Dimethyl Fumarate (DMF) Observational Study
ESTEEM
A Multicenter, Global, Observational Study to Collect Information on Safety and to Document the Drug Utilization of Tecfidera™ (Dimethyl Fumarate) When Used in Routine Medical Practice in the Treatment of Multiple Sclerosis (ESTEEM)
1 other identifier
observational
5,487
21 countries
447
Brief Summary
The primary objective of the study is to determine the incidence, type, and pattern of serious adverse events (SAEs), including but not limited to infections (including opportunistic infections), hepatic events, malignancies, and renal events, and of adverse events (AEs) leading to treatment discontinuation in patients with MS treated with dimethyl fumarate (DMF). Secondary objectives of this study in this population are as follows: To determine dimethyl fumarate (DMF) prescription and utilization patterns in routine clinical practice in patients with multiple sclerosis (MS); To assess the effectiveness of dimethyl fumarate (DMF) on multiple sclerosis (MS) disease activity and disability progression in routine clinical practice as determined by the Expanded Disability Status Scale (EDSS) score and multiple sclerosis (MS) relapse information; and To assess the effect of dimethyl fumarate (DMF) on health-related quality of life, healthcare resource consumption, and work productivity.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Nov 2013
Longer than P75 for all trials
447 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
November 19, 2013
CompletedFirst Submitted
Initial submission to the registry
January 24, 2014
CompletedFirst Posted
Study publicly available on registry
January 28, 2014
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 31, 2022
CompletedStudy Completion
Last participant's last visit for all outcomes
October 31, 2022
CompletedMay 24, 2023
May 1, 2023
9 years
January 24, 2014
May 23, 2023
Conditions
Outcome Measures
Primary Outcomes (2)
The number of participants that experience Adverse Events (AEs) that lead to discontinuation of dimethyl fumarate (DMF)
Up to 5 years
The number of participants that experience Serious Adverse Events (SAEs)
Up to 5 years
Secondary Outcomes (12)
Duration of dimethyl fumarate (DMF) use
Up to 5 years
dimethyl fumarate (DMF) dosing frequency
Up to 5 years
Primary reasons for discontinuation of dimethyl fumarate (DMF) use
Up to 5 years
Frequency of relapses over time
Up to 5 years
Disease progression as measured by Expanded Disability Status Scale (EDSS) over time
Up to 5 years
- +7 more secondary outcomes
Study Arms (1)
dimethyl fumarate (DMF)
Patients with multiple sclerosis receiving dimethyl fumarate (DMF) under routine clinical care
Interventions
Provided under routine clinical care
Eligibility Criteria
Patients undergoing routine clinical care for Multiple Sclerosis.
You may qualify if:
- \- Patients with multiple sclerosis (MS) who are newly initiating treatment with dimethyl fumarate (DMF) under routine clinical care are eligible to participate in the study.
You may not qualify if:
- Patients with previous exposure to dimethyl fumarate (DMF), Fumaderm (fumaric acid esters), or compounded fumarates.
