Posterior Pole Asymmetry Analysis (PPAA) for Early Glaucoma

NCT02141594 | Completed

• 1 other identifier: OCT PPAA in early glaucoma
• Study Type: observational
• Target: 156
• Locations: 1 country
• Sites: 1

Brief Summary

Spectrailis optical coherence tomography has come with a new posterior pole asymmetry analysis for glaucoma diagnosis. The aim of the investigators study was to assess its applicability in diagnosing early glaucoma patients.

Conditions

Glaucoma

Outcome Measures

Primary Outcomes (1)

• Area under curve for all the diagnostic parameters of optical coherence tomography

  This was a cross sectional study with one time measurement of the diagnostic parameters of the optical coherence tomography.

  up to 32 weeks

Study Arms (2)

Early glaucoma

The study group consisted of consecutive unilateral glaucoma patients, categorized as early stage by Hodapp-Anderson-Parrish classification.

Normal subjects

Normal control subjects had a normal ocular examination, Intraocular pressure (IOP) \<22 mmHg, no past history of high IOP, no family history of glaucoma, normal optic disc morphology and visual field in both eyes. One eye of control subject was randomly selected.

Eligibility Criteria

• Age: 49 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Consecutive 80 eyes of 80 normal subjects and 76 eyes of 76 patients with early glaucoma were included for the study.

You may qualify if:

• Age more than 18 years
• Best corrected visual acuity 20/40 or better
• Refractive error within ±5D sphere and ±3D cylinder
• Willingness to participate in the study

You may not qualify if:

• Media opacities preventing imaging
• Intraocular surgery within the last 6 months
• Any retinal or neurological disease other than glaucoma that could confound the results of visual field examination and OCT.

Sponsors & Collaborators

• Dr T V Patel Eye Institute: lead

Study Sites (1)

Dr TV Patel Eye Institute

Vadodara, Gujarat, 390001, India

Location

Related Publications (4)

• Mori S, Hangai M, Sakamoto A, Yoshimura N. Spectral-domain optical coherence tomography measurement of macular volume for diagnosing glaucoma. J Glaucoma. 2010 Oct-Nov;19(8):528-34. doi: 10.1097/IJG.0b013e3181ca7acf.

  PMID: 20164794 RESULT

• Nakatani Y, Higashide T, Ohkubo S, Takeda H, Sugiyama K. Evaluation of macular thickness and peripapillary retinal nerve fiber layer thickness for detection of early glaucoma using spectral domain optical coherence tomography. J Glaucoma. 2011 Apr-May;20(4):252-9. doi: 10.1097/IJG.0b013e3181e079ed.

  PMID: 20520570 RESULT

• Seong M, Sung KR, Choi EH, Kang SY, Cho JW, Um TW, Kim YJ, Park SB, Hong HE, Kook MS. Macular and peripapillary retinal nerve fiber layer measurements by spectral domain optical coherence tomography in normal-tension glaucoma. Invest Ophthalmol Vis Sci. 2010 Mar;51(3):1446-52. doi: 10.1167/iovs.09-4258. Epub 2009 Oct 15.

  PMID: 19834029 RESULT

• Rao HL, Babu JG, Addepalli UK, Senthil S, Garudadri CS. Retinal nerve fiber layer and macular inner retina measurements by spectral domain optical coherence tomograph in Indian eyes with early glaucoma. Eye (Lond). 2012 Jan;26(1):133-9. doi: 10.1038/eye.2011.277. Epub 2011 Nov 11.

  PMID: 22079964 RESULT

MeSH Terms

Conditions

Glaucoma

Condition Hierarchy (Ancestors)

Ocular Hypertension; Eye Diseases

Study Officials

• Paaraj R Dave, MS

  Dr TV Patel Eye Institute

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr

Study Record Dates

• First Submitted: May 14, 2014
• First Posted: May 19, 2014
• Study Start: August 1, 2013
• Primary Completion: March 1, 2014
• Study Completion: March 1, 2014
• Last Updated: May 19, 2014

Record last verified: 2014-05

Locations

IN (1)