NCT02232464

Completed

Disturbed Structural Connectivity of Frontostriatal and Fron...

National Taiwan University Hospital Source

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Other study identifiers

Sponsor study identifier

201312144RINB

Study Type

observational

Actual enrollment (reported)

90

Locations

1 country

Sites

1

Timeline

Study Start

January 2014

Date type not reported

This date has not been verified as actual or estimated.

Primary Completion

December 2014

Actual (reported)

Study Completion

December 2014

Actual (reported)

Brief Summary

Attention deficit/hyperactivity disorder (ADHD) is a common, impairing, childhood onset neuropsychiatric disorder with executive dysfunctions. The ADHD symptoms and executive deficits may last to adulthood. Our previous studies, like western results, have shown that children with ADHD have disrupted microstructural integrity of frontostriatal fiber pathways and impaired brain activity in frontoparietal network. However, there is lack of data with regards to whether adults with ADHD also demonstrate structural and functional disconnectivity of frontostriatal and frontoparietal networks as compared to healthy controls without ADHD in Asian population and no study has been done to correlate a wide range of executive functions with the connectivity of these two networks. Specific Aims:

1.to compare the executive functions, and structural and functional connectivity in frontostriatal and frontoparietal circuitries between adults with ADHD and healthy controls without ADHD;
2.to correlate the data from structural and functional connectivity, executive functions, and ADHD core symptoms stratifying by the ADHD and controls; and
3.to explore other circuitries that may involve in ADHD by using whole brain tractography analyses.

Registry Overview

Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.

Recruitment status: completed
Actual enrollment (reported): 90 participants
Study completion date: December 2014
Actual (reported)
Listed locations: 1 countries · 1 sites

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.

Study Start
January 2014
Date type not reported
This date has not been verified as actual or estimated.
First Submitted
August 27, 2014
Actual (reported)
First Posted
September 5, 2014
Actual (reported)
Primary Completion
December 2014
Actual (reported)
Study Completion
December 2014
Actual (reported)

Last Updated: March 18, 2015
Status Verified: March 2015
Last Update Submitted: March 16, 2015

Conditions

Attention Deficit Hyperactivity Disorder

Keywords

Adult ADHDdiffusion spectrum imagingresting-state fMRIfrontostriatal circuitriesfrontoparietal circuitriesexecutive function

Outcome Measures

Primary Outcomes (1)

Structural neuroimaging
Using diffusing spectrum imaging (DSI) to assess the structural connectivity in frontostriatal, frontoparietal and other circuitries.
one day

Secondary Outcomes (1)

Functional connectivity of the brain circuits
one day

Study Arms (2)

ADHD group

Adults with clinical diagnosis of ADHD according to the DSM-IV criteria

Control group

Age-, sex-, and IQ-matched healthy controls without lifetime diagnosis with ADHD

Eligibility Criteria

Age18 Years - 45 Years

Sexall

Healthy VolunteersYes

Age GroupsAdult (18-64)

Sampling MethodNon-Probability Sample

Study Population

The sample consists of 50 adults (ages 18-45) with clinical diagnosis of ADHD according to the DSM-IV criteria and 50 age-, sex-, and IQ-matched healthy controls without lifetime diagnosis with ADHD.

You may qualify if:

Subjects aged 18-45, who have clinical diagnosis of a ADHD according to the DSM-IV criteria.

Sponsors & Collaborators

National Taiwan University Hospital
Otherlead

Study Sites (1)

National Taiwan Univeristy Hospital

Taipei, Taiwan

MeSH Terms

Conditions

Attention Deficit Disorder with Hyperactivity

Condition Hierarchy (Ancestors)

Attention Deficit and Disruptive Behavior DisordersNeurodevelopmental DisordersMental Disorders

Study Officials

Susan Shur-Fen Gau, MD, PhD
National Taiwan University Hospital & College of Medicine
PRINCIPAL INVESTIGATOR

Enrollment

90 participants (actual enrollment reported by the registry).

Study Design

Study Type: observational
Observational Model: CASE CONTROL
Time Perspective: CROSS SECTIONAL
Sponsor Type: OTHER
Responsible Party: SPONSOR

Study Record Dates

First Submitted

August 27, 2014

First Posted

September 5, 2014

Study Start

January 2014

Date type not reported

This date has not been verified as actual or estimated.

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You may not qualify if:

The subjects will be excluded from the study if they meet any of the following criteria: (1) Comorbidity with diagnoses of autism spectrum disorder, schizophrenia, schizoaffective disorder, delusional disorder, other psychotic disorder, organic psychosis, schizotypal personality disorder, bipolar disorder, depression, severe anxiety disorders or substance use; (2) With neurodegenerative disorder, epilepsy, involuntary movement disorder, congenital metabolic disorder, brain tumor, history of severe head trauma, and history of craniotomy; (3)With visual or hearing impairments, or motor disability which may influence the process of MRI assessment; and (4) Full-scale IQ lower than 80.

Contact the study team to confirm eligibility.

Primary Completion

December 2014

Actual (reported)

Study Completion

December 2014

Actual (reported)

Last Updated

March 18, 2015

Record last verified: 2015-03

Source record

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Source: ClinicalTrials.gov.

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Registry identifier: NCT02232464
Data provider: ClinicalTrials.gov
Source updated: 2015-03-18
Normalization version: ctgov-legacy-1

Open registry record

Source retrieved: 2026-10-25 22:25:30 UTC

Locations

TW(1)

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

Study Start

First Submitted

First Posted

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (1)

Study Arms (2)

ADHD group

Control group

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Source record

Locations