NCT01841580|Completed
Proteomic Profiles in Trabeculectomy Patients
Long-term Observation of Tear Proteomic Profiles and Ocular Surface in Trabeculectomy Patients Before and After Surgery
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Long-term Observation of Tear Proteomic Profiles and Ocular Surface in Trabeculectomy Patients Before and After Surgery
Sponsor study identifier
Secondary identifiers
OTHER · Singhealth Centralised Institutional Review Board
observational
36
1 country
1
Study Start
November 2013
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
October 2018
Actual (reported)Study Completion
October 2018
Actual (reported)Approximately 70 million people world-wide are affected with glaucoma, of whom 6.7 million have bilateral blindness.5 Elevated intro-ocular pressure is the major modifiable risk factor in glaucoma, and reducing intraocular pressure to a consistently low level can delay disease progression and therefore, blindness.6 Topical intraocular pressure -lowering medication remains the first-line treatment for glaucoma, with surgical intervention playing a secondary role in cases suboptimally controlled with medication alone. In this study, we plan to assess the change in tear proteins in trabeculectomy patients before and after operations. It is hoped that this study could help us gain more understanding of the possible mechanism accounting for the development of dry eye disease in glaucoma patients, which could help us develop better screening modalities and therapeutic agents for glaucoma patients at risk to prevent the development of dry eye disease.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
October 2018
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
April 19, 2013
Actual (reported)April 26, 2013
Actual (reported)November 2013
Date type not reportedThis date has not been verified as actual or estimated.
October 2018
Actual (reported)October 2018
Actual (reported)Change from baseline in the tear protein profiles in trabeculectomy patients at 3 years
Baseline and 3 years
Symptoms and severity of dry eye disease
Baseline and 3 years
Amount of tears will be measured
Baseline and 3 years
Tear Osmolarity will be measured
Baseline and 3 years
Tear meniscus height will be measured
Baseline and 3 years
120 patients will be recruited for this study
Singapore National Eye Centre/ Singapore Eye Research Institute
Singapore, 168751, Singapore
Louis Tong, PhD
Singapore National Eye Centre
36 participants (actual enrollment reported by the registry).
First Submitted
April 19, 2013
First Posted
April 26, 2013
Study Start
November 2013
Date type not reportedThis date has not been verified as actual or estimated.
Ocular Blood Flow Assessment in Glaucoma
Contact the study team to confirm eligibility.
Primary Completion
October 2018
Actual (reported)Study Completion
October 2018
Actual (reported)Last Updated
October 31, 2018
Record last verified: 2018-10
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Source: ClinicalTrials.gov.
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