Sleep Restriction and Energy Expenditure

NCT01751581 | Completed

• 1 other identifier: SLR-P&F-1
• Study Type: interventional
• Target: 10
• Locations: 1 country
• Sites: 1

Brief Summary

Each 4-day period will follow the same protocol. Basically, for the entire study, we will prepare all of the subject's food and will require him or her to eat all of the food that we give at the times we tell them to eat. The subject will arrive at the hospital on the evening of day 1, and become inpatients. On day 2, the subject will be permitted to leave the hospital campus under the supervision of the research staff. On day 3, they will be required to stay in a small room called a metabolic chamber for 24 hours. This room measures how many calories you burn in one day. On day 4, we will measure the subject's energy expenditure in response to a breakfast meal. They will be given breakfast and the number of calories that they burn after that meal will be measured over a 6-hour period. Then the subject will be discharged at the end of the test. The 2 study periods will differ only in bedtimes and wakeup times. During one period, the subject will go to bed at 1 am and wake up at 5 am and during the other period they will go to bed at 11 pm and wake up at 7 am.

Conditions

Obesity

Keywords

Obesity; Resting Metabolic Rate; Sleep; Eating

Outcome Measures

Primary Outcomes (1)

• Resting Metabolic Rate

  Metabolic rate from 11 pm on day 2 until 7 am on the morning of day 4 will be measured in a metabolic chamber. The metabolic chamber is an air-tight room (22,000 l volume) equipped with a bed, chair, desk, television, VCR, telephone, treadmill, sink and toilet. All meals and snacks will be served at the scheduled time. Subjects will be asked to perform 30 min of light physical activity at 1500 h and 2030 h. Physical activity will consist of 30 min of cycling at 12 mi/h. Bedtimes will be the same as the previous night and actigraph monitoring will be used to confirm compliance with the sleep protocol. Women will exit the chamber at 0700 h the following day.

  32 hours

Secondary Outcomes (1)

• Post Prandial Energy Expenditure and Thermic Effect of Food

  8 hours on day 4

Study Arms (2)

Habitual Sleep

ACTIVE COMPARATOR

Women sleep 8 h/night throughout the study phase

Behavioral: Habitual sleep

Short Sleep

EXPERIMENTAL

Women sleep 4 h/night throughout the study phase

Behavioral: Short Sleep

Interventions

Short Sleep BEHAVIORAL

Participants will be restricted in sleep and only allowed to sleep from 1 am to 5 am.

Short Sleep

Habitual sleep BEHAVIORAL

Participants sleep 8 h/night throughout the study phase (from 11 pm to 7 am)

Habitual Sleep

Eligibility Criteria

• Age: 21 Years - 45 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Age 21-45 yrs
• Non-pregnant, non-lactating female subjects
• Body mass index (BMI) 25-28 kg/m2
• Weight stable (± 2.5 kg) for at least 3 mo prior to evaluation
• If a woman of child-bearing potential, must be willing to adhere to an acceptable form of contraception
• Non-smoker
• Regularly sleeps 7-8.5 hours/night

You may not qualify if:

• Diabetes, uncontrolled hypertension
• Attempted to lose weight in past 3 months
• Eating disorder
• Stroke, seizure disorder, or other significant neurological disease;
• HIV positive by self-report
• Unstable or uncontrolled medical illness including active malignancies within past 5 yrs
• Untreated or unstable hypothyroidism
• Hyperthyroidism
• A score on the Brief Psychiatric Inventory that exceeds the 90th percentile;
• Subjects with psychoses, bipolar disorder, major depression, severe personality disorders, suicidal
• Alcohol or substance abuse in the past 6 mo
• Pregnant, planning pregnancy in the next 6 mo, or breast-feeding
• Participating in a commercial diet or behavior modification program (e.g., Weight Watchers), or plans to participate
• Shift worker, commercial long-distance driver, heavy equipment operator, history of drowsy driving
• Takes naps regularly

Sponsors & Collaborators

• St. Luke's-Roosevelt Hospital Center: lead

Study Sites (1)

St. Luke's Hospital

New York, New York, 10026, United States

Location

Related Publications (1)

• Shechter A, Rising R, Albu JB, St-Onge MP. Experimental sleep curtailment causes wake-dependent increases in 24-h energy expenditure as measured by whole-room indirect calorimetry. Am J Clin Nutr. 2013 Dec;98(6):1433-9. doi: 10.3945/ajcn.113.069427. Epub 2013 Oct 2.

  PMID: 24088722 DERIVED

MeSH Terms

Conditions

Obesity

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Marie-Pierre St. Onge, PhD

  St. Luke's Roosevelt Hospital/Columbia University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 6, 2012
• First Posted: December 18, 2012
• Study Start: November 1, 2011
• Primary Completion: December 1, 2012
• Study Completion: April 1, 2013
• Last Updated: August 2, 2013

Record last verified: 2011-12

Locations

US (1)