Prevalence and Level of Diagnosis of Dementia in a Population-based Sample in the County of Trøndelag

NCT04289389 | Completed

• 1 other identifier: 181124
• Study Type: observational
• Target: 11,675
• Locations: 1 country
• Sites: 1

Brief Summary

To investigate and make valid estimates of the occurrence of dementia and the most common subtypes of dementia in Trøndelag, and transfer these figures to estimates of the occurrence of dementia in Norway as a whole, by age, sex and severity of dementia. Furthermore, the proportion of people without dementia diagnosis among those with dementia will be examined. The investigators will further investigate whether there are differences in dementia prevalence between males and females and educational groups and look at factors associated with a lack of diagnosis.

Conditions

Dementia

Keywords

Prevalence; Epidemiology; Alzheimer's disease

Outcome Measures

Primary Outcomes (1)

• Dementia criteria in DSM-5

  Used to assess prevalence of dementia in the study population

  Each participant is evaluated against dementia criteria in DSM- after participation, based on assessment done in the 20 month long assessment period

Secondary Outcomes (8)

• Montreal Cognitive Assessment

  Each participant were assessed once during an assessment period of 20 months

• CERAD Ten-word test

  Each participant is assessed once during an assessment period of 20 months

• Severe Impairment Battery

  Participants in institution with known moderate to severe dementia is assessed once during an assessment period of 20 months

• Hospital Anxiety and Depression Scale

  Each participant is assessed once during an assessment period of 20 months.

• Instrumental Activities in Daily Living Scale

  Assessed in proxy interview during interview period of 22 months

Study Arms (2)

HUNT4 70+

All inhabitants in Nord-Trøndelag 70 years of age and older were invited.

HUNT4 Trondheim 70+

All inhabitants of one district in Trondheim 70 years of age and older were invited.

Eligibility Criteria

• Age: 70 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Persons of 70 years of age or older participated in HUNT4 and accepted cognitive screening in HUNT4 70+.

You may qualify if:

• Living in the designated area

You may not qualify if:

• None

Sponsors & Collaborators

• Norwegian Centre for Ageing and Health: lead
• University of Oslo: collaborator
• Norwegian Health Association: collaborator

Study Sites (1)

Norwegian National Advisory Unit on Ageing and Health

Tønsberg, Norway

Location

Related Publications (4)

• Engedal K, Gjora L, Benth JS, Wagle J, Ronqvist TK, Selbaek G. The Montreal Cognitive Assessment: Normative Data from a Large, Population-Based Sample of Cognitive Healthy Older Adults in Norway-The HUNT Study. J Alzheimers Dis. 2022;86(2):589-599. doi: 10.3233/JAD-215442.

  PMID: 35094994 BACKGROUND

• Gjora L, Strand BH, Engedal K, Ernstsen L, Myrstad C, Skjellegrind H, Thingstad P, Selbaek G. Dementia and mild cognitive impairment in older people in Trondelag. Tidsskr Nor Laegeforen. 2023 Jun 26;143(10). doi: 10.4045/tidsskr.22.0815. Print 2023 Jun 27. English, Norwegian.

  PMID: 37376934 BACKGROUND

• Wagle J, Selbaek G, Benth JS, Gjora L, Ronqvist TK, Bekkhus-Wetterberg P, Persson K, Engedal K. The CERAD Word List Memory Test: Normative Data Based on a Norwegian Population-Based Sample of Healthy Older Adults 70 Years and Above. The HUNT Study. J Alzheimers Dis. 2023;91(1):321-343. doi: 10.3233/JAD-220672.

  PMID: 36404547 BACKGROUND

• GjOra L, Strand BH, Bergh S, Borza T, Braekhus A, Engedal K, Johannessen A, Kvello-Alme M, Krokstad S, Livingston G, Matthews FE, Myrstad C, Skjellegrind H, Thingstad P, Aakhus E, Aam S, Selbaek G. Current and Future Prevalence Estimates of Mild Cognitive Impairment, Dementia, and Its Subtypes in a Population-Based Sample of People 70 Years and Older in Norway: The HUNT Study. J Alzheimers Dis. 2021;79(3):1213-1226. doi: 10.3233/JAD-201275.

  PMID: 33427745 RESULT

Related Links

• Website that shows the current and future prevalence of dementia in the different regions and municipalities in Norway

MeSH Terms

Conditions

Dementia; Alzheimer Disease

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Neurocognitive Disorders; Mental Disorders; Tauopathies; Neurodegenerative Diseases

Study Officials

• Geir Selbæk, PhD

  Norwegian National Advisory Unit on Ageing and Health

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 6, 2020
• First Posted: February 28, 2020
• Study Start: January 1, 2018
• Primary Completion: April 7, 2026
• Study Completion: April 7, 2026
• Last Updated: April 13, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

NO (1)