NCT02529891|Terminated
Study Stopped
Lack of inclusion
Identification of Volatile Organic Compounds in Exhaled Air During Exacerbation of Chronic Obstructive Pulmonary Disease
LAVOLEX
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Sponsor study identifier
Secondary identifiers
OTHER · ANSM
observational
19
1 country
1
Study Start
August 8, 2014
Actual (reported)Primary Completion
October 17, 2017
Actual (reported)Study Completion
October 17, 2017
Actual (reported)Exacerbations of the disease are a hallmark of Chronic Obstructive Pulmonary Disease (COPD), affecting the decline of pulmonary function, quality of life and increasing morbidity. The use of validated biomarkers could help to identify the etiology of exacerbation and to prescribe antibiotherapy when indicated. The analysis of exhaled air allows measuring different volatile organic compounds (VOC) which reflect local or systemic inflammation and oxidative stress. The relationship between the presence of some of these compounds and the exacerbation of COPD has never been studied. The aim of this study is to identify a cluster of VOC in COPD patients during an acute exacerbation of the disease, compared to a stable condition (3 months after discharge). Investigators also will seek for a relationship between VOC and the etiology of exacerbation (bacterial, viral, inflammatory).
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
October 17, 2017
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
August 8, 2014
Actual (reported)August 19, 2015
Actual (reported)August 20, 2015
Actual (reported)October 17, 2017
Actual (reported)October 17, 2017
Actual (reported)Spectrum of VOC measured with a portable mass spectrometer system
Spectrum of VOC in exhaled air in patients with COPD compared to those of control subjects. It is measured with a portable mass spectrometer system.
Day 1 (within 48 hours after hospital admission for exacerbation of COPD)
Variation in VOC spectrum in COPD patients measured with a portable mass spectrometer system
3 months after hospital discharge
Patients with COPD, within 48h after hospital admission for exacerbation.
Healthy person of the entourage of COPD patients.
Measurement of VOC in exhaled air during 10 min (tidal breathing) with a portable mass spectrometer
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Patients with exacerbation of COPD and Healthy volonteers
CHU de SAINT-ETIENNE
Saint-Etienne, 42000, France
Frederic COSTES, MD PhD
CHU de SAINT-ETIENNE
19 participants (actual enrollment reported by the registry).
First Submitted
August 19, 2015
First Posted
August 20, 2015
Study Start
August 8, 2014
Actual (reported)Pain Assessment in Patients With Chronic Obstructive Pulmonary Disease (COPD) Exacerbations.
Contact the study team to confirm eligibility.
Primary Completion
October 17, 2017
Actual (reported)Study Completion
October 17, 2017
Actual (reported)Last Updated
October 19, 2017
Record last verified: 2017-10
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Source: ClinicalTrials.gov.
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