Auditory Verbal Hallucinations in Schizophrenia

NCT01886417 | Completed

• 2 other identifiers: 09062009-A00248-49
• Study Type: observational
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

Auditory verbal hallucinations (AVHs) are speech perceptions in the absence of a relevant external stimulation. Some accounts of AVHs claim that a deficit in inner speech monitoring would cause the verbal thoughts of the patient to be perceived as external voices resulting in AVHs. In order to examine whether AVHs correspond to self-generated inner speech, the present study aims at collecting speech muscle activity during covert AVHs (without articulation), overt speech and rest. Surface electromyography (sEMG) is used on schizophrenia patients and control subjects to detect any speech muscle activity during AVH.

Conditions

Schizophrenia

Outcome Measures

Primary Outcomes (1)

• Labial EMG activity during auditory verbal hallucination

  up to 3 years

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

in- and out-patients

You may qualify if:

• Healthy controls:
• must be more than 18 years and less than 60 years old
• must have signed consent form
• must be able to read stimuli on a screen
• Schizophrenia patients:
• must be more than 18 years and less than 60 years old
• must have signed consent form
• must be able to read stimuli on a screen
• diagnosed with a schizophrenia disorder according to DSM-IV TR (diagnostic and statistical of mental disorders) (PANSS item P3 greater than 4)
• prior evaluation of the secondary effects of any medication via Barnes and AIMS scales
• affiliated with the French social security
• if under guardianship, must have additional consent form signed by guardian

You may not qualify if:

• Healthy controls:
• if aged less than 18 years or more than 60 years
• diagnosed with any psychiatric disorder
• with any language disorder (aphasia, SLI, dysarthria, stuttering, etc.)
• with auditory impairment
• pregnant, parturient, breast-feeding
• Schizophrenia patients:
• if aged less than 18 years or more than 60 years
• significant secondary effects of antipsychotic medication, measured with the Barnes and AIMS scales
• with a neurodegenerative disease
• with any language disorder (aphasia, SLI, dysarthria, stuttering, etc.)
• with auditory impairment
• pregnant, parturient, breast-feeding

Sponsors & Collaborators

• University Hospital, Grenoble: lead
• GIPSA-LAB: collaborator

Study Sites (1)

University Hospital of Grenoble

Grenoble, 38043, France

Location

MeSH Terms

Conditions

Schizophrenia

Condition Hierarchy (Ancestors)

Schizophrenia Spectrum and Other Psychotic Disorders; Mental Disorders

Study Officials

• Thierry BOUGEROL, MD, PHD, HDR

  University Hospital of Grenoble, France

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 21, 2013
• First Posted: June 25, 2013
• Study Start: October 1, 2009
• Primary Completion: March 1, 2015
• Study Completion: March 1, 2015
• Last Updated: March 10, 2015

Record last verified: 2015-03

Locations

FR (1)