Evaluation of Objective Perimetry Using Chromatic Multifocal Pupillometer
Objective Perimetry in Normal Subjects,Glaucoma Patients and Retinal Dystrophy Patients
1 other identifier
observational
200
1 country
1
Brief Summary
Objective perimetry can better monitor visual field defects in retinal dystrophy and Glaucoma patients than conventional subjective perimetry. The PLR ( Pupil Light Reflex to short and long wavelength stimuli should be significantly lower compared to healthy participants in areas of visual field defects in retinal dystrophy and Glaucoma patients.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Dec 2013
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
December 1, 2013
CompletedFirst Submitted
Initial submission to the registry
December 12, 2013
CompletedFirst Posted
Study publicly available on registry
December 18, 2013
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2026
ExpectedStudy Completion
Last participant's last visit for all outcomes
December 31, 2026
April 25, 2024
April 1, 2024
13.1 years
December 12, 2013
April 24, 2024
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
PLR response amplitude and latency
single visit
Study Arms (2)
Healthy subjects
Healthy subjects will be used as control group
Patients
Patients with Glaucoma , Patients with retinal dystrophy
Eligibility Criteria
Two Groups: 1. Control, 2. Patients - Glaucoma patients with early damage (nasal step) of Humphrey visual field (HVF), Glaucoma patients with advanced damage of HVF (arcuate , tubular vision) and retinal dystrophy patientsl
You may qualify if:
- Age 18-80 years old.
- Signing informed consent.
- Pupillary reflex to light.
You may not qualify if:
- Cloudy corneas.
- Surgical intraocular ophthalmic procedure within the past 30 days.
- No reactive pupils.
- Synechia of the iris to the lens after surgery or inflammation.
- Neovascularization.
- Axenfeld-Rieger Syndrome.
- Iris atrophy (ICE syndrome).
- Iris coloboma.
- Sphincter damage due to ischemia.
- Sphincter damage due to trauma (tears of sphincter or diffuse damage to muscle).
- Sphincter damage due to Herpes Zoster Uveitis.
- Sphincter damage due to high intraocular pressure.
- Iris tumor or cyst.
- Ectropion uvae.
- Adie's pupil.
- +5 more criteria
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Sheba Medical Center
Tel Litwinsky, 52621, Israel
Related Publications (1)
Skaat A, Sher I, Kolker A, Elyasiv S, Rosenfeld E, Mhajna M, Melamed S, Belkin M, Rotenstreich Y. Pupillometer-based objective chromatic perimetry in normal eyes and patients with retinal photoreceptor dystrophies. Invest Ophthalmol Vis Sci. 2013 Apr 17;54(4):2761-70. doi: 10.1167/iovs.12-11127.
PMID: 23482470BACKGROUND
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER GOV
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Head of Electrophisiology Unit, Maurice and Gabriela Goldschleger Eye Research Institute
Study Record Dates
First Submitted
December 12, 2013
First Posted
December 18, 2013
Study Start
December 1, 2013
Primary Completion (Estimated)
December 31, 2026
Study Completion (Estimated)
December 31, 2026
Last Updated
April 25, 2024
Record last verified: 2024-04