Disturbed Structural Connectivity of Frontostriatal and Frontoparietal Networks in Adults With ADHD

NCT02232464 | Completed DMC

• 1 other identifier: 201312144RINB
• Study Type: observational
• Target: 90
• Locations: 1 country
• Sites: 1

Brief Summary

Attention deficit/hyperactivity disorder (ADHD) is a common, impairing, childhood onset neuropsychiatric disorder with executive dysfunctions. The ADHD symptoms and executive deficits may last to adulthood. Our previous studies, like western results, have shown that children with ADHD have disrupted microstructural integrity of frontostriatal fiber pathways and impaired brain activity in frontoparietal network. However, there is lack of data with regards to whether adults with ADHD also demonstrate structural and functional disconnectivity of frontostriatal and frontoparietal networks as compared to healthy controls without ADHD in Asian population and no study has been done to correlate a wide range of executive functions with the connectivity of these two networks. Specific Aims:

1. 1.to compare the executive functions, and structural and functional connectivity in frontostriatal and frontoparietal circuitries between adults with ADHD and healthy controls without ADHD;
2. 2.to correlate the data from structural and functional connectivity, executive functions, and ADHD core symptoms stratifying by the ADHD and controls; and
3. 3.to explore other circuitries that may involve in ADHD by using whole brain tractography analyses.

Conditions

Attention Deficit Hyperactivity Disorder

Keywords

Adult ADHD; diffusion spectrum imaging; resting-state fMRI; frontostriatal circuitries; frontoparietal circuitries; executive function

Outcome Measures

Primary Outcomes (1)

• Structural neuroimaging

  Using diffusing spectrum imaging (DSI) to assess the structural connectivity in frontostriatal, frontoparietal and other circuitries.

  one day

Secondary Outcomes (1)

• Functional connectivity of the brain circuits

  one day

Study Arms (2)

ADHD group

Adults with clinical diagnosis of ADHD according to the DSM-IV criteria

Control group

Age-, sex-, and IQ-matched healthy controls without lifetime diagnosis with ADHD

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

The sample consists of 50 adults (ages 18-45) with clinical diagnosis of ADHD according to the DSM-IV criteria and 50 age-, sex-, and IQ-matched healthy controls without lifetime diagnosis with ADHD.

You may qualify if:

• Subjects aged 18-45, who have clinical diagnosis of a ADHD according to the DSM-IV criteria.

You may not qualify if:

• The subjects will be excluded from the study if they meet any of the following criteria: (1) Comorbidity with diagnoses of autism spectrum disorder, schizophrenia, schizoaffective disorder, delusional disorder, other psychotic disorder, organic psychosis, schizotypal personality disorder, bipolar disorder, depression, severe anxiety disorders or substance use; (2) With neurodegenerative disorder, epilepsy, involuntary movement disorder, congenital metabolic disorder, brain tumor, history of severe head trauma, and history of craniotomy; (3)With visual or hearing impairments, or motor disability which may influence the process of MRI assessment; and (4) Full-scale IQ lower than 80.

Sponsors & Collaborators

• National Taiwan University Hospital: lead

Study Sites (1)

National Taiwan Univeristy Hospital

Taipei, Taiwan

Location

MeSH Terms

Conditions

Attention Deficit Disorder with Hyperactivity

Condition Hierarchy (Ancestors)

Attention Deficit and Disruptive Behavior Disorders; Neurodevelopmental Disorders; Mental Disorders

Study Officials

• Susan Shur-Fen Gau, MD, PhD

  National Taiwan University Hospital & College of Medicine

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 27, 2014
• First Posted: September 5, 2014
• Study Start: January 1, 2014
• Primary Completion: December 1, 2014
• Study Completion: December 1, 2014
• Last Updated: March 18, 2015

Record last verified: 2015-03

Locations

TW (1)