NCT01052753|CompletedDMC
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Sponsor study identifier
observational
300
1 country
1
Study Start
August 1, 2010
Actual (reported)Primary Completion
July 31, 2013
Actual (reported)Study Completion
July 31, 2013
Actual (reported)The ultimate goal of this study is to find specific polymorphism of candidate genes (particularly of dopaminergic and noradrenergic systems) associated with intermediate phenotypes (e.g., executive functions, IQ, and other neuropsychological function) and/or phenomenological phenotypes (subtypes, comorbidity, dimensional approach) of ADHD. We propose to replicate the analysis of the candidate genes identified by previous genetic studies and recent findings from GWAS on ADHD using the candidate gene association study design (family-based case control study using parental controls and population-based case-control study). These results may lead our research team: (1) to resolve controversies over inconsistent findings in previous genetic studies and contribute to the literature on the validity of ADHD and its subtypes using clinical and genetic data; (2) to identify potential endophenotypes for ADHD genetic studies; and (3) to identify specific polymorphism of candidate genes and gene expressions of dopaminergic and noradrenergic systems associated with executive functions measured by the CANTAB.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
July 31, 2013
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
January 18, 2010
Actual (reported)January 20, 2010
Actual (reported)August 1, 2010
Actual (reported)July 31, 2013
Actual (reported)July 31, 2013
Actual (reported)The proband sample will consist of at least 150 drug-naïve children and adolescents with ADHD, aged 7-18 (who are able to perform the CANTAB and time tasks) from Department of Psychiatry, National Taiwan University Hospital (NTUH). Their biological parents (n = 300) and siblings (estimated number = 150) born to the same biological parents will be recruited as the parent controls and sibling controls, respectively, for the family-based case control study. We will recruit 150 school controls without lifetime diagnosis of ADHD in the same school districts and with similar age and gender distributions of the probands with ADHD.
National Taiwan Univeristy Hospital
Taipei, Taiwan
The subjects will receive blood withdrawal. The blood sample will be used for establishing lymphoblastoid cell lines, which will be used for molecular genetic experiments.
Susan Shur-Fen Gau, MD, PhD
National Taiwan University Hospital & College of Medicine
300 participants (actual enrollment reported by the registry).
First Submitted
January 18, 2010
First Posted
January 20, 2010
Study Start
August 1, 2010
Actual (reported)Adult Outcome of Children With Attention-deficit/Hyperactivity Disorder
Contact the study team to confirm eligibility.
Primary Completion
July 31, 2013
Actual (reported)Study Completion
July 31, 2013
Actual (reported)Last Updated
September 5, 2021
Record last verified: 2021-09
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Source: ClinicalTrials.gov.
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