- Patients participating in other clinical studies.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Biogenlead
Study Sites (468)
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Birmingham, Alabama, 35209, United States
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Huntsville, Alabama, 35801, United States
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Gilbert, Arizona, 85234, United States
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Phoenix, Arizona, 85006, United States
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Phoenix, Arizona, 85018, United States
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Phoenix, Arizona, 85048, United States
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Scottsdale, Arizona, 85251, United States
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Tucson, Arizona, 85718, United States
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Fullerton, California, 92835, United States
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Hanford, California, 93230, United States
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Loma Linda, California, 92354, United States
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Los Angeles, California, 90015, United States
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Los Angeles, California, 90048, United States
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Newport Beach, California, 92663, United States
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San Francisco, California, 94158, United States
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Santa Ana, California, 92704, United States
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Aurora, Colorado, 80045, United States
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Colorado Springs, Colorado, 80907, United States
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Denver, Colorado, 80210, United States
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Fort Collins, Colorado, 80528, United States
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Danbury, Connecticut, 06810, United States
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Derby, Connecticut, 06418, United States
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Hartford, Connecticut, 06112, United States
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Norwich, Connecticut, 06360, United States
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Dover, Delaware, 19901, United States
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Wilmington, Delaware, 19801, United States
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Washington D.C., District of Columbia, 20007, United States
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Washington D.C., District of Columbia, 20037, United States
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Boca Raton, Florida, 33486, United States
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Gainesville, Florida, 32610, United States
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Jacksonville, Florida, 32216, United States
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Lighthouse PT, Florida, 33064, United States
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Maitland, Florida, 32751, United States
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Miami, Florida, 33125, United States
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Port Charlotte, Florida, 33952, United States
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Sarasota, Florida, 34233, United States
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St. Petersburg, Florida, 33710, United States
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St. Petersburg, Florida, 33713, United States
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Tampa, Florida, 33606, United States
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Atlanta, Georgia, 30309, United States
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Atlanta, Georgia, 30309, United States
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Atlanta, Georgia, 30327, United States
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Augusta, Georgia, 30912, United States
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Columbus, Georgia, 31909, United States
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Savannah, Georgia, 31406, United States
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Chicago, Illinois, 60611, United States
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Chicago, Illinois, 60637, United States
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Evanston, Illinois, 60201, United States
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Herrin, Illinois, 62948, United States
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Peoria, Illinois, 61603, United States
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Winfield, Illinois, 60190, United States
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Elkhart, Indiana, 46514, United States
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Indianapolis, Indiana, 46202, United States
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Des Moines, Iowa, 50309, United States
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Des Moines, Iowa, 50314, United States
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Waterloo, Iowa, 50702, United States
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Overland Park, Kansas, 66211, United States
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Overland Park, Kansas, 66212, United States
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Henderson, Kentucky, 42420, United States
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Louisville, Kentucky, 40207, United States
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Hammond, Louisiana, 70403, United States
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New Orleans, Louisiana, 70121, United States
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Rockport, Maine, 04856, United States
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Baltimore, Maryland, 21201, United States
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Baltimore, Maryland, 21287, United States
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Bethesda, Maryland, 20814, United States
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Cumberland, Maryland, 21502, United States
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Glen Burnie, Maryland, 21061, United States
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Boston, Massachusetts, 02111, United States
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Boston, Massachusetts, 02135, United States
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Foxborough, Massachusetts, 02035, United States
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Jamaica Plain, Massachusetts, 02130, United States
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Lexington, Massachusetts, 02421, United States
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Wellesley, Massachusetts, 02481, United States
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Worcester, Massachusetts, 01655, United States
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Ann Arbor, Michigan, 48109, United States
