Metabolic Responses to Bariatric Surgery
Genetic and Biochemical Characteristics of Medically-Complicated Obesity and Response to Bariatric Surgery
1 other identifier
observational
500
1 country
1
Brief Summary
Research the genetic and biomechanical markers of human adipose tissue on patients with morbid obesity. Additional tissue/fluid collection is also gathered during the time of surgery.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Feb 2011
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
February 1, 2011
CompletedFirst Submitted
Initial submission to the registry
December 25, 2013
CompletedFirst Posted
Study publicly available on registry
December 31, 2013
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 1, 2035
ExpectedStudy Completion
Last participant's last visit for all outcomes
April 1, 2035
May 18, 2026
May 1, 2026
24.2 years
December 25, 2013
May 14, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Tensile Strength of White Adipose Tissue
During the research tissue samples were compared between healthy obese patients (no diabetes, controlled HTN, no dyslipidemia) with tissue samples collected on non-healthy obese patients (type II diabetes) and using fat collected from mice as a control.
July 2012
Study Arms (2)
Weight Loss Surgery - Healthy
Patients consented to participate have met the NIH criteria for Bariatric Surgery and have completed the normal pre-operative work up including nutritional counseling, psychological evaluation, and all necessary studies to rule out other co-morbid conditions prior to surgery. Patients do not have metabolic syndrome.
Weight Loss Surgery - Metabolic Syndrome
Patients consented to participate have met the NIH criteria for Bariatric Surgery and have completed the normal pre-operative work up including nutritional counseling, psychological evaluation, and all necessary studies to rule out other co-morbid conditions prior to surgery. Patients have metabolic syndrome.
Interventions
Patients wishing to participate in the research will complete all necessary pre-operative work-up labs, testing \& counseling, complete and sign the informed consent. During weight loss surgery a small amount of subcutaneous and omental fat will be collected for analysis, with subsequent blood collection post surgery for analysis.
Eligibility Criteria
Patients who present for bariatric surgery to treat morbid obesity.
You may qualify if:
- Meet NIH Criteria for Bariatric Surgery
- Between the Age of 18-55
- Dyslipidemia controlled with medication
- Impaired glucose metabolism or type 2 diabetes
You may not qualify if:
- Uncontrolled Metabolic syndrome (uncontrolled diabetes, htn, dyslipidemia), one or all conditions.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
University of California Davis Medical Center
Sacramento, California, 95817, United States
Related Links
Biospecimen
Blood, urine, feces, liver, adipose tissue, GI tissue
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Mohamed R Ali, MD
University of California Davis Health System
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
December 25, 2013
First Posted
December 31, 2013
Study Start
February 1, 2011
Primary Completion (Estimated)
April 1, 2035
Study Completion (Estimated)
April 1, 2035
Last Updated
May 18, 2026
Record last verified: 2026-05