Ocular Blood Flow Assessment in Glaucoma

NCT02178085 | Completed

• 2 other identifiers: PI2014_843_00072014-A00847-40
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 2

Brief Summary

Background : Glaucoma is a common disease, potentially blinding, characterized by progressive damage to the optic nerve. If the intraocular pressure is the most known risk factor, however, there are cases of glaucoma scalable despite well-controlled intraocular pressure, ocular hypertension without glaucoma or glaucoma without ocular hypertension (normal tension glaucoma). Purpose :Involvement of vascular factors in the development of glaucoma and scalability has been proved, associated with a possible loss of vascular autoregulation. The objective of this study is to quantify MRI flow of blood flows referred ophthalmic patients with glaucoma untreated comparison with control subjects.

Conditions

Glaucoma

Keywords

glaucoma; phase-contrast MRI; blood flow; cerebrospinal fluid

Outcome Measures

Primary Outcomes (1)

• Arterial blood flow

  Measure of the mean arterial blood flow during the cardiac cycle in the ophthalmic artery.

  Day 1

Secondary Outcomes (3)

• Vascular flow curves

  Day 1

• Cerebrospinal fluid (CSF) dynamic

  Day 1

• Treatment response

  Day 180

Study Arms (1)

Flow imaging

EXPERIMENTAL

Glaucoma patients and healthy subjects who will undergo ocular flow imaging

Other: Flow imaging

Interventions

Flow imaging OTHER

Participants will undergo morphological and then flow MRI. Flow MR images will be processed adequately to obtain quantitative values of arterial and venous flow as well as CSF flow.

Also known as: Flow MRI, Cine phase-constrast magnetic resonance imaging, Cerebral blood flow

Flow imaging

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adult participants
• Diagnosis of primary open angle glaucoma or normal-tension glaucoma
• Never received any anti glaucoma therapy
• Patients included in the group " normal pressure glaucoma " are patients where the diagnosis of optic neuropathy have been worn by the ophthalmologist with measured intraocular pressure \<21 mmHg.

You may not qualify if:

• Anyone with a classic contraindication to MRI
• Cardiovascular comorbidities or neurovascular : uncontrolled systemic hypertension , Diabetes, heart failure , carotid stenosis , ischemic stroke or transient ischemic attack.
• Already treated glaucoma
• Prescription by the ophthalmologist another treatment than prostaglandin analogue treatment.
• Other clinical forms of glaucoma : angle closure glaucoma, neovascular glaucoma, exfoliative glaucoma, secondary glaucomas, pigment dispersion glaucoma, traumatic glaucoma, congenital glaucoma
• History of intraocular or orbital surgery of less than 6 months .

Sponsors & Collaborators

• Centre Hospitalier Universitaire, Amiens: lead

Study Sites (2)

CHU Amiens

Amiens, Picardie, 80054, France

Location

Centre d'ophtalmologie Victor Pauchet

Amiens, Picardie, 80090, France

Location

MeSH Terms

Conditions

Glaucoma

Interventions

Cerebrovascular Circulation

Condition Hierarchy (Ancestors)

Ocular Hypertension; Eye Diseases

Intervention Hierarchy (Ancestors)

Blood Circulation; Cardiovascular Physiological Phenomena; Circulatory and Respiratory Physiological Phenomena

Study Officials

• Olivier Balédent, PhD

  CHU Amiens

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 18, 2014
• First Posted: June 30, 2014
• Study Start: March 5, 2015
• Primary Completion: March 26, 2020
• Study Completion: March 26, 2020
• Last Updated: June 11, 2026

Record last verified: 2026-06

Locations

FR (2)