Effect of Sleep Restriction on Decision Making and Inflammation

NCT01989741 | Completed

• 1 other identifier: 2012-A00399-34
• Study Type: interventional
• Target: 12
• Locations: 1 country
• Sites: 1

Brief Summary

• hypothesis: sleep restriction in healthy subject trigger alteration of decision making associated with immuno-inflammatory changes
• inclusion criterias: healthy subjects, men, under 35 years, BMI\<26, no sleep troubles, intermediate chronotype
• design: 12 subjects, longitudinal study 2 days of baseline, 7 night of sleep restriction (4h sleep/night), recovery (1, 2, 3 and 9 normal sleep nights).
• parameters: decision making tests, reaction time, wakefulness test, biological parameters (cathecholamines, pro-inflammatory cytokines...), heart rate, blood pressure
• control of sleep restriction: continuous polysomnographic survey

Conditions

Sleep Deprivation

Keywords

sleep restriction, decision making, wakefullness

Outcome Measures

Primary Outcomes (1)

• London tower test score (décision making)

  % of good score and mean response time resulting from London Tower test, assessed during baseline, sleep restriction (day 1 to day 5) and recovery (day 1 to day 3) at 10 AM

  up to 3 days

Secondary Outcomes (3)

• wakefulness

  maintenance of wakefulness test (MWT) score observed every day during baselline, sleep restriction and recovery at 09 AM, 12 AM, 4 PM and 7 PM

• cognitive function

  up to 3 days

• Inflammation

  biological marker of inflammation levels assessed every day during baseline, sleep restriction and recovery at 08 AM

Study Arms (1)

sleep restriction

OTHER

Longitudinal study of response to sleep restriction. Comparison between baseline values and sleep restriction values

Other: Sleep restriction

Interventions

Sleep restriction OTHER

4 hours sleep by night during one week

sleep restriction

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• healthy men, \< 35 yr old, BMI\<26, intermediate chronotype

You may not qualify if:

• sleep trouble, acute or chronique disease (cardiological, neurological...), women

Sponsors & Collaborators

• Institut de Recherche Biomedicale des Armees: lead

Study Sites (1)

Institut de recherche biomédicale des armées

Brétigny-sur-Orge, 91223, France

Location

Related Publications (2)

• Rabat A, Gomez-Merino D, Roca-Paixao L, Bougard C, Van Beers P, Dispersyn G, Guillard M, Bourrilhon C, Drogou C, Arnal PJ, Sauvet F, Leger D, Chennaoui M. Differential Kinetics in Alteration and Recovery of Cognitive Processes from a Chronic Sleep Restriction in Young Healthy Men. Front Behav Neurosci. 2016 May 23;10:95. doi: 10.3389/fnbeh.2016.00095. eCollection 2016.

  PMID: 27242464 DERIVED

• Sauvet F, Drogou C, Bougard C, Arnal PJ, Dispersyn G, Bourrilhon C, Rabat A, Van Beers P, Gomez-Merino D, Faraut B, Leger D, Chennaoui M. Vascular response to 1 week of sleep restriction in healthy subjects. A metabolic response? Int J Cardiol. 2015;190:246-55. doi: 10.1016/j.ijcard.2015.04.119. Epub 2015 Apr 16.

  PMID: 25932797 DERIVED

MeSH Terms

Conditions

Sleep Deprivation

Condition Hierarchy (Ancestors)

Dyssomnias; Sleep Wake Disorders; Nervous System Diseases; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Mental Disorders

Study Officials

• Fabien SAUVET, MD, PhD

  Institut de recherche biomédicale des armées

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: médecin principal (MD, PhD)

Study Record Dates

• First Submitted: January 12, 2013
• First Posted: November 21, 2013
• Study Start: September 1, 2012
• Primary Completion: December 1, 2012
• Study Completion: December 1, 2012
• Last Updated: November 21, 2013

Record last verified: 2013-11

Locations

FR (1)