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East Lansing, Michigan, 48824, United States
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Farmington Hills, Michigan, 48334, United States
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West Bloomfield, Michigan, 48322, United States
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Edina, Minnesota, 55435, United States
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Minneapolis, Minnesota, 55407, United States
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Ocean Springs, Mississippi, 39564, United States
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Springfield, Missouri, 65806, United States
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St Louis, Missouri, 63110, United States
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Billings, Montana, 59101, United States
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Great Falls, Montana, 59405, United States
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Lincoln, Nebraska, 68506, United States
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Lincoln, Nebraska, 68521, United States
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Wahoo, Nebraska, 68066, United States
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Las Vegas, Nevada, 89106, United States
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Concord, New Hampshire, 03301, United States
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Audubon, New Jersey, 08106, United States
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Flemington, New Jersey, 08822, United States
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Hackensack, New Jersey, 07601, United States
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Livingston, New Jersey, 07039, United States
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New Brunswick, New Jersey, 08903, United States
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Newark, New Jersey, 07103, United States
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Stratford, New Jersey, 08084, United States
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Toms River, New Jersey, 08755, United States
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West Long Branch, New Jersey, 07764, United States
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Albany, New York, 12206, United States
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Cedarhurst, New York, 11516, United States
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East Meadow, New York, 11554, United States
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Kingston, New York, 12401, United States
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New York, New York, 10016, United States
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New York, New York, 10029, United States
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Patchogue, New York, 11772, United States
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Plainview, New York, 11803, United States
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Syracuse, New York, 13202, United States
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Syracuse, New York, 13210, United States
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Asheville, North Carolina, 28803, United States
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Charlotte, North Carolina, 28204, United States
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Charlotte, North Carolina, 28226, United States
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Greensboro, North Carolina, 27405, United States
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Hendersonville, North Carolina, 28792, United States
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Pinehurst, North Carolina, 28370, United States
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Raleigh, North Carolina, 27607, United States
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Wilmington, North Carolina, 28401, United States
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Winston-Salem, North Carolina, 27157, United States
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Bismarck, North Dakota, 58501, United States
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Canton, Ohio, 44735, United States
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Centerville, Ohio, 45459, United States
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Cincinnati, Ohio, 45267, United States
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Cleveland, Ohio, 44195, United States
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Columbus, Ohio, 43210, United States
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Oklahoma City, Oklahoma, 73104, United States
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Tulsa, Oklahoma, 74136, United States
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Portland, Oregon, 97225, United States
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Portland, Oregon, 97239, United States
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Abington, Pennsylvania, 19001, United States
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Allentown, Pennsylvania, 18103, United States
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Greensburg, Pennsylvania, 15601, United States
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Meadowbrook, Pennsylvania, 19046, United States
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Monroeville, Pennsylvania, 15146, United States
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Natrona Heights, Pennsylvania, 15065, United States
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Philadelphia, Pennsylvania, 19107, United States
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Pittsburgh, Pennsylvania, 15212, United States
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Columbia, South Carolina, 29203, United States
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Greenville, South Carolina, 29605, United States
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Spartanburg, South Carolina, 29307, United States
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Franklin, Tennessee, 37064, United States
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Knoxville, Tennessee, 37920, United States
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Knoxville, Tennessee, 37922, United States
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Nashville, Tennessee, 37205, United States
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Nashville, Tennessee, 37232, United States
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Arlington, Texas, 76012, United States
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Colleyville, Texas, 76034, United States
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Dallas, Texas, 75246, United States
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Dallas, Texas, 75390, United States
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Houston, Texas, 77030, United States
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Norfolk, Virginia, 23502, United States
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Richmond, Virginia, 23298, United States
