NCT02063984

Brief Summary

This study will continue research designed to improve treatment outcomes for adolescent substance use disorders by integrating neuroscience- and behaviorally-based treatments. In particular, this project will be the first to evaluate whether Working Memory Training can enhance cognitive function and reduce impulsive decision making to improve abstinence outcomes. In addition, an adaptive abstinence-based incentive program will be evaluated as a new method for intervening with those who do not respond to their first-line treatment.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
59

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Nov 2013

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

November 1, 2013

Completed
3 months until next milestone

First Submitted

Initial submission to the registry

February 13, 2014

Completed
4 days until next milestone

First Posted

Study publicly available on registry

February 17, 2014

Completed
4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 1, 2018

Completed
6 months until next milestone

Study Completion

Last participant's last visit for all outcomes

August 14, 2018

Completed
2.7 years until next milestone

Results Posted

Study results publicly available

May 10, 2021

Completed
Last Updated

June 4, 2021

Status Verified

May 1, 2021

Enrollment Period

4.3 years

First QC Date

February 13, 2014

Results QC Date

April 14, 2021

Last Update Submit

May 9, 2021

Conditions

Substance Use Disorders

Outcome Measures

Primary Outcomes (2)

  • Any Cannabis Abstinence

    Number of participants with any cannabis abstinence during treatment

    Intervention weeks 1 to 14

  • Weeks of Continuous Cannabis Abstinence

    Weeks of continuous abstinence during treatment

    14 week treatment period

Secondary Outcomes (4)

  • Any Days of Cannabis Use

    Intervention weeks 1 to 14

  • Days of Cannabis Use

    The intervention period between Week 1 and Week 14

  • Any Cannabis Abstinence Across Four Treatment Strategies

    Treatment period between week 1 and week 14

  • Weeks of Cannabis Abstinence Across Four Treatment Strategies

    Treatment period between week 1 and week 14

Study Arms (2)

Intensive Outpatient Treatment (IOP) + Contingency Management (CM) + Working Memory Training (WMT)

EXPERIMENTAL

IOP + CM + WMT

Behavioral: Intensive Outpatient Treatment (IOP) + Contingency Management (CM)Behavioral: Working Memory Training

IOP + CM

ACTIVE COMPARATOR

IOP + CM

Behavioral: Intensive Outpatient Treatment (IOP) + Contingency Management (CM)

Interventions

Intensive Outpatient Treatment (IOP) + Contingency Management (CM)BEHAVIORAL

Multiple group sessions weekly, one individual counseling session weekly with teen to review and discuss contingency management abstinence-based incentives

IOP + CMIntensive Outpatient Treatment (IOP) + Contingency Management (CM) + Working Memory Training (WMT)
Working Memory TrainingBEHAVIORAL

25 computer-delivered sessions of neurocognitive training

Also known as: Cogmed, Inc
Intensive Outpatient Treatment (IOP) + Contingency Management (CM) + Working Memory Training (WMT)

Eligibility Criteria

Age12 Years - 26 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64)

You may qualify if:

  • Participants must be 12 to 26 years of age, must live at home with the parent who will participate, report using marijuana during the previous 30 days or provide a marijuana-positive urine test, meet criteria for cannabis abuse or dependence, and have a parent who can participate.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Mountain Manor Treatment Center

Baltimore, Maryland, 21229, United States

Location

Related Publications (1)

  • Stanger C, Scherer EA, Vo HT, Babbin SF, Knapp AA, McKay JR, Budney AJ. Working memory training and high magnitude incentives for youth cannabis use: A SMART pilot trial. Psychol Addict Behav. 2020 Feb;34(1):31-39. doi: 10.1037/adb0000480. Epub 2019 Jun 27.

    PMID: 31246068RESULT

MeSH Terms

Conditions

Substance-Related Disorders

Condition Hierarchy (Ancestors)

Chemically-Induced DisordersMental Disorders

Results Point of Contact

Title
Alan J. Budney, Ph.D
Organization
Geisel School of Medicine at Dartmouth Center for Technology and Behavioral Health
alan.budney@dartmouth.edu
603-646-7088

Study Officials

  • Alan J Budney, Ph.D

    Dartmouth College

    PRINCIPAL INVESTIGATOR

Publication Agreements

PI is Sponsor Employee
No
Restrictive Agreement
No

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

February 13, 2014

First Posted

February 17, 2014

Study Start

November 1, 2013

Primary Completion

February 1, 2018

Study Completion

August 14, 2018

Last Updated

June 4, 2021

Results First Posted

May 10, 2021

Record last verified: 2021-05

Locations

US(1)