Predicting Cognitive Resilience Against Sleep Loss

NCT01651429 | Completed

• 1 other identifier: D12AP00241
• Study Type: interventional
• Target: 48
• Locations: 1 country
• Sites: 1

Brief Summary

Resilience is the ability to cope effectively and adapt to a wide range of stressful environmental challenges. Sleep loss has been shown to reduce activity in the brain regions responsible for resilience. The ability to resist the effects of sleep loss appears to be a stable, trait-like quality. This study will attempt to predict individuals' trait-resistance to sleep loss based on their neurobiology.

Conditions

Sleep Deprivation

Keywords

Sleep Deprivation

Outcome Measures

Primary Outcomes (1)

• Differences in the medial prefrontal cortex (MPFC) as measured by fMRI, DTI, and MRS

  It is hypothesized that, relative to vulnerable individuals, those who are highly resistant to the adverse effects of sleep loss on cognition will show: 1) increased gray matter volume in the MPFC, 2) greater white matter integrity as indicated by the Diffusion Tensor Imaging measure of fractional anisotropy (FA) values in the MPFC, 3) greater functional activation in MPFC during cognitively demanding tasks, 4) greater functional connectivity between MPFC and alerting regions of the midbrain and thalamus; and 5) different ratios of GABA and glutamate within the MPFC.

  Session 2 of study (1 week after enrollment)

Secondary Outcomes (1)

• Psychomotor Vigilance Task (PVT)

  At sleep deprivation session (2 weeks after enrollment)

Other Outcomes (1)

• Karolinska Sleepiness Scale (KSS)

  At sleep deprivation session (2 weeks after enrollment)

Study Arms (1)

Sleep deprivation

EXPERIMENTAL

Participants will undergo 29 hours of sleep deprivation, 17 of which will be spent in the laboratory.

Behavioral: Sleep deprivation

Interventions

Sleep deprivation BEHAVIORAL

Participants will undergo 29 hours of sleep deprivation. They will wake up at 7:00 am on the day of the study and remain awake in the laboratory until 12:00 pm the next day.

Sleep deprivation

Eligibility Criteria

• Age: 20 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Age 20-45 years
• Right handedness as assessed by the Edinburgh Handedness Inventory
• For women: regular menstrual cycles (duration between 25 and 35 days with no more than 3 day variation between cycle)

You may not qualify if:

• History of head injury with loss of consciousness or post-traumatic amnesia, or major neurological illness
• Medical or neurologic condition that would confound interpretation of results, including alcohol or drug abuse/dependence in the past 6 months, neurological disorders including any history of seizures
• History of cardiac problems
• History of major depressive disorder or anxiety disorder
• Lifetime history of psychotic disorder, including bipolar disorder, schizophrenia, or obsessive compulsive disorder
• Other DSM-IV diagnosis that could affect interpretation of results
• Mixed or left handedness
• Abnormal visual acuity that cannot be corrected by contact lenses
• Daily caffeine use exceeding 400 mg per day
• History of smoking or tobacco use in the past year
• Metal within the body, pregnancy, or other contraindication for MRI procedures
• Use of drugs or medications that could affect functional neuroimaging results (e.g., fluoxetine, beta-blockers)
• Psychotropic medication use within the past 6 weeks

Sponsors & Collaborators

• Mclean Hospital: lead

Study Sites (1)

McLean Hospital

Belmont, Massachusetts, 02478, United States

Location

MeSH Terms

Conditions

Sleep Deprivation

Condition Hierarchy (Ancestors)

Dyssomnias; Sleep Wake Disorders; Nervous System Diseases; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Mental Disorders

Study Officials

• William D Killgore, PhD

  Mclean Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: SCREENING
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: July 23, 2012
• First Posted: July 27, 2012
• Study Start: April 1, 2013
• Primary Completion: June 1, 2014
• Study Completion: June 1, 2014
• Last Updated: June 16, 2014

Record last verified: 2014-06

Locations

US (1)