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Virginia Beach, Virginia, 23456, United States
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Kirkland, Washington, 98034, United States
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Seattle, Washington, 98101, United States
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Spokane, Washington, 99208, United States
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Tacoma, Washington, 98405, United States
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Tacoma, Washington, 98409, United States
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Green Bay, Wisconsin, 54301, United States
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Green Bay, Wisconsin, 54303, United States
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Green Bay, Wisconsin, 54308, United States
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Green Bay, Wisconsin, 54311, United States
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La Crosse, Wisconsin, 54601, United States
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Madison, Wisconsin, 53715, United States
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Milwaukee, Wisconsin, 53211, United States
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Milwaukee, Wisconsin, 53215, United States
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Neenah, Wisconsin, 54956, United States
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Waukesha, Wisconsin, 53188, United States
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Ciudad Autonoma Buenos Aires, Buenos Aires, C1181ACH, Argentina
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Ciudad Autonoma de Buenos Aires, Buenos Aires, C1061ABD, Argentina
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Ciudad Autonoma de Buenos Aires, Buenos Aires, C1425DKT, Argentina
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Vicente López, Buenos Aires, 1602, Argentina
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Rosario, Santa Fe Province, S2000DFD, Argentina
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Rosario, Santa Fe Province, S2000, Argentina
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San Miguel de Tucumán, Tucumán Province, 4000, Argentina
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Ciudad Autonoma Buenos Aires, 1199, Argentina
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Ciudad Autonoma Buenos Aires, C1013AAB, Argentina
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Ciudad Autonoma Buenos Aires, C1118AAT, Argentina
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Ciudad Autonoma Buenos Aires, C1192AAW, Argentina
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Córdoba, 5000, Argentina
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Córdoba, X5004CDT, Argentina
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Mendoza, M5502AWY, Argentina
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Salta, 4400, Argentina
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San Juan, 5400, Argentina
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Santiago del Estero, 4200, Argentina
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Villa Nueva, 5519, Argentina
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Camperdown, New South Wales, 2050, Australia
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Concord, New South Wales, 2139, Australia
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Kogarah, New South Wales, 2217, Australia
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Liverpool, New South Wales, 2170, Australia
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New Lambton Heights, New South Wales, 2305, Australia
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Randwick, New South Wales, 2031, Australia
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St Leonards, New South Wales, 2065, Australia
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Sydney, New South Wales, 2109, Australia
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Westmead, New South Wales, 2145, Australia
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Auchenflower, Queensland, 4066, Australia
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Gold Coast, Queensland, 9726, Australia
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Bedford Park, South Australia, 5042, Australia
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Kent Town, South Australia, 5067, Australia
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Box Hill, Victoria, 3128, Australia
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Clayton, Victoria, 3168, Australia
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Geelong, Victoria, 3220, Australia
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Heidelberg, Victoria, 3084, Australia
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Melbourne, Victoria, 3004, Australia
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Melbourne, Victoria, 3181, Australia
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Parkville, Victoria, 3050, Australia
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Nedlands, Western Australia, 6009, Australia
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Amstetten, 3300, Austria
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Salzburg, 5020, Austria
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Vienna, 1040, Austria
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Vienna, 1180, Austria
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Calgary, Alberta, T2N 2T9, Canada
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Burnaby, British Columbia, V5H 4K7, Canada
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Victoria, British Columbia, V8R 1J8, Canada
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Moncton, New Brunswick, E1C 6Z8, Canada
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Halifax, Nova Scotia, B3H 1V7, Canada
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Sydney, Nova Scotia, B1P 1P3, Canada
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Cambridge, Ontario, N1R7L6, Canada
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London, Ontario, N6A 5A5, Canada
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Milton, Ontario, L9T 5B5, Canada
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Scarborough Village, Ontario, M1R 3A6, Canada
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Thunder Bay, Ontario, P7B 6V4, Canada
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Gatineau, Quebec, J8Y 1W2, Canada
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Montreal, Quebec, H2L 4M1, Canada
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Montreal, Quebec, H2L 4M1, Canada
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Montreal, Quebec, H3A 2B4, Canada
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Regina, Saskatchewan, S4S 3R8, Canada
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Brno, 656 91, Czechia
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Hradec Králové, 50333, Czechia
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Jihlava, 58633, Czechia
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Olomouc, 77520, Czechia
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Pardubice, 532 03, Czechia
