NCT02053701

Brief Summary

Magnetic resonance spectroscopy (MRS) allows non-invasive measurement of the concentration of up to 18 metabolites in the brain ("neurochemical profile"). The objective of this proposal is to develop new methods for high-field brain MRS (3 to 7 Tesla). Our main hypothesis is that higher magnetic fields lead to improved spatial and temporal resolution and improved quantification precision. Aims

  1. 1.To obtain improved "neurochemical profiles" in the brain using single voxel proton MRS at very high field (3 Tesla to 7 Tesla).
  2. 2.To develop new methods for proton magnetic resonance spectroscopic imaging (MRSI) to obtain metabolic maps at very high field (3 Tesla to 7 Tesla).

Trial Health

75
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
30

participants targeted

Target at below P25 for all trials

Timeline
54mo left

Started Jun 2010

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
active not recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress79%
Jun 2010Nov 2030

Study Start

First participant enrolled

June 1, 2010

Completed
3.7 years until next milestone

First Submitted

Initial submission to the registry

January 29, 2014

Completed
6 days until next milestone

First Posted

Study publicly available on registry

February 4, 2014

Completed
16.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 1, 2030

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

November 1, 2030

Last Updated

March 19, 2026

Status Verified

March 1, 2026

Enrollment Period

20.4 years

First QC Date

January 29, 2014

Last Update Submit

March 16, 2026

Conditions

Healthy

Keywords

magnetic resonance spectroscopyquantification precisionbrainbrain metabolites

Outcome Measures

Primary Outcomes (1)

  • Precision of quantification of brain metabolites concentrations

    This protocol is devoted exclusively to technical development and testing of MRS methods on our MR scanners. As such, there is no well-defined outcome measure or time frame. It is a continuous effort. We recruit subjects on an ongoing basis to test, optimize, and assess the performance of newly developed techniques.

    One time only

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

healthy subjects

You may qualify if:

  • over 18 years old

You may not qualify if:

  • no metallic implant or other MRI-incompatible device

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Center for Magnetic Resonance Research

Minneapolis, Minnesota, 55455, United States

Location

Study Officials

  • Pierre-Gilles Henry, PhD

    Center for Magnetic Resonance Research, University of Minnesota

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
OTHER
Time Perspective
OTHER
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

January 29, 2014

First Posted

February 4, 2014

Study Start

June 1, 2010

Primary Completion (Estimated)

November 1, 2030

Study Completion (Estimated)

November 1, 2030

Last Updated

March 19, 2026

Record last verified: 2026-03

Locations

US(1)