Reward System Responses to Food Aromas
1 other identifier
observational
332
1 country
1
Brief Summary
Food aromas are a part of foods' flavor, and can promote overeating. Alcohol consumption also stimulates appetite, and contributes to overeating while under alcohol's acute effects. Knowing the brain regions that respond to food aromas and alcohol, and how they are modified by the amount of body fat and alcohol exposure, will provide critical information about the neural systems that underlie loss of control of eating. Therefore, the main hypotheses of this study are that: A) Lean and obese subjects have different brain responses to food aromas that enhance desire to eat, and B) Acute alcohol intoxication i) enhances the brain's response to food odors, and ii) affects brain systems that inhibit or terminate eating. To test these hypotheses, we have modified functional magnetic resonance imaging (fMRI) paradigms successfully used to study alcoholic drink aromas in subjects at risk for alcoholism.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Apr 2011
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
April 15, 2011
CompletedFirst Submitted
Initial submission to the registry
January 17, 2014
CompletedFirst Posted
Study publicly available on registry
January 20, 2014
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 11, 2015
CompletedStudy Completion
Last participant's last visit for all outcomes
September 11, 2015
CompletedJuly 11, 2024
July 1, 2024
4.4 years
January 17, 2014
July 9, 2024
Conditions
Outcome Measures
Primary Outcomes (1)
neural response to food odor
1 month
Study Arms (2)
normal weight
non-smoking, right handed women age 18-40 years BMI between 18-25 kg/m2
overweight/obese
non-smoking, right-handed women age 18-40 year BMI 30-50 kg/m2 (maximum weight 350 pounds, shoulder width no greater than 23/5 inches)
Eligibility Criteria
subjects to be drawn from the Indianapolis and greater metropolitan area
You may qualify if:
- non smoking, right handed women 18-40 years
- good health without self reported neurological or psychiatric disorder
- no indication of eating disorders
- normal sense of smell
You may not qualify if:
- pregnant,/breast feeding women
- history of drug abuse/dependence, positive drug screen for amphetamines/methamphetamines, barbiturates, benzodiazepines, cannabinoids, cocaine, opiates or PCP
- DSM-IV axis I psychiatric disorders or head injury with loss of consciousness
- contraindications to MRI (ferrous material, claustrophobia)
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Indiana University School of Medicine
Indianapolis, Indiana, 46202, United States
Related Publications (1)
Eiler WJ 2nd, Dzemidzic M, Case KR, Armstrong CL, Mattes RD, Cyders MA, Considine RV, Kareken DA. Ventral frontal satiation-mediated responses to food aromas in obese and normal-weight women. Am J Clin Nutr. 2014 Jun;99(6):1309-18. doi: 10.3945/ajcn.113.080788. Epub 2014 Apr 2.
PMID: 24695888DERIVED
Biospecimen
serum/plasma
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR INVESTIGATOR
- PI Title
- Professor of Medicine
Study Record Dates
First Submitted
January 17, 2014
First Posted
January 20, 2014
Study Start
April 15, 2011
Primary Completion
September 11, 2015
Study Completion
September 11, 2015
Last Updated
July 11, 2024
Record last verified: 2024-07