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Prague, 100 34, Czechia
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Teplice, 41529, Czechia
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Aarhus C, 8200, Denmark
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Esbjerg, 6715, Denmark
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Glostrup Municipality, 2600, Denmark
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Odense C, 5000, Denmark
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Sønderborg, 6400, Denmark
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Montluçon, Allier, 03113, France
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Mulhouse, Haut Rhin, 68100, France
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Toulouse, Haute Garonne, 31059, France
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Pringy, Haute Savoie, 74374, France
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Rueil-Malmaison, Hauts De Seine, 92500, France
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Dax, Landes, 40107, France
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Agen, Lot Et Garonne, 47923, France
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Perpignan, Pyrenees Orientales, 66046, France
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Bron, Rhone, 69677, France
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La Roche-sur-Yon, Vendee, 85925, France
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Épinal, Vosges, 88021, France
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Gonesse, 95503, France
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Rambouillet, 78120, France
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Freiburg im Breisgau, Baden-Wurttemberg, 79098, Germany
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Heidelberg, Baden-Wurttemberg, 69120, Germany
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Heidenheim, Baden-Wurttemberg, 89518, Germany
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Ladenburg, Baden-Wurttemberg, 68526, Germany
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Mannheim, Baden-Wurttemberg, 68159, Germany
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Mannheim, Baden-Wurttemberg, 68161, Germany
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Ravensburg, Baden-Wurttemberg, 88212, Germany
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Singen, Baden-Wurttemberg, 78224, Germany
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Sinsheim, Baden-Wurttemberg, 74889, Germany
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Stuttgart, Baden-Wurttemberg, 70176, Germany
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Stuttgart, Baden-Wurttemberg, 70178, Germany
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Stuttgart, Baden-Wurttemberg, 70182, Germany
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Ulm, Baden-Wurttemberg, 89078, Germany
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Alzenau in Unterfranken, Bavaria, 63755, Germany
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Bayreuth, Bavaria, 95445, Germany
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Bogen, Bavaria, 94327, Germany
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Erlangen, Bavaria, 91054, Germany
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Landshut, Bavaria, 84028, Germany
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Munich, Bavaria, 81825, Germany
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Neuburg am Inn, Bavaria, 86633, Germany
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Nuremberg, Bavaria, 90419, Germany
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Nuremberg, Bavaria, 90451, Germany
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Regensburg, Bavaria, 93095, Germany
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Unterhaching, Bavaria, 82008, Germany
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Wolfratshausen, Bavaria, 82515, Germany
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Würzburg, Bavaria, 97080, Germany
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Butzbach, Hesse, 35510, Germany
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Eltville, Hesse, 65343, Germany
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Erbach im Odenwald, Hesse, 64711, Germany
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Eschwege, Hesse, 37269, Germany
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Frankfurt am Main, Hesse, 60313, Germany
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Frankfurt am Main, Hesse, 60488, Germany
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Frankfurt am Main, Hesse, 60528, Germany
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Gelnhausen, Hesse, 63571, Germany
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Giessen, Hesse, 35392, Germany
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Gladenbach, Hesse, 35075, Germany
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Kassel, Hesse, 34121, Germany
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Wiesbaden, Hesse, 65183, Germany
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Buchholz, Lower Saxony, 21244, Germany
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Göttingen, Lower Saxony, 37073, Germany
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Oldenburg, Lower Saxony, 26122, Germany
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Stade, Lower Saxony, 21682, Germany
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Aachen, North Rhine-Westphalia, 52062, Germany
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Aachen, North Rhine-Westphalia, 52078, Germany
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Bad Honnef, North Rhine-Westphalia, 53604, Germany
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Bergisch Gladbach, North Rhine-Westphalia, 51429, Germany
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Bielefeld, North Rhine-Westphalia, 33647, Germany
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Bochum, North Rhine-Westphalia, 44789, Germany
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Bonn, North Rhine-Westphalia, 53111, Germany
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Cologne, North Rhine-Westphalia, 50935, Germany
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Cologne, North Rhine-Westphalia, 51063, Germany
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Düsseldorf, North Rhine-Westphalia, 40211, Germany
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Essen, North Rhine-Westphalia, 45138, Germany
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Hagen, North Rhine-Westphalia, 58095, Germany
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Remscheid, North Rhine-Westphalia, 42853, Germany
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Siegen, North Rhine-Westphalia, 57076, Germany
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Willich, North Rhine-Westphalia, 47877, Germany
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Wuppertal, North Rhine-Westphalia, 42284, Germany
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Frankenthal, Rhineland-Palatinate, 67227, Germany
