NCT00006295|Completed
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Sponsor study identifier
Secondary identifiers
NIH
observational
370
0 countries
N/A
Study Start
August 2000
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
July 2006
Actual (reported)Study Completion
July 2006
Actual (reported)To study the genetic cause of low HDL-C, a risk factor for premature atherosclerotic vascular disease in patients with normal total cholesterol. The focus is primarily on the identification of a single mutation, as has been demonstrated in one family.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
July 2006
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
August 2000
Date type not reportedThis date has not been verified as actual or estimated.
September 25, 2000
Actual (reported)September 26, 2000
Actual (reported)July 2006
Actual (reported)July 2006
Actual (reported)Gene discovery
20 years
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Hong SH, Riley W, Rhyne J, Friel G, Miller M. Lack of association between increased carotid intima-media thickening and decreased HDL-cholesterol in a family with a novel ABCA1 variant, G2265T. Clin Chem. 2002 Nov;48(11):2066-70.
Hong SH, Rhyne J, Zeller K, Miller M. ABCA1(Alabama): a novel variant associated with HDL deficiency and premature coronary artery disease. Atherosclerosis. 2002 Oct;164(2):245-50. doi: 10.1016/s0021-9150(02)00106-5.
First Submitted
September 25, 2000
First Posted
September 26, 2000
Study Start
August 2000
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
July 2006
Ho Hong S, Rhyne J, Zeller K, Miller M. Novel ABCA1 compound variant associated with HDL cholesterol deficiency. Biochim Biophys Acta. 2002 May 21;1587(1):60-4. doi: 10.1016/s0925-4439(02)00066-2.
Miller M, Zhan M, Georgopoulos A. Effect of desirable fasting triglycerides on the postprandial response to dietary fat. J Investig Med. 2003 Feb;51(1):50-5. doi: 10.2310/6650.2003.33544.
Friend M, Vucenik I, Miller M. Research pointers: Platelet responsiveness to aspirin in patients with hyperlipidaemia. BMJ. 2003 Jan 11;326(7380):82-3. doi: 10.1136/bmj.326.7380.82. No abstract available.
Miller M. Niacin as a component of combination therapy for dyslipidemia. Mayo Clin Proc. 2003 Jun;78(6):735-42. doi: 10.4065/78.6.735.
Miller M, Zhan M. Genetic determinants of low high-density lipoprotein cholesterol. Curr Opin Cardiol. 2004 Jul;19(4):380-4. doi: 10.1097/01.hco.0000126584.12520.b5.
Hong SH, Rhyne J, Miller M. Novel polypyrimidine variation (IVS46: del T -39...-46) in ABCA1 causes exon skipping and contributes to HDL cholesterol deficiency in a family with premature coronary disease. Circ Res. 2003 Nov 14;93(10):1006-12. doi: 10.1161/01.RES.0000102957.84247.8F. Epub 2003 Oct 23.
Ahmad I, Zhan M, Miller M. High prevalence of C-reactive protein elevation with normal triglycerides (100-149 mg/dL): are triglyceride levels below 100 mg/dL more optimal in coronary heart disease risk assessment? Am J Med Sci. 2005 Apr;329(4):173-7. doi: 10.1097/00000441-200504000-00002.
Miller M, Zhan M, Havas S. High attributable risk of elevated C-reactive protein level to conventional coronary heart disease risk factors: the Third National Health and Nutrition Examination Survey. Arch Intern Med. 2005 Oct 10;165(18):2063-8. doi: 10.1001/archinte.165.18.2063.
Study Completion
July 2006
Actual (reported)Last Updated
January 14, 2020
Record last verified: 2020-01
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