NCT00035737

Brief Summary

To investigate the role of endothelial dysfunction and increased vascular stiffness as contributors to the pathogenesis of cardiovascular disease.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Timeline
Completed

Started May 2002

Longer than P75 for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

May 1, 2002

Completed
3 days until next milestone

First Submitted

Initial submission to the registry

May 4, 2002

Completed
2 days until next milestone

First Posted

Study publicly available on registry

May 6, 2002

Completed
4.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 1, 2007

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

March 1, 2007

Completed
Last Updated

February 21, 2014

Status Verified

February 1, 2014

Enrollment Period

4.8 years

First QC Date

May 4, 2002

Last Update Submit

February 20, 2014

Conditions

Cardiovascular DiseasesHeart Diseases

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
No eligibility criteria

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Related Publications (5)

  • Vita JA, Keaney JF Jr, Larson MG, Keyes MJ, Massaro JM, Lipinska I, Lehman BT, Fan S, Osypiuk E, Wilson PW, Vasan RS, Mitchell GF, Benjamin EJ. Brachial artery vasodilator function and systemic inflammation in the Framingham Offspring Study. Circulation. 2004 Dec 7;110(23):3604-9. doi: 10.1161/01.CIR.0000148821.97162.5E. Epub 2004 Nov 29.

    PMID: 15569842BACKGROUND

  • Benjamin EJ, Larson MG, Keyes MJ, Mitchell GF, Vasan RS, Keaney JF Jr, Lehman BT, Fan S, Osypiuk E, Vita JA. Clinical correlates and heritability of flow-mediated dilation in the community: the Framingham Heart Study. Circulation. 2004 Feb 10;109(5):613-9. doi: 10.1161/01.CIR.0000112565.60887.1E.

    PMID: 14769683BACKGROUND

  • Vita JA. Endothelial function and clinical outcome. Heart. 2005 Oct;91(10):1278-9. doi: 10.1136/hrt.2005.061333. No abstract available.

    PMID: 16162617BACKGROUND

  • Vita JA, Mitchell GF. Effects of shear stress and flow pulsatility on endothelial function: insights gleaned from external counterpulsation therapy. J Am Coll Cardiol. 2003 Dec 17;42(12):2096-8. doi: 10.1016/j.jacc.2003.09.020. No abstract available.

    PMID: 14680733BACKGROUND

  • Ganz P, Vita JA. Testing endothelial vasomotor function: nitric oxide, a multipotent molecule. Circulation. 2003 Oct 28;108(17):2049-53. doi: 10.1161/01.CIR.0000089507.19675.F9. No abstract available.

    PMID: 14581383BACKGROUND

MeSH Terms

Conditions

Cardiovascular DiseasesHeart Diseases

Study Officials

  • Emelia Benjamin

    Boston University

Study Design

Study Type
observational
Sponsor Type
OTHER

Study Record Dates

First Submitted

May 4, 2002

First Posted

May 6, 2002

Study Start

May 1, 2002

Primary Completion

March 1, 2007

Study Completion

March 1, 2007

Last Updated

February 21, 2014

Record last verified: 2014-02