Reducing Traffic Pollution Exposure Improves Blood Pressure

NCT04029129 | Completed Results

• 2 other identifiers: 19X-183=1R01ES026980
• Study Type: interventional
• Target: 77
• Locations: 1 country
• Sites: 1

Brief Summary

This randomized trial assessed the effect of modifying building envelop and level of air filtration on blood pressure over two hour exposure sessions.

Conditions

Air Pollution

Keywords

Traffic-related air pollution; Air filtration; Blood pressure; Controlled exposure

Outcome Measures

Primary Outcomes (1)

• Systolic Blood Pressure (SBP)

  Systolic blood pressure measured with ambulatory blood pressure monitors in mmHg.

  Over 2 hour exposure period, we measured SBP after 20 minutes with the objective to assess change in SBP in a time series of measurements over that time period.

Secondary Outcomes (1)

• Diastolic Blood Pressure (DBP)

  Over a 2 hour exposure period with the objective to assess change in DBP measured after 10 minutes in a time series of measurements over that time period.

Study Arms (3)

High exposure

EXPERIMENTAL

Ambient air was allowed freely into the room.

Other: Air filtration and building envelop modifications

Medium exposure

EXPERIMENTAL

Limited air filtration was used to partially reduce levels of pollution in the room relative to outside.

Other: Air filtration and building envelop modifications

Low exposure

EXPERIMENTAL

Doors and windows were closed and sealed and full filtration was used to maximally reduce pollution in the room.

Other: Air filtration and building envelop modifications

Interventions

Air filtration and building envelop modifications OTHER

Air filters and closing and sealing of windows and doors was used to reduce infiltration of air pollution from outdoors in rooms next to major highways at rush hour.

High exposure; Low exposure; Medium exposure

Eligibility Criteria

• Age: 40 Years - 75 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• There was a preference for people who were otherwise healthy, but overweight or obese.

You may not qualify if:

• A history of a major cardiovascular outcome (including myocardial ischemia (MI), stroke, angina)
• Other serious health problems (current asthma or COPD)
• Taking anti-hypertensive medications
• Smoking or living with a smoker
• Cognitive impairment
• Working at a job with high combustion exposure (taxi/truck driver, restaurant cook)
• High combustion exposure in the preceding 24 hours (driving on the highway, cooking in a restaurant, driving a truck)
• Not speaking English or Chinese.

Sponsors & Collaborators

• UConn Health: lead
• National Institute of Environmental Health Sciences (NIEHS): collaborator

Study Sites (1)

University of Connecticut

Farmington, Connecticut, 06030, United States

Location

Results Point of Contact

• Title: Dr. Douglas Brugge
• Organization: UConnHealth

brugge@uchc.edu

860-679-8814

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Masking Details: Participants were not told the high, medium and low exposure context, however, some aspects of the sessions might have been apparent to them since filters were running during high, but not low exposure sessions.
• Purpose: OTHER
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor and Chair

Model Details: Randomized cross over trial

Study Record Dates

• First Submitted: July 16, 2019
• First Posted: July 23, 2019
• Study Start: March 1, 2018
• Primary Completion: June 15, 2018
• Study Completion: June 15, 2018
• Last Updated: September 28, 2023
• Results First Posted: September 28, 2023

Record last verified: 2023-09

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)