Sponsor study identifier
observational
240
1 country
1
Study Start
August 1, 2009
Actual (reported)Primary Completion
July 31, 2012
Actual (reported)Study Completion
July 31, 2012
Actual (reported)The ultimate goal of this study is to find the association between specific polymorphism of candidate genes and medication response in attention deficit hyperactivity disorder (ADHD) patients. These results will lead the investigators' team: (1) to resolve controversies over inconsistent findings in previous pharmacogenetic studies; (2) to study the medication effect on the neuropsychological functions that are useful candidate endophenotypes for ADHD; (3) to delineate the nature and the effect of gene-gene interaction in the drug response of ADHD patients.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
July 31, 2012
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
June 8, 2009
Actual (reported)June 10, 2009
Actual (reported)August 1, 2009
Actual (reported)July 31, 2012
Actual (reported)July 31, 2012
Actual (reported)The patients will be randomly assigned to two treatment groups, the OROS-methylphenidate group (n=80) and the atomoxetine group (n=80), respectively.
The patients will be randomly assigned to two treatment groups, the OROS-methylphenidate group (n=80) and the atomoxetine group (n=80), respectively.
Healthy controls matching for the distribution of age and sex of the case groups
The sample will consist of 160 drug-naïve ADHD patients and 80 matched normal controls, aged 7-18. The patients will be randomly assigned to two treatment groups, the OROS-methylphenidate group (n=80) and the atomoxetine group (n=80), respectively.
National Taiwan University Hospital
Taipei, Taiwan
Wu CS, Shang CY, Lin HY, Gau SS. Differential Treatment Effects of Methylphenidate and Atomoxetine on Executive Functions in Children with Attention-Deficit/Hyperactivity Disorder. J Child Adolesc Psychopharmacol. 2021 Apr;31(3):187-196. doi: 10.1089/cap.2020.0146.
Chou TL, Chia S, Shang CY, Gau SS. Differential therapeutic effects of 12-week treatment of atomoxetine and methylphenidate on drug-naive children with attention deficit/hyperactivity disorder: A counting Stroop functional MRI study. Eur Neuropsychopharmacol. 2015 Dec;25(12):2300-10. doi: 10.1016/j.euroneuro.2015.08.024. Epub 2015 Sep 8.
The subjects will receive blood withdrawal. The blood sample will be used for establishing lymphoblastoid cell lines, which will be used for molecular genetic experiments.
Chi-Yung Shang, MD
Dept of Psychiatry, National Taiwan University Hospital
240 participants (actual enrollment reported by the registry).
First Submitted
June 8, 2009
First Posted
June 10, 2009
Study Start
August 1, 2009
Actual (reported)The Effectiveness of Atomoxetine on Brain Imaging, Neuropsychological, and Social Functions in Adults ADHD
Contact the study team to confirm eligibility.
Shang CY, Pan YL, Lin HY, Huang LW, Gau SS. An Open-Label, Randomized Trial of Methylphenidate and Atomoxetine Treatment in Children with Attention-Deficit/Hyperactivity Disorder. J Child Adolesc Psychopharmacol. 2015 Sep;25(7):566-73. doi: 10.1089/cap.2015.0035. Epub 2015 Jul 29.
Primary Completion
July 31, 2012
Actual (reported)Study Completion
July 31, 2012
Actual (reported)Last Updated
September 2, 2021
Record last verified: 2021-09
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