Cognitive Behavioural Therapy of Early Dementia

NCT00735046 | Completed DMC

• 1 other identifier: KOR-683-KUR-0000-I
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

A randomized, controlled, parallel-group trial to evaluate the efficacy of a cognitive behavioral therapy for patients with early dementia.

Conditions

Dementia

Keywords

Early dementia in Alzheimer's disease (MMSE ≥ 21)

Outcome Measures

Primary Outcomes (1)

• Functional ability in the everyday context

  Baseline, post treatment, 6 months post treatment

Secondary Outcomes (1)

• Quality of life, depression, neuro-psychiatric symptoms

  Same as for primary outcome

Study Arms (2)

1

Intervention

Behavioral: Cognitive behavioral therapy for early Alzheimer's disease

2

control

Other: Control

Interventions

Cognitive behavioral therapy for early Alzheimer's disease BEHAVIORAL

12 weekly individual sessions, total duration 3 months, regular involvement of patient's proxy ever second session. Intervention is manualized but is flexible with regard to individual resources and needs.

1

Control OTHER

Patients and proxies who are assigned to treatment as usual

2

Eligibility Criteria

• Age: 18 Years - 95 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients referred to memory clinics and specialist (psychiatrist, neurologist) offices

You may qualify if:

• Mild dementia (MMSE \> 21) in Alzheimer's disease (ICD-10), proxy available

You may not qualify if:

• Acute of unstable psychiatric or physical disease, proxy unavailable
• Participation in another trial

Sponsors & Collaborators

• Technical University of Munich: lead
• University of Leipzig: collaborator
• Zentralinstitut für Seelische Gesundheit Mannheim: collaborator
• Humboldt-Universität zu Berlin: collaborator

Study Sites (1)

Prof. Dr. A. Kurz, Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technische Universitaet Muenchen

Munich, Bavaria, 81675, Germany

Location

Related Publications (3)

• Kliegel M, Eschen A, Thone-Otto AI. Planning and realization of complex intentions in traumatic brain injury and normal aging. Brain Cogn. 2004 Oct;56(1):43-54. doi: 10.1016/j.bandc.2004.05.005.

  PMID: 15380875 BACKGROUND

• Werheid K, Thone-Otto AI. [Cognitive training in Alzheimer's dementia]. Nervenarzt. 2006 May;77(5):549-57. doi: 10.1007/s00115-005-1998-2. German.

  PMID: 16228161 BACKGROUND

• Kurz A, Pohl C, Ramsenthaler M, Sorg C. Cognitive rehabilitation in patients with mild cognitive impairment. Int J Geriatr Psychiatry. 2009 Feb;24(2):163-8. doi: 10.1002/gps.2086.

  PMID: 18636436 BACKGROUND

Biospecimen

Retention: NONE RETAINED

not required

MeSH Terms

Conditions

Dementia

Interventions

Cognitive Behavioral Therapy

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Neurocognitive Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Behavior Therapy; Psychotherapy; Behavioral Disciplines and Activities

Study Officials

• Alexander Kurz, MD

  Klinikum rechts der Isar

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: August 13, 2008
• First Posted: August 14, 2008
• Study Start: April 1, 2008
• Study Completion: April 1, 2010
• Last Updated: January 14, 2011

Record last verified: 2008-07

Locations

DE (1)