NCT01948674

Brief Summary

The purpose of this study is to see if computer tasks that challenge the brain (cognitively stimulating tasks) can improve memory and other types of thinking in adolescents and young adults who are being treated for substance use problems. The study will compare the effects of different versions of the computer tasks.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
87

participants targeted

Target at P50-P75 for phase_2

Timeline
Completed

Started Oct 2013

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

September 17, 2013

Completed
6 days until next milestone

First Posted

Study publicly available on registry

September 23, 2013

Completed
8 days until next milestone

Study Start

First participant enrolled

October 1, 2013

Completed
1.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 1, 2015

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

August 1, 2015

Completed
Last Updated

August 24, 2016

Status Verified

August 1, 2016

Enrollment Period

1.8 years

First QC Date

September 17, 2013

Last Update Submit

August 22, 2016

Conditions

Outcome Measures

Primary Outcomes (1)

  • working memory (change from baseline)

    expected within 2 weeks after intervention

Secondary Outcomes (7)

  • timeline follow back (change from baseline)

    expected within 2 weeks after intervention

  • delay discounting (change from baseline)

    expected within 2 weeks after intervention

  • Stroop (change from baseline)

    expected within 2 weeks after intervention

  • reading comprehension (change from baseline)

    expected within 2 weeks after intervention

  • emotion regulation (change from baseline)

    expected within 2 weeks after intervention

  • +2 more secondary outcomes

Study Arms (2)

computerized tasks- adaptive

EXPERIMENTAL
Behavioral: Computerized tasks

computerized tasks - nonadaptive

ACTIVE COMPARATOR
Behavioral: Computerized tasks

Interventions

The study will compare the effects of different methods of computerized mental stimulation. The intervention involves 25 sessions involving computerized cognitive tasks.

computerized tasks - nonadaptivecomputerized tasks- adaptive

Eligibility Criteria

Age14 Years - 21 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64)

You may qualify if:

  • age 14-21
  • Diagnosis of substance use disorder (SUD) by DSM-IV criteria with marijuana as primary substance of abuse
  • eligible for intensive outpatient treatment

You may not qualify if:

  • Untreated psychiatric disorder that might make participation hazardous
  • Any condition associated with severe cognitive impairment

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Mountain Manor Treatment Center

Baltimore, Maryland, 21229, United States

Location

MeSH Terms

Conditions

Substance-Related Disorders

Condition Hierarchy (Ancestors)

Chemically-Induced DisordersMental Disorders

Study Officials

  • Matthew W Johnson, PhD

    Johns Hopkins University

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
phase 2
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
FACTORIAL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Associate Professor

Study Record Dates

First Submitted

September 17, 2013

First Posted

September 23, 2013

Study Start

October 1, 2013

Primary Completion

August 1, 2015

Study Completion

August 1, 2015

Last Updated

August 24, 2016

Record last verified: 2016-08

Locations