Evaluation of Skeletal Muscle Lipid Content by Magnetic Resonance Spectroscopy

NCT00786578 | Withdrawn

• 2 other identifiers: 0708M139415K12RR023247-02
• Study Type: observational
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

Type 2 diabetes is a growing public health issue and one component of Type 2 diabetes is 'insulin resistance" - the ability of insulin to work less well. The skeletal muscle is one of the largest users of sugar in the body, when the skeletal muscle is "insulin resistant", this contributes to diabetes. There is some evidence that the amount of fat in the skeletal muscle is related to the amount of insulin resistance. We are asking people to participate in a study to look at the amount of fat in muscle and how this fat amount changes with exercise. We hypothesize that heavier people will have higher amounts of fat and deplete this fat more slowly than lean subjects.

Conditions

Healthy

Keywords

training; intramyocellular lipid; insulin resistance

Outcome Measures

Primary Outcomes (1)

• absolute change in intramyocellular lipid quantity with exercise

  over 4 months

Study Arms (2)

1

overweight runners (BMI\>25)

2

lean runners (BMI\<24)

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Healthy subjects on regular running program.

You may qualify if:

• Age range will be from age 18 to 45. We will be limiting the upper age range because increased age is associated with sarcopenia and alteration of fiber type.
• We will define the lean trained group by a BMI of \< 24 kg/m2. We will define the overweight group as BMI \> 26 25 kg/m2.
• The subjects should be participating in regular running exercise (\> 30 min/day, ≥ 5 days/week).
• Weight must be stable \[+/- 5 pounds\] for at least the three months prior to the study for all participants.

You may not qualify if:

• The subjects must not be on medications that may affect lipid levels, specifically lipid lowering agents, birth control pills, or diuretics.
• The subjects should not be on a high fat diet (\> 45% fat) as measured by a screening questionnaire.
• The subject must not have any contraindications to magnetic resonance imaging.

Sponsors & Collaborators

• University of Minnesota: lead
• National Center for Research Resources (NCRR): collaborator

Study Sites (1)

Univeresity of Minnesota

Minneapolis, Minnesota, 55455, United States

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

blood will be sampled and retained for future metabolic testing as needed

MeSH Terms

Conditions

Insulin Resistance

Condition Hierarchy (Ancestors)

Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases

Study Officials

• Lisa S Chow

  University of Minnesota

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 5, 2008
• First Posted: November 6, 2008
• Study Start: January 1, 2010
• Primary Completion: January 1, 2014
• Study Completion: January 1, 2014
• Last Updated: October 24, 2014

Record last verified: 2014-10

Locations

US (1)