Pre-meal Planning and Expected Satiety

NCT02427152 | Unknown

• 1 other identifier: Satt
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Obesity is considered to be caused by an imbalance between energy expenditure and energy intake. A major determinant of our daily energy intake is the size of the meals that we consume. It has been suggested that decisions about portion sizes are often made in advance, before a meal begins. This pre-meal planning is considered to especially depend on the estimated 'expected satiety' and 'expected satiation' of different foods. Further, also factors like weight concern and palatability of the food might have their influence on meal size selection. In general, it is not clear how these factors are integrated during pre-meal planning and which brain networks are involved in these decisions/this process. Thus, the investigators plan to study pre-meal planning in healthy, normal-weight and overweight/obese individuals with functional magnetic resonance imaging under different cognitive instructions including pleasure, expected satiety and self-control in terms of health consequences. The investigators will explore the neural networks involved in pre-meal planning and expect them to be modulated by the before mentioned factors. Further, the investigators plan to explore gender differences and expect that female subjects will select smaller portion sizes especially in the self-control condition as they are often more concerned about their weight/health. Finally, the investigators will explore differences between lean and overweight subjects to elucidate factors that might lead to increased meal sizes in overweight subjects.

Conditions

Adiposity

Outcome Measures

Primary Outcomes (1)

• Differential brain functions in reward, decision making and inhibitory control networks (brain functions will be measured by blood oxygen level dependent effects)

  brain functions will be measured by blood oxygen level dependent effects

  day 0

Secondary Outcomes (1)

• Differential behavioral measures of portion size selection

  day 0

Study Arms (2)

Lean

body mass index: 18-25 kg/m²

Overweight/Obese

body mass index: \>25 kg/m²

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

lean and overweight/obese healthy volunteers

You may qualify if:

• body mass index: 18-25 kg/m²; 25-35 kg/m²,
• right-handed,
• age: 18-35 years.

You may not qualify if:

• functional magnetic resonance imaging contraindications,
• claustrophobia,
• self-reported eating disorders,
• vegan or vegetarian diet, food allergies,
• intake of antidepressants,
• metabolic disorders.

Sponsors & Collaborators

• University Hospital Tuebingen: lead

Study Sites (1)

University Clinic of Tuebingen, fMEG Center

Tübingen, 72076, Germany

RECRUITING

MeSH Terms

Conditions

Obesity

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Hege

CONTACT

maike.hege@med.uni-tuebingen.de

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 18, 2015
• First Posted: April 27, 2015
• Study Start: March 1, 2015
• Primary Completion: December 1, 2017
• Study Completion: December 1, 2017
• Last Updated: May 31, 2017

Record last verified: 2017-05

Locations

DE (1)