RePox-1
Does Correction of Exercice-induced Desaturation by O2 Improve Systematically Exercise Tolerance in COPD Patients ?
Sponsor study identifier
observational
255
1 country
2
Study Start
February 2014
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
February 2014
Actual (reported)Study Completion
July 2015
Actual (reported)In the literature, the effects of acute oxygen administration on exercise tolerance and related symptoms have often appeared to be contradictory. Some investigations have reported benefits from acute oxygen supply during exertion, including increased exercise performance, reduced dyspnea, and better cardiorespiratory adaptations, whereas other studies have reported no improvement. Recently, we advanced then the hypothesis that some patients would be non-responders and even worsen under oxygen treatment. The preliminary results confirmed our hypothesis since we demonstrated that while 56% of the patients were improved with supplemental oxygen, 16% were non-responders and 28% were negative-responders (decreased performance and increased dyspnea during endurance exercise with supplemental oxygen). However, this was a pilot study offering preliminary insights and tentative conclusions that must be confirmed in a larger case series. The aims of this retrospective study was :
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
July 2015
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
February 2014
Date type not reportedThis date has not been verified as actual or estimated.
February 2014
Actual (reported)February 4, 2014
Actual (reported)February 5, 2014
Actual (reported)July 2015
Actual (reported)Distance of six minute walking test (meter)
Baseline
Dyspnea during the 6 minute walking test
Baseline
Positive responders (R+): patients exhibiting an increase in the 6WT distance ≥ 10% and/or a decrease in dyspnea ≥ 10% (i.e., ≥ 1 point on the visual analogue scale).
Negative responders(R-): patients exhibiting a decrease in the distance ≥ 10% and/or an increase in dyspnea ≥ 10%.
Patients with chronic obstructive pulmonary disease and exhibiting an exercise-induced desaturation during six minute walkink test.
Clinique du Souffle La Vallonie
Lodève, 34800, France
Clinique du Souffle La Solane
Osséjà, 66340, France
Heraud N, Prefaut C, Durand F, Varray A. Does correction of exercise-induced desaturation by O(2) always improve exercise tolerance in COPD? A preliminary study. Respir Med. 2008 Sep;102(9):1276-86. doi: 10.1016/j.rmed.2008.04.005. Epub 2008 Jul 10.
Nelly N HERAUD, Pd-D
5 Santé
255 participants (actual enrollment reported by the registry).
First Submitted
February 4, 2014
First Posted
February 5, 2014
Study Start
February 2014
Date type not reportedThis date has not been verified as actual or estimated.
Benefits of Liquid Oxygen in COPD Patients Presenting Desaturation During Exercise.
Contact the study team to confirm eligibility.
Primary Completion
February 2014
Actual (reported)Study Completion
July 2015
Actual (reported)Last Updated
July 8, 2015
Record last verified: 2015-07
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Source: ClinicalTrials.gov.
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