Comparing the Effects of Exercise on the Structure and Function of Fat Tissue
CAT
Effects of Exercise Training on the Structure and Metabolic Function of Fat Tissue
1 other identifier
interventional
45
1 country
1
Brief Summary
Assess differences in structure and biological function of abdominal subcutaneous adipose tissue samples collected from adults who exercise regularly vs. a well-matched cohort of non-exercisers.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Jun 2020
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
June 4, 2020
CompletedFirst Submitted
Initial submission to the registry
April 7, 2022
CompletedFirst Posted
Study publicly available on registry
April 14, 2022
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 3, 2023
CompletedStudy Completion
Last participant's last visit for all outcomes
December 9, 2024
CompletedJune 29, 2025
June 1, 2025
3.2 years
April 7, 2022
June 25, 2025
Conditions
Outcome Measures
Primary Outcomes (2)
Blood Glucose Level
mg/dL
2 hours at Experimental Trial
Adipose tissue fibrosis
Pico-sirius Red stain (percent stained)
baseline
Study Arms (1)
Oral Glucose Tolerance Test
EXPERIMENTALSubjects will complete an Oral Glucose Tolerance Test in which glucose is given and blood samples are taken every 15 minutes over a 2 hour period to determine how quickly the glucose is cleared from the blood.
Interventions
Subjects will complete an Oral Glucose Tolerance Test in which glucose is given and blood samples are taken every 15 minutes over a 2 hour period to determine how quickly the glucose is cleared from the blood.
Eligibility Criteria
You may qualify if:
- Age: 18-40 years old
- Body Mass Index: 23-35 kg/m2
- Women must have regularly occurring menses and must be premenopausal
You may not qualify if:
- Evidence/history of cardiovascular or metabolic disease
- Medications known to affect lipid or glucose metabolism, or inflammation
- Weight instability ≥ ± 6 pounds in the last 6 months
- Tobacco or e-cigarette users
- Women must not be pregnant or actively lactating
- Blood pressure \> 140/90 mmHg
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
University of Michigan
Ann Arbor, Michigan, 48109, United States
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Jeffrey F Horowitz, PhD
University of Michigan
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor of Movement Science and Director of the Substrate Metabolism Laboratory (SML) at the University of Michigan School of Kinesiology
Study Record Dates
First Submitted
April 7, 2022
First Posted
April 14, 2022
Study Start
June 4, 2020
Primary Completion
August 3, 2023
Study Completion
December 9, 2024
Last Updated
June 29, 2025
Record last verified: 2025-06
Data Sharing
- IPD Sharing
- Will not share