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Kandel, Rhineland-Palatinate, 76870, Germany
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Katzenelnbogen, Rhineland-Palatinate, 56368, Germany
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Rülzheim, Rhineland-Palatinate, 76761, Germany
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Trier, Rhineland-Palatinate, 54292, Germany
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Chemnitz, Saxony, 09117, Germany
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Görlitz, Saxony, 02828, Germany
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Leipzig, Saxony, 04103, Germany
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Leipzig, Saxony, 04229, Germany
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Wermsdorf, Saxony, 04779, Germany
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Halle, Saxony-Anhalt, 06120, Germany
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Magdeburg, Saxony-Anhalt, 39120, Germany
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Kiel, Schleswig-Holstein, 24105, Germany
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Eisenach, Thuringia, 99817, Germany
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Erfurt, Thuringia, 99096, Germany
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Jena, Thuringia, 07747, Germany
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Berlin, 10713, Germany
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Berlin, 10961, Germany
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Berlin, 12099, Germany
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Berlin, 12163, Germany
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Berlin, 13347, Germany
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Berlin, 13465, Germany
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Hamburg, 20249, Germany
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Hamburg, 21149, Germany
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Neusäß, 86356, Germany
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Budapest, 1086, Hungary
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Budapest, 1106, Hungary
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Budapest, 1145, Hungary
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Eger, 3300, Hungary
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Győr, 9024, Hungary
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Miskolc, 3526, Hungary
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Szeged, 6725, Hungary
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Tatabánya, 2800, Hungary
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Zalaegerszeg, 8900, Hungary
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Dublin, D04 N2E0, Ireland
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Dublin, D09 V2N0, Ireland
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Torrette, Ancona, 60126, Italy
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Montichiari, Brescia, 25018, Italy
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Pozzilli, Isernia, 86077, Italy
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Legnano, Milano, 20025, Italy
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Fidenza, Parma, 43036, Italy
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Orbassano, Torino, 10043, Italy
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Gallarate, Varese, 21013, Italy
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Bari, 70124, Italy
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Bergamo, 24127, Italy
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Bologna, 40139, Italy
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Cagliari, 09126, Italy
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Catanzaro, 88100, Italy
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Genova, 16132, Italy
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Messina, 98125, Italy
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Milan, 20132, Italy
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Modena, 41126, Italy
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Napoli, 80131, Italy
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Palermo, 90127, Italy
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Palermo, 90146, Italy
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Parma, 43126, Italy
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Pavia, 27100, Italy
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Perugia, 06156, Italy
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Pordenone, 33170, Italy
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Reggio Emilia, 42100, Italy
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Roma, 00152, Italy
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Roma, 00161, Italy
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Roma, 00168, Italy
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Roma, 00189, Italy
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Amsterdam, 1091 AC, Netherlands
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Arnhem, 6815 AD, Netherlands
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Breda, 4818 CK, Netherlands
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Eindhoven, 5623 EJ, Netherlands
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Geldrop, 5664 EH, Netherlands
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Geleen, 6162 BG, Netherlands
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Hoorn, 1624 NP, Netherlands
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Leeuwarden, 8934 AD, Netherlands
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Leiden, 2334 CK, Netherlands
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Nieuwegein, 3435 CM, Netherlands
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Nijmegen, 6532 SZ, Netherlands
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Tilburg, 5042 AD, Netherlands
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Venlo, 5912 BL, Netherlands
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Christchurch, 8011, New Zealand
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Dunedin, 9016, New Zealand
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Hamilton, 3200, New Zealand
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Bodø, 8005, Norway
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Namsos, 7801, Norway
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Ochojec, Katowice, 40-635, Poland
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Bialystok, 15-276, Poland
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Bydgoszcz, 85-681, Poland
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Gdansk, 80-803, Poland
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Gmina Końskie, 26-200, Poland
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Grudziądz, 86-300, Poland
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Głogów Małopolski, 36-060, Poland
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Katowice, 40-571, Poland
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Katowice, 40-752, Poland
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Konstancin-Jeziorna, 05-510, Poland
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Krakow, 31-503, Poland
