Resource Use and Disease Course in Dementia (REDIC)

NCT01920100 | Completed

• 1 other identifier: E13237
• Study Type: observational
• Target: 696
• Locations: 1 country
• Sites: 3

Brief Summary

This project is based on a three-year program that aims to improve the knowledge of the socioeconomic consequences of dementia in Norway. By including patients with and without dementia in four different cohorts (from nursing homes, from memory clinics, home-dwelling persons with dementia and elderly persons without dementia), the project's aim is to describe the course of dementia, the economical cost of dementia and to look into possible risk factors for dementia.

Conditions

Neurodegenerative Diseases; Dementia

Keywords

Health Care Costs; Genetic Polymorphism

Outcome Measures

Primary Outcomes (1)

• Cost of dementia

  The cost of dementia is assessed with the Resource Utilization in Dementia (RUD) (Wimo et al. 2009), for a period of three years for all the four cohorts. The nursing home cohort is assessed at baseline and every 6 month for three years, the other three cohorts are assessed three times over a three-year follow up period.

  3 years

Secondary Outcomes (5)

• The course of neuropsychiatric symptoms

  3 years

• Quality of Life in persons admitted to nursing homes

  3 years

• Prescription of medication

  3 years

• DNA polymorphism

  At baseline

• Organizational factors of the nursing homes

  At baseline

Study Arms (4)

Memory clinic

People visiting a memory clinic at Ullevål University Hospital, St Olav Hospital or Innlandet Hospital Trust (n=400). The patients will be assessed three times over a three-year follow-up. Baseline inclusion started in January 2010. The final assessments will take place in spring 2014.

Nursing homes

People admitted to a nursing home recruited from municipalities in Hedmark, Oppland, Nord-Trøndelag and Bergen (n=1000). Baseline assessments take place when the person is admitted to the nursing home. The patients will be assessed every six months over a three-year follow-up period. The first participant was included in March 2012, and baseline inclusion will be completed in December 2013.

In-home care

People 70 years of age or older receiving in-home care recruited from municipalities in Hedmark, Oppland, Oslo, Østfold and Buskerud (n=995). The patients will be assessed three times over a three-year follow-up period. Baseline inclusion started in April 2009 and the final assessments will take place in December 2013.

People without dementia

People without dementia recruited from Nord-Trøndelag, Drammen and Oslo (n=400). The participants will be assessed three times over a three-year follow-up period. Baseline inclusion will take place in autumn 2012 and the last follow-up will take place in autumn 2015.

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Nursing home Memory clinics In-home care Persons without dementia (Control)

You may qualify if:

• All patients examined at a memory clinic with mild cognitive impairment or mild dementia

You may not qualify if:

• None
• In-home care sample
• Persons 70 years of age or older receiving in-home care from the municipality
• None
• Nursing-home sample
• All persons admitted to the nursing home with an expected stay of more than four weeks.
• Participants should be 65 years or older, unless established dementia disease, in which case younger persons also will be included
• Life expectancy of less than six weeks
• Control sample
• Persons 65 years or older without any sign of dementia
• None

Sponsors & Collaborators

• Sykehuset Innlandet HF: lead
• Norwegian Directorate of Health: collaborator
• King's College London: collaborator
• Karolinska Institutet: collaborator
• Oslo University Hospital: collaborator
• University Hospital, Akershus: collaborator
• Helse Midt-Norge: collaborator
• Norwegian University of Science and Technology: collaborator
• University of Bergen: collaborator
• Norwegian Centre for Ageing and Health: collaborator

Study Sites (3)

University of Bergen

Bergen, Norway

Location

Senter for omsorgsforskning - Midt

Namsos, Norway

Location

Innlandet Hospital Trust

Ottestad, 2512, Norway

Location

Related Publications (3)

• Sandvik RKNM, Husebo BS, Selbaek G, Strand G, Patrascu M, Mustafa M, Bergh S. Oral symptoms in dying nursing home patients. Results from the prospective REDIC study. BMC Oral Health. 2024 Jan 25;24(1):129. doi: 10.1186/s12903-024-03901-x.

  PMID: 38273300 DERIVED

• Callegari E, Saltyte Benth J, Selbaek G, Gronnerod C, Bergh S. Do prescription rates of psychotropic drugs change over three years from nursing home admission? BMC Geriatr. 2021 Sep 16;21(1):496. doi: 10.1186/s12877-021-02437-x.

  PMID: 34530728 DERIVED

• Sandvik RK, Selbaek G, Bergh S, Aarsland D, Husebo BS. Signs of Imminent Dying and Change in Symptom Intensity During Pharmacological Treatment in Dying Nursing Home Patients: A Prospective Trajectory Study. J Am Med Dir Assoc. 2016 Sep 1;17(9):821-7. doi: 10.1016/j.jamda.2016.05.006. Epub 2016 Jun 16.

  PMID: 27321869 DERIVED

Related Links

• Link to web page with a working paper describing the project

Biospecimen

Retention: SAMPLES WITH DNA

DNA samples are collected by mouth swabs from persons recruited from nursing homes.

MeSH Terms

Conditions

Neurodegenerative Diseases; Dementia

Condition Hierarchy (Ancestors)

Nervous System Diseases; Brain Diseases; Central Nervous System Diseases; Neurocognitive Disorders; Mental Disorders

Study Officials

• Geir Selbaek, pHd

  Centre for old age psychiatry research, Innlandet Hospital Trust

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 5, 2013
• First Posted: August 9, 2013
• Study Start: April 1, 2009
• Primary Completion: January 1, 2015
• Study Completion: November 1, 2023
• Last Updated: November 24, 2023

Record last verified: 2023-11

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF

Locations

NO (3)