HDL-C in Cardiac Syndrome X

NCT02095964 | Completed DMC

• 1 other identifier: BYIEAH-281
• Study Type: observational
• Target: 710
• Locations: 0 countries
• Sites: N/A

Brief Summary

High density lipoprotein cholesterol (HDL-C) is in the centrum of the process of reverse cholesterol transport from peripheral cells to the liver\[10\]. HDL-C promotes endothelial generation of nitric oxide (NO) and improves endothelial function and arterial vasoreactivity\[11\]. In several studies, lower HDL-C level was reported to be associated with increased coronary artery disease (CAD) risk\[12-14\]. HDL-C also has anti- inflammatory and anti-oxidant activities\[15,16\]. Concerning anti-inflammatory activity, HDL-C inhibits the activation of monocytes/macrophages and neutrophils\[17,18\] and inhibits the expression of endothelial adhesion molecules, such as vascular cell adhesion molecule-1 (VCAM-1) and E-selectin\[15\]. In this study we aimed to investigate the relation of HDL-C level with systemic inflammatory markers in patients with cardiac syndrome X (CSX).

Conditions

Cardiovascular Diseases; Heart Diseases; Myocardial Ischaemia; Unstable Angina; Microvascular Angina

Keywords

cardiac syndrome X; inflammation; dyslipidemia

Outcome Measures

Primary Outcomes (3)

• HDL-Cholesterol

  HDL-Cholesterol \<40 mg/dL(male) / \< 50mg/dL(female) ==\> low HDL-C

  6 MONTHS

• Cardiac Syndrome X

  Patients who have typical anginal chest pain+ischaemic findings at exercise stress test/myocardial scintigraphy + normal epicardial coronaries at coronary angiography ==\> Cardiac syndrome X

  6 months

• Inflammation

  CRP \> 2,98 mg/dL ==\> systemic inflammation

  6 months

Study Arms (2)

Cardiac Syndrome X

Control Group

Eligibility Criteria

• Age: 47 Years - 58 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

CSX was defined as typical chest pain during rest or effort, abnormal test result for exercise ECG and myocardial perfusion scintigraphy, and the presence of angiographically normal epicardial coronary arteries. Control group was selected from volunteers presented to our hospital with the complaint of typical anginal chest pain who had no ischemia on myocardial perfusion scintigraphy or during the treadmill exercise test, had similar risk profile with the patients (diabetes, hypertension, age, gender) and had normal epicardial coronaries at coronary angiography.

You may qualify if:

• Must be able to get exercise stress test
• Must be able to have coronary angiography
• Clinical diagnosis of typical anginaduring rest or effort
• Abnormal test result for exercise ECG or myocardial perfusion scintigraphy
• Must have of angiographically normal epicardial coronary arteries

You may not qualify if:

• Patients with valvular heart disease (mitral stenosis and moderate to severe mitral regurgitation
• Patients with moderate to severe aortic stenosis and regurgitation including mitral annular calcification)
• Patients with heart failure (left ventricular ejection fraction \<50%)
• Patients with congenital heart disease, cardiomyopathy, left ventricular hypertrophy, right ventricular hypertrophy
• Patients with cardiac surgery
• Patients with thyroid disease
• Patients with anemia
• Patients with pulmonary diseases
• Patients with infectious diseases (locally or systemic)

Sponsors & Collaborators

• Bursa Yuksek Ihtisas Training and Research Hospital: lead

MeSH Terms

Conditions

Cardiovascular Diseases; Heart Diseases; Coronary Artery Disease; Angina, Unstable; Microvascular Angina; Inflammation; Dyslipidemias

Condition Hierarchy (Ancestors)

Coronary Disease; Myocardial Ischemia; Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases; Angina Pectoris; Chest Pain; Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Pathologic Processes; Lipid Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CROSSOVER
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 17, 2014
• First Posted: March 26, 2014
• Study Start: March 1, 2012
• Primary Completion: December 1, 2013
• Study Completion: January 1, 2014
• Last Updated: March 26, 2014

Record last verified: 2014-03