The Effect of Juice Types on the Responses to Air Pollution

NCT02027415 | Completed

• 1 other identifier: Pro2013003273
• Study Type: interventional
• Target: 24
• Locations: 1 country
• Sites: 1

Brief Summary

The study hypothesis is that drinking different juices will affect the body's responses to air pollution. Subjects will be exposed to air pollution during a 2-hour car ride on the NJ (New Jersey) Turnpike. Each subject will be asked to do this twice. Before one car ride, the subject will be asked to drink orange juice. Before the other car ride, the subject will be asked to drink beet juice. Samples of blood and exhaled breath will be collected before, immediately after, and 24 hours after each car ride. Levels of nitrites/nitrates will be measured in the blood and breath.

Conditions

Air Pollution

Keywords

air pollution; food; nitrites; nitrates; breath tests/methods

Outcome Measures

Primary Outcomes (1)

• Change in plasma nitrite concentration

  Change in plasma nitrite concentration pre- and post-occlusion

  Prior to the car ride, immediately after the 2-hour car ride, and 24 hours later

Secondary Outcomes (1)

• Change in nitrite/nitrate concentration in exhaled breath

  Prior to the car ride, immediately after the 2 hour car ride and 24 hours later

Study Arms (2)

Beet Orange

EXPERIMENTAL

Beet juice will be given prior to the first car ride and orange juice will be given prior to the second car ride.

Dietary Supplement: Beet juice; Dietary Supplement: Orange juice

Orange Beet

EXPERIMENTAL

Orange juice will be given before the first car ride and beet juice will be given before the second car ride.

Dietary Supplement: Beet juice; Dietary Supplement: Orange juice

Interventions

Beet juice DIETARY_SUPPLEMENT

2 cups of beet juice will be given before the car ride

Beet Orange; Orange Beet

Orange juice DIETARY_SUPPLEMENT

2 cups of orange juice will be given before the car ride

Beet Orange; Orange Beet

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy
• Must live within 20 miles of Piscataway, NJ

You may not qualify if:

• Are a current smoker
• Are pregnant or breastfeeding
• Are HIV-positive
• Have an active medical condition such as high blood pressure, asthma, diabetes or other serious disease
• Have a heart condition such as atrial flutter, atrial fibrillation or a pacemaker
• Are unable to ride comfortably in a car for 2 hours
• Travel to the EOHSI (Environmental and Occupational Health Sciences Institute) Clinic Center on major highways for more than 3 miles (the Garden State Parkway, the New Jersey Turnpike, Routes 287, 1, 18, or 9).

Sponsors & Collaborators

• Rutgers, The State University of New Jersey: lead

Study Sites (1)

Environmental and Occupational Health Sciences Institute

Piscataway, New Jersey, 08854, United States

Location

Related Publications (3)

• Laumbach RJ, Rich DQ, Gandhi S, Amorosa L, Schneider S, Zhang J, Ohman-Strickland P, Gong J, Lelyanov O, Kipen HM. Acute changes in heart rate variability in subjects with diabetes following a highway traffic exposure. J Occup Environ Med. 2010 Mar;52(3):324-31. doi: 10.1097/JOM.0b013e3181d241fa.

  PMID: 20190650 BACKGROUND

• Hussain S, Laumbach R, Coleman J, Youssef H, Kelly-McNeil K, Ohman-Strickland P, Zhang J, Kipen H. Controlled exposure to diesel exhaust causes increased nitrite in exhaled breath condensate among subjects with asthma. J Occup Environ Med. 2012 Oct;54(10):1186-91. doi: 10.1097/JOM.0b013e31826bb64c.

  PMID: 23001278 BACKGROUND

• Laumbach RJ, Kipen HM. Acute effects of motor vehicle traffic-related air pollution exposures on measures of oxidative stress in human airways. Ann N Y Acad Sci. 2010 Aug;1203:107-12. doi: 10.1111/j.1749-6632.2010.05604.x.

  PMID: 20716291 BACKGROUND

Study Officials

• Howard Kipen, MD

  Rutgers RWJMS

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor and Department Chair

Study Record Dates

• First Submitted: December 16, 2013
• First Posted: January 6, 2014
• Study Start: December 1, 2013
• Primary Completion: October 1, 2014
• Study Completion: October 1, 2014
• Last Updated: December 13, 2017

Record last verified: 2017-12

Locations

US (1)