Cognitive Stimulation
Effects of Cognitive Training in Methadone Maintenance Patients
2 other identifiers
interventional
134
1 country
1
Brief Summary
This research is being done to learn if computer tasks that challenge the brain (cognitively stimulating tasks) can improve memory and other types of thinking. The study will compare the effects of different versions of the computer tasks. It also will compare the task performance of different groups of people.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_2
Started Dec 2010
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
December 1, 2010
CompletedFirst Submitted
Initial submission to the registry
January 5, 2011
CompletedFirst Posted
Study publicly available on registry
January 6, 2011
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 1, 2013
CompletedStudy Completion
Last participant's last visit for all outcomes
July 1, 2013
CompletedResults Posted
Study results publicly available
March 7, 2014
CompletedApril 16, 2014
March 1, 2014
2.6 years
January 5, 2011
November 23, 2013
March 25, 2014
Conditions
Outcome Measures
Primary Outcomes (1)
Working Memory
Change in maximum number of digits correctly recalled in Digit Span Backwards task, from baseline to 7 weeks
baseline, 7 weeks
Secondary Outcomes (6)
Episodic Memory
baseline, 7 weeks
Trail-making
baseline, 7 weeks
go/No-go
baseline, 7 weeks
Addiction Severity Index
baseline, 7 weeks
Delay Discounting
baseline, 7 weeks
- +1 more secondary outcomes
Study Arms (2)
Adaptive cognitively stimulating activities
EXPERIMENTALNon-adaptive cognitively stimulating activities
ACTIVE COMPARATORInterventions
The study will compare the effects of different methods of computerized mental stimulation. The intervention involves 25 sessions involving computerized cognitive tasks.
Eligibility Criteria
You may qualify if:
- age 18-55
- in methadone maintenance or healthy volunteers
- healthy
You may not qualify if:
- Axis I disorder (except substance abuse and dependence in methadone maintenance patients)
- severe cognitive impairment
- serious untreated medical condition
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Johns Hopkins Universitylead
- National Institute on Drug Abuse (NIDA)collaborator
Study Sites (1)
BPRU, Johns Hopkins Bayview Medical Center
Baltimore, Maryland, 21224, United States
Related Publications (1)
Rass O, Schacht RL, Buckheit K, Johnson MW, Strain EC, Mintzer MZ. A randomized controlled trial of the effects of working memory training in methadone maintenance patients. Drug Alcohol Depend. 2015 Nov 1;156:38-46. doi: 10.1016/j.drugalcdep.2015.08.012. Epub 2015 Aug 24.
PMID: 26404954DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Results Point of Contact
- Title
- Dr. Miriam Mintzer
- Organization
- Johns Hopkins University School of Medicine
Study Officials
- PRINCIPAL INVESTIGATOR
Miriam Z Mintzer, PhD
Johns Hopkins University
Publication Agreements
- PI is Sponsor Employee
- Yes
Study Design
- Study Type
- interventional
- Phase
- phase 2
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Associate Professor
Study Record Dates
First Submitted
January 5, 2011
First Posted
January 6, 2011
Study Start
December 1, 2010
Primary Completion
July 1, 2013
Study Completion
July 1, 2013
Last Updated
April 16, 2014
Results First Posted
March 7, 2014
Record last verified: 2014-03