A Follow-up, Family Study on Attention-deficit Hyperactivity Disorder

NCT00417781 | Completed DMC

• 6 other identifiers: 9361700470NHRI-EX94-9407PCNHRI-EX95-9407PCNHRI-EX96-9607PCNHRI-EX97-9707PCNHRI-EX98-9507PC
• Study Type: observational
• Target: 1,800
• Locations: 1 country
• Sites: 1

Brief Summary

Background: Attention deficit hyperactivity disorder (ADHD), characterized by inattention, hyperactivity and impulsivity, is an early onset, common (5-10% worldwide; 7.5% in Taiwan), clinically heterogeneous, impairing disorder. Despite the abundance of research on ADHD, the vast majority of samples have been limited to Caucasians; there is limited information about the expressions, patterns, correlates, and outcomes for ADHD in the Taiwanese population. Specific Aims:

1. 1.to investigate the neuropsychological functioning, and psychiatric, academic, and social outcomes of ADHD at adolescence;
2. 2.to examine the psychopathology and neuropsychological functioning among parents and siblings of ADHD probands;
3. 3.to determine the components of ADHD and neuropsychological functioning with the greatest familial recurrence risks; and
4. 4.to validate the classification of ADHD and comorbid subtypes of ADHD using psychosocial, familial, neuropsychological and longitudinal data.

Conditions

Attention Deficit Hyperactivity Disorder

Keywords

ADHD, adolescence, family study, endophenotype, outcome

Eligibility Criteria

• Age: 10 Years - 18 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Community-based sample \& children with ADHD and their families

You may qualify if:

• Community-based sample for the development of several Chinese versions of instruments: SNAP-IV, SDQ, ASRI, and ASRS.
• ADHD follow-up family studies (ADHD group): (1) that subjects either had the clinical diagnosis of DSM-IV ADHD, which was made by a full-time child psychiatrist at the first visit and following visits or by a child psychiatrist using the K-SADS-E as the second-stage case ascertainment at an epidemiological study; (2) the diagnoses of ADHD were made 3-6 years ago; (3) their ages range from 12 to 15 when we conduct study; (4) subjects have at least one sibling aged 6-18 and live with at least one biological parent; and (5) subjects and their family consent to participate in this study.
• (control group)(1) that subjects were assessed either at a clinical setting or in an epidemiological study same as to those in the exposed group 6 years ago; (2) their ages range from 12 to 15 when we conduct study; (3) subjects have at least one sibling aged 6-18 and live with at least one biological parent; and (4) subjects and their family consent to participate in this study.

Sponsors & Collaborators

• National Taiwan University Hospital: lead
• National Health Research Institutes, Taiwan: collaborator

Study Sites (1)

National Taiwan Univeristy Hospital

Taipei, 10002, Taiwan

Location

Related Publications (4)

• Chiang HL, Gau SS. Impact of executive functions on school and peer functions in youths with ADHD. Res Dev Disabil. 2014 May;35(5):963-72. doi: 10.1016/j.ridd.2014.02.010. Epub 2014 Mar 11.

  PMID: 24636025 DERIVED

• Gau SS, Chiang HL. Association between early attention-deficit/hyperactivity symptoms and current verbal and visuo-spatial short-term memory. Res Dev Disabil. 2013 Jan;34(1):710-20. doi: 10.1016/j.ridd.2012.10.005. Epub 2012 Nov 5.

  PMID: 23137723 DERIVED

• Wu SY, Gau SS. Correlates for academic performance and school functioning among youths with and without persistent attention-deficit/hyperactivity disorder. Res Dev Disabil. 2013 Jan;34(1):505-15. doi: 10.1016/j.ridd.2012.09.004. Epub 2012 Oct 11.

  PMID: 23063730 DERIVED

• Gau SS, Lin YJ, Cheng AT, Chiu YN, Tsai WC, Soong WT. Psychopathology and symptom remission at adolescence among children with attention-deficit-hyperactivity disorder. Aust N Z J Psychiatry. 2010 Apr;44(4):323-32. doi: 10.3109/00048670903487233.

  PMID: 20307165 DERIVED

MeSH Terms

Conditions

Attention Deficit Disorder with Hyperactivity

Condition Hierarchy (Ancestors)

Attention Deficit and Disruptive Behavior Disorders; Neurodevelopmental Disorders; Mental Disorders

Study Officials

• Susan Shur-Fen Gau, MD, PhD

  National Taiwan University Hospital & College of Medicine

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 31, 2006
• First Posted: January 4, 2007
• Study Start: January 1, 2005
• Study Completion: December 1, 2009
• Last Updated: November 14, 2012

Record last verified: 2012-04

Locations

TW (1)