Boston Puerto Rican Health Study

NCT03187704 | Completed

• 1 other identifier: BPRHS-Project4
• Study Type: interventional
• Target: 23
• Locations: 1 country
• Sites: 1

Brief Summary

The study is a blinded cross over test of in-home air filtration. Participants will have a window unit air filter (HEPA) installed that will filter for 3 weeks and do sham filtration for another 3 weeks. During the time that the filter is installed in the home a machine that measures particulate air pollution of the type that the filter is designed to remove will be installed. A survey will be administered, blood samples taken and blood pressure measured immediately prior to starting the filter, at 3 weeks when the filtration is changed from sham to real filtration or visa versa and at the end of the second three week period. All participants will be recruited from the Boston Puerto Rican Health Study cohort.

Conditions

Air Pollution; Cardiovascular Health

Keywords

air filtration, HEPA, In-home,

Outcome Measures

Primary Outcomes (1)

• Blood biomarkers

  hsCRP, IL-6, TNFRII

  6 weeks

Study Arms (2)

filtration

ACTIVE COMPARATOR

Air filtration in homes

Other: HEPA air filtration

no filtration

SHAM COMPARATOR

Sham air filtration

Other: HEPA air filtration

Interventions

HEPA air filtration OTHER

Air filters were placed in participant homes

filtration; no filtration

Eligibility Criteria

• Age: 45 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Participant in the larger parent cohort of the BPRHS

You may not qualify if:

• None since already enrolled in the cohort

Sponsors & Collaborators

• Tufts University: lead

Study Sites (1)

Tufts University School of Medicine

Boston, Massachusetts, 02111, United States

Location

Related Publications (5)

• Padro-Martinez LT, Owusu E, Reisner E, Zamore W, Simon MC, Mwamburi M, Brown CA, Chung M, Brugge D, Durant JL. A Randomized Cross-over Air Filtration Intervention Trial for Reducing Cardiovascular Health Risks in Residents of Public Housing near a Highway. Int J Environ Res Public Health. 2015 Jul 10;12(7):7814-38. doi: 10.3390/ijerph120707814.

  PMID: 26184257 BACKGROUND

• Bhangar S, Mullen NA, Hering SV, Kreisberg NM, Nazaroff WW. Ultrafine particle concentrations and exposures in seven residences in northern California. Indoor Air. 2011 Apr;21(2):132-44. doi: 10.1111/j.1600-0668.2010.00689.x. Epub 2010 Oct 28.

  PMID: 21029183 BACKGROUND

• Rim D, Wallace L, Persily A. Infiltration of outdoor ultrafine particles into a test house. Environ Sci Technol. 2010 Aug 1;44(15):5908-13. doi: 10.1021/es101202a.

  PMID: 20666560 BACKGROUND

• Wallace L, Kindzierski W, Kearney J, MacNeill M, Heroux ME, Wheeler AJ. Fine and ultrafine particle decay rates in multiple homes. Environ Sci Technol. 2013 Nov 19;47(22):12929-37. doi: 10.1021/es402580t. Epub 2013 Nov 6.

  PMID: 24143863 BACKGROUND

• Beko G, Weschler CJ, Wierzbicka A, Karottki DG, Toftum J, Loft S, Clausen G. Ultrafine particles: exposure and source apportionment in 56 Danish homes. Environ Sci Technol. 2013 Sep 17;47(18):10240-8. doi: 10.1021/es402429h. Epub 2013 Sep 4.

  PMID: 23957328 BACKGROUND

Study Officials

• Doug Brugge, PhD

  Tufts University

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Masking Details: Participants were blinded as to filtration and no filtration. The lab was blinded as to which samples were from filtration or no filtration periods.
• Purpose: PREVENTION
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Model Details: Randomized cross-over

Study Record Dates

• First Submitted: June 13, 2017
• First Posted: June 15, 2017
• Study Start: May 1, 2012
• Primary Completion: December 31, 2014
• Study Completion: December 31, 2014
• Last Updated: June 20, 2017

Record last verified: 2017-06

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)