GWAS in a Small Group of Metabolically Healthy Obese White Adults

NCT02105909 | Completed

• 1 other identifier: NIH P20 RR-016464
• Study Type: interventional
• Target: 81
• Locations: 0 countries
• Sites: N/A

Brief Summary

This is a GWAS pilot study that aims to identified possible candidate genes associate to obesity by exploring single nucleotide polymorphism (SNP) in a small group of obese , metabolically healthy white adults, matched with lean, white adults , metabolically healthy. The investigators hypothesize that the careful phenotyping of the subject sand matching with increase the power to find SNP significantly associate with obesity (as defined by BMI).

Conditions

Obesity

Outcome Measures

Primary Outcomes (1)

• number of SNPs associated with high BMI

  Using GWAS to identify candidate genes associate with obesity (high BMI) in a carefully phenotyped white adults with obesity (as defined by BMI), metabolically healthy, matched with lean, white adults metabolically healthy.

  baseline

Study Arms (2)

obese subjects

EXPERIMENTAL

DNA analysis

Other: GWAS

lean subjects

PLACEBO COMPARATOR

DNA analysis

Other: GWAS

Interventions

GWAS OTHER

lean subjects; obese subjects

Eligibility Criteria

• Age: 40 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• \- Adults 40 year old or older
• Caucasian males or females
• BMI ≥ 35 kg/m² or history of BMI ≥ 35 kg/m², or BMi less than 25 kg/m2
• No current or past use of glucose lowering drugs
• No current or past medical history of diabetes mellitus
• No current or past medical history of established coronary artery disease (angina, myocardial infraction, abnormal cardiac stress test)
• No current or past medical history of or treatment for thyroid disorders
• No current or past use of lipid lowering drugs or diagnosis of a lipid disorder
• No current or past medical history of or treatment for hypertension
• Subject's willingness to provide the study investigators with a copy of their medical records or give permission to the study investigators to access the following specific medical information:
• Fasting plasma glucose (less than 100 mg/dL/5.6 mmol/L)
• HDL-C cholesterol (more than 40 mg/dL /1.03 mmol/L)
• Total cholesterol (less than 239 mg/dL/ 6.18mmol/L)
• LDL cholesterol (less than 159 mg/dL/4.11 mmol/L)

You may not qualify if:

• \- Known monogenic forms of obesity
• Polycystic ovary disease (in women)
• Malabsorptive or maldigestive syndromes (Celiac disease, Crohn's Disease, inflammatory bowel disease, etc.)
• Anorexia nervosa or bulimia

Sponsors & Collaborators

• University of Nevada, Las Vegas: lead

MeSH Terms

Conditions

Obesity

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor of Medicine

Study Record Dates

• First Submitted: March 26, 2014
• First Posted: April 7, 2014
• Study Start: May 1, 2009
• Primary Completion: November 1, 2013
• Study Completion: November 1, 2013
• Last Updated: April 7, 2014

Record last verified: 2014-04