Effects of Standing on Glycemia in Prediabetic Adults

NCT01884792 | Completed

• 1 other identifier: 1208M18741
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

The study is a crossover, pilot trial examining the acute effects of standing on blood sugar in prediabetic, working adults. Participants will complete oral glucose tolerance testing, once while sitting and once while standing. They will also wear a continuous blood sugar monitor once while sitting at their desk for a week and once while using their desk as a sit-stand desk with a goal of standing intermittently for at least half of the work day. Physical activity levels will be measured with an accelerometer. The primary study hypothesis is that blood sugar will differ between the sitting and standing conditions for each of the tests performed.

Conditions

Prediabetes

Keywords

prediabetes; physical inactivity; sedentary; standing

Outcome Measures

Primary Outcomes (1)

• Blood sugar area under the curve

  The area under the curve following the 2 hour blood sugar tests.

  2 hours

Secondary Outcomes (1)

• Accelerometer counts

  4 hours and 2 5 day periods

Study Arms (4)

Sitting Oral Glucose Tolerance Test

PLACEBO COMPARATOR

An OGTT is performed while the subject sits at their desk for the entire 2-hour period. 5 blood sugar measurements are taken and a 75g dextrose beverage is consumed following the first, baseline blood sugar reading. The blood sugar is then measured every 30 minutes up to 120 min.

Other: Sitting OGTT; Other: Standing OGTT

Standing Oral Glucose Tolerance Test

EXPERIMENTAL

The participant stands at their desk for the duration of the 2-hour blood sugar test. The same procedure is performed as in the sitting condition.

Other: Sitting OGTT; Other: Standing OGTT

Sitting Continuous Glucose Monitor

PLACEBO COMPARATOR

A continuous blood glucose monitor is worn for 5 days while at work. In the sitting condition the participant only sits at their desk for the duration of the week. Blood sugar is monitored 4 times per day to calibrate the CGM and an accelerometer is worn to track physical activity.

Other: Sitting CGM; Other: Standing CGM

Standing Continuous Glucose Monitor

EXPERIMENTAL

Participants are instructed to stand intermittently for at least half of their work day during this 5 day period. Blood sugar is monitored and physical activity is tracked with an accelerometer.

Other: Sitting CGM; Other: Standing CGM

Interventions

Sitting OGTT OTHER

Sitting Oral Glucose Tolerance Test; Standing Oral Glucose Tolerance Test

Standing OGTT OTHER

Sitting Oral Glucose Tolerance Test; Standing Oral Glucose Tolerance Test

Sitting CGM OTHER

Sitting Continuous Glucose Monitor; Standing Continuous Glucose Monitor

Standing CGM OTHER

Sitting Continuous Glucose Monitor; Standing Continuous Glucose Monitor

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Fasting blood glucose \>100 mg/dl
• Employed full-time working at least 35 hours/week
• Able to safely begin a light physical activity program

You may not qualify if:

• Heart disease
• Renal disease
• Peripheral neuropathy
• Retinopathy
• PAD
• Lower limb amputation
• pregnancy
• active substance abuse
• current smoker
• psychiatric disorder
• severe visual impairment
• immune-compromised individuals,
• enrollment in a physical activity study
• use of insulin or an insulin pump

Sponsors & Collaborators

• University of Minnesota: lead
• Mayo Clinic: collaborator

Study Sites (1)

Department of Human Services

Saint Paul, Minnesota, 55155, United States

Location

MeSH Terms

Conditions

Prediabetic State; Sedentary Behavior

Condition Hierarchy (Ancestors)

Diabetes Mellitus; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases; Behavior

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 19, 2013
• First Posted: June 24, 2013
• Study Start: March 1, 2013
• Primary Completion: July 1, 2013
• Study Completion: September 1, 2013
• Last Updated: September 15, 2014

Record last verified: 2014-09

Locations

US (1)