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Krakow, 31-637, Poland
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Lublin, 20-954, Poland
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Olsztyn, 10-561, Poland
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Poznan, 60-355, Poland
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Warsaw, 02-091, Poland
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Warsaw, 02-957, Poland
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Warsaw, 04-749, Poland
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Zabrze, 41-800, Poland
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Amadora, 2720-276, Portugal
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Braga, 4710-243, Portugal
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Guimarães, 4835-044, Portugal
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Matosinhos Municipality, 4454-509, Portugal
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Penafiel, 4560-007, Portugal
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Santarém, 2005-177, Portugal
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Viana do Castelo, 4901-858, Portugal
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Vila Nova de Gaia, 4434-502, Portugal
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Guaynabo, 00968, Puerto Rico
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San Juan, 00921, Puerto Rico
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Banská Bystrica, 97517, Slovakia
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Bratislava, 82101, Slovakia
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Bratislava, 83101, Slovakia
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Martin, 03659, Slovakia
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Nitra, 95001, Slovakia
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Prešov, 08081, Slovakia
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Ružomberok, 03426, Slovakia
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Trenčín, 91101, Slovakia
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Trnava, 917 75, Slovakia
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Palma de Mallorca, Balearic Islands, 07010, Spain
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Badalona, Barcelona, 08916, Spain
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L'Hospitalet de Llobregat, Barcelona, 08907, Spain
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Santander, Cantabria, 38003, Spain
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Santiago de Compostela, La Coruña, 15706, Spain
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Gijón, Principality of Asturias, 33206, Spain
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Santa Cruz de Tenerife, Tenerife, 38010, Spain
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Alzira, Valencia, 46600, Spain
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Ávila, 05004, Spain
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Cadiz, 11009, Spain
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Granada, 18014, Spain
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Huelva, 21080, Spain
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Jaén, 23007, Spain
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Madrid, 28006, Spain
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Murcia, 30008, Spain
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Pontevedra, 36071, Spain
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Bern, 3010, Switzerland
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Lausanne, CH-1011, Switzerland
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Lugano, 6900, Switzerland
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Bristol, Avon, BS10 5NB, United Kingdom
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Exeter, Devon, EX2 5DW, United Kingdom
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Plymouth, Devon, PL6 8DH, United Kingdom
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Torquay, Devon, TQ2 7AA, United Kingdom
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Salford, Greater Manchester, M6 8HD, United Kingdom
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Basingstoke, Hampshire, RG24 9NA, United Kingdom
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Southampton, Hampshire, SO16 6YD, United Kingdom
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Leicester, Leicestershire, LE5 4PW, United Kingdom
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Edinburgh, Lothian Region, EH4 2XU, United Kingdom
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Liverpool, Merseyside, L9 7LJ, United Kingdom
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Norwich, Norfolk, NR4 7UY, United Kingdom
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Nottingham, Nottinghamshire, NG7 2UH, United Kingdom
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Glasgow, Strathclyde, G51 4TF, United Kingdom
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Dundee, Tayside Region, DD1 9SY, United Kingdom
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Newcastle upon Tyne, Tyne & Wear, NE4 5PL, United Kingdom
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Birmingham, West Midlands, B15 2GB, United Kingdom
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Leeds, West Yorkshire, LS1 3EX, United Kingdom
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Belfast, BT16 0RH, United Kingdom
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Swansea, SA6 6NL, United Kingdom
Related Publications (3)
Pandey KS, Giles K, Balashov K, Macdonell R, Windsheimer J, Martinez M, Bozin I, Raynaud S, Scaramozza M, Mokliatchouk O, Sun Z, Belviso N, Sato Y, Lin X, Okai A. Long-Term Safety and Effectiveness of Dimethyl Fumarate in Patients with Multiple Sclerosis Treated in Routine Medical Practice: Final Analysis of the ESTEEM Study. Neurol Ther. 2025 Feb;14(1):243-260. doi: 10.1007/s40120-024-00680-z. Epub 2024 Dec 14.
PMID: 39673658DERIVEDMao-Draayer Y, Bar-Or A, Balashov K, Foley J, Smoot K, Longbrake EE, Robertson D, Mendoza JP, Lewin JB, Everage N, Bozin I, Lyons J, Mokliatchouk O, Bame E, Giuliani F. Real-World Safety and Effectiveness of Dimethyl Fumarate in Patients with MS: Results from the ESTEEM Phase 4 and PROCLAIM Phase 3 Studies with a Focus on Older Patients. Adv Ther. 2025 Jan;42(1):395-412. doi: 10.1007/s12325-024-03047-w. Epub 2024 Nov 21.
PMID: 39570545DERIVEDWilliams MJ, Amezcua L, Chinea A, Cohan S, Okai A, Okuda DT, Vargas W, Belviso N, Bozin I, Jiang X, Lewin JB, Lyons J, Shen C, England SM, Grimes N. Real-World Safety and Effectiveness After 5 Years of Dimethyl Fumarate Treatment in Black and Hispanic Patients with Multiple Sclerosis in ESTEEM. Neurol Ther. 2023 Oct;12(5):1669-1682. doi: 10.1007/s40120-023-00517-1. Epub 2023 Jun 24.
PMID: 37354276DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Medical Director
Biogen
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Target Duration
- 5 Years
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
January 24, 2014
First Posted
January 28, 2014
Study Start
November 19, 2013
Primary Completion
October 31, 2022
Study Completion
October 31, 2022
Last Updated
May 24, 2023
Record last verified: 2023-05