A Study of the Efficacy and Safety of MetMAb Combined With Tarceva in Patients With Met-Positive Non-Small Cell Lung Cancer

NCT02031744 | Completed Phase 3

• 1 other identifier: YO28345
• Study Type: interventional
• Target: 530
• Locations: 1 country
• Sites: 8

Brief Summary

This randomized, Phase III, double-blind, placebo-controlled study will evaluate the safety and efficacy of MetMAb (onartuzumab) in combination with Tarceva (erlotinib) compared with treatment with Tarceva alone in patients with incurable Met-positive non-small cell lung cancer (NSCLC). Patients will be randomized in a 2:1 ratio to receive either MetMAb + Tarceva or placebo + Tarceva. Tarceva (150 mg) will be given orally once daily, and MetMAb (15 mg/kg) will be given intravenously every 3 weeks. Treatment will continue until disease progression, unacceptable toxicity, a decision to discontinue, or death occurs. Total study length is expected to be around 36 months.

Conditions

Non-Small Cell Lung Cancer

Outcome Measures

Primary Outcomes (2)

• Overall survival (OS)

  Up to 36 months

• Incidence of adverse events

  Up to 33 months

Secondary Outcomes (4)

• Progression-free survival (PFS), defined as time from randomization until progression as measured by the Response Evaluation Criteria in Solid Tumors (RECIST) v1.1 or death.

  Up to 36 months

• Overall response rate (ORR), as measured by RECIST v1.1

  Up to 36 months

• Health-related quality of life (HRQOL) as measured by the European Organization for the Research and Treatment of Cancer (EORTC) assessments

  Up to 33 months

• Incidence of anti-therapeutic antibodies against MetMAB

  Up to 33 months

Study Arms (2)

erlotinib [Tarceva] + placebo

PLACEBO COMPARATOR

Drug: erlotinib [Tarceva]; Drug: Placebo

erlotinib [Tarceva] + onartuzumab [MetMAb]

EXPERIMENTAL

Drug: erlotinib [Tarceva]; Drug: Onartuzumab [MetMAb]

Interventions

erlotinib [Tarceva] DRUG

150 mg oral administration once daily

erlotinib [Tarceva] + onartuzumab [MetMAb]; erlotinib [Tarceva] + placebo

Placebo DRUG

15 mg/kg intravenous administration every 3 weeks

erlotinib [Tarceva] + placebo

Onartuzumab [MetMAb] DRUG

15 mg/kg intravenous administration every 3 weeks

erlotinib [Tarceva] + onartuzumab [MetMAb]

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Male or female, 18 years or older.
• Patients with an Eastern Cooperative Oncology Group (ECOG) performance status of 0-1.
• Histologically confirmed incurable Stage IIIB/IV NSCLC tumor.
• Met-positive status and results of epidermal growth factor receptor (EGFR)-activating mutation testing.
• Available tumor tissue sample or agreement to take such a sample.
• Radiographic evidence of disease. Lesions must be outside a previous radiotherapy field if they are the sole site of disease, unless disease progression has occurred at that site since radiation.
• Prior treatment with at least one platinum-based line of treatment for locally advanced, unresectable/inoperable disease or metastatic disease, and no more than one additional line of chemotherapy treatment, defined as follows:
• Adjuvant/neoadjuvant chemotherapy or chemoradiation counts as a line of therapy if \< 12 months have elapsed between the last dose and the date of recurrence. Combined treatment with chemotherapy and radiation constitutes a single regimen; surgery is not considered a regimen.
• Cytotoxic maintenance therapy that differs from first-line therapy is considered an additional line of therapy. However, changes in treatment due to intolerance or excessive toxicity are not considered an additional regimen.
• The last dose of prior chemotherapy must have been given \>/= 21 days prior to Day 1 (\>/= 14 days for vinorelbine or other vinca alkaloids or gemcitabine).
• Anti-cancer agents used for pleurodesis are not counted as a line of therapy.
• Prior radiation therapy is allowed provided the patient has recovered from any toxic effects and \>/= 7 days have elapsed between the last session and randomization.
• Patients must use effective contraception throughout the trial and until 3 months after the last dose.

You may not qualify if:

• More than 30 days expsoure to an EGFR inhibitor or a known EGFR-toxicity resulting in dose modifications.
• Prior exposure to agents targeting either the HGF or MET pathway, including but not limited to crizotinib, cabozantinib, ficlatuzumab, rilotumumab, and tivantinib.
• Pleural effusion, pericardial fluid, or ascites requiring drainage every other week or more frequently.
• Brain metastases or spinal cord compression that were not definitively treated with surgery and/or radiation or that were previously diagnosed and treated without evidence of clinically stable disease for \>/= 14 days. Patients with treated central nervous system (CNS) metastases who are asymptomatic and on a stable dose of corticosteroid for \>/= 14 days prior to randomization are eligible.
• History of another cancer in the previous 5 years, except for appropriately treated carcinoma in situ of the cervix, non-melanoma skin cancer, stage I uterine cancer, or other cancers that are curable.
• Life expectancy \< 12 weeks.
• Radiographically visible interstitial lung disease (ILD) or a history of it. History of radiation pneumonitis in the radiation field (fibrosis) is permitted.
• Inadequate hematologic, biological, or organ function.
• Significant history of cardiac disease.
• Serious active infection at the time of randomization or other serious underlying medical conditions that would impair the ability of the patient to receive protocol treatment, including positive HIV or active hepatitis B or C infections, significant gastrointestinal abnormalities, uncontrolled diabetes.
• Any inflammatory changes to the surface of the eye.
• Inability to take oral medication, need for intravenous alimentation, prior surgical procedures affecting absorption, or active peptic ulcer disease.
• Pregnant or breast-feeding women.
• Any major surgery within 2 weeks prior to randomization.
• Inability to understand the language(s) in which the HRQOL questionnaires are available.

Sponsors & Collaborators

• Hoffmann-La Roche: lead

Study Sites (8)

The Affiliated Hospital of Military Medical Sciences(The 307th Hospital of Chinese PLA)

Beijing, 100071, China

Location

Jilin Cancer Hospital

Changchun, 130012, China

Location

Southwest Hospital , Third Military Medical University

Chongqing, 400038, China

Location

Third Affiliated Hospital of Third Military Medical University

Chongqing, 400042, China

Location

Sun Yet-sen University Cancer Center

Guangzhou, 510060, China

Location

Zhejiang Cancer Hospital

Hangzhou, 310022, China

Location

Harbin Medical University Cancer Hospital

Harbin, 150081, China

Location

Jiangsu Cancer Hospital

Nanjing, 210009, China

Location

MeSH Terms

Conditions

Carcinoma, Non-Small-Cell Lung

Interventions

Erlotinib Hydrochloride; onartuzumab

Condition Hierarchy (Ancestors)

Carcinoma, Bronchogenic; Bronchial Neoplasms; Lung Neoplasms; Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms; Lung Diseases; Respiratory Tract Diseases

Intervention Hierarchy (Ancestors)

Quinazolines; Heterocyclic Compounds, 2-Ring; Heterocyclic Compounds, Fused-Ring; Heterocyclic Compounds

Study Officials

• Clinical Trials

  Hoffmann-La Roche

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: phase 3
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 8, 2014
• First Posted: January 9, 2014
• Study Start: January 22, 2014
• Primary Completion: January 6, 2016
• Study Completion: January 6, 2016
• Last Updated: March 14, 2017

Record last verified: 2017-03

Locations

CN (8)