditions

Feeding Behavior

Condition Hierarchy (Ancestors)

Behavior, Animal; Behavior

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: November 25, 2015
• First Posted: November 26, 2015
• Study Start: January 1, 2014
• Primary Completion: June 1, 2015
• Study Completion: June 1, 2015
• Last Updated: November 30, 2015

Record last verified: 2015-11