Glycemic Effects of Honey
1 other identifier
interventional
55
1 country
1
Brief Summary
Honey has been used as a sweetener for centuries. Recent data indicate that honey consumption may have beneficial effects upon glucose intolerance, a health issue currently affecting 57 million Americans of every age and ethnicity. In order to evaluate the glycemic effect of honey, the investigators will carry out a human trial assessing biomarkers of blood glucose responses, insulin sensitivity, oxidative stress, and inflammatory markers. Our primary objective is to determine the glycemic effects of honey in comparison to sucrose and high fructose corn syrup (HFCS). The investigators hypothesize that honey will promote improved glucose tolerance and insulin sensitivity compared to both sucrose and high fructose corn syrup in normal glycemic and glucose intolerant adults.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Jun 2011
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
June 1, 2011
CompletedFirst Submitted
Initial submission to the registry
June 3, 2011
CompletedFirst Posted
Study publicly available on registry
June 10, 2011
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2014
CompletedStudy Completion
Last participant's last visit for all outcomes
August 1, 2015
CompletedAugust 3, 2018
August 1, 2018
3.5 years
June 3, 2011
August 1, 2018
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Area under the curve glucose, response for OGTT. Glucose-120 min OGTT-AUC
Evaluation of the effect of the treatment nutritive sweeteners on glucose tolerance.
15 weeks
Secondary Outcomes (5)
Insulin- 120 min OGTT - AUC
15 weeks
Triglycerides - 120 min OGTT - AUC
15 weeks
Inflammatory Markers
15 weeks
Oxidative Stress Markers
15 weeks
Serum Lipids
15 weeks
Study Arms (3)
Honey
ACTIVE COMPARATOR60.7 grams daily orally times 14 days
CHO
ACTIVE COMPARATOR50 grams daily orally times 14 days
High Fructose Corn Syrup
ACTIVE COMPARATOR65.7 grams daily orally times 14 days
Interventions
Eligibility Criteria
You may qualify if:
- Men and women between 20-80 years of age.
- Normal Glucose Tolerance
- Fasting glucose between ≤105 mg/dl
- Normal body weight or overweight (BMI 18-29.9)
- Impaired Glucose Tolerance
- Fasting glucose between 106-125 mg/dl
- Overweight or obese (BMI 25 - 39.9)
- Willingness to comply with the demands of the experimental protocol
- Sedentary Lifestyle
You may not qualify if:
- Known uncontrolled disease process
- Diabetes mellitus
- Use of medications that affect glucose metabolism
- History of an eating disorder
- Pregnancy or breast feeding
- Inability to give consent
- Unwillingness or inability to consume the supplemental sugars
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Grand Forks Human Nutrition Research Center
Grand Forks, North Dakota, 58201, United States
Related Publications (6)
Bantle JP, Raatz SK, Thomas W, Georgopoulos A. Effects of dietary fructose on plasma lipids in healthy subjects. Am J Clin Nutr. 2000 Nov;72(5):1128-34. doi: 10.1093/ajcn/72.5.1128.
PMID: 11063439BACKGROUNDMathern JR, Raatz SK, Thomas W, Slavin JL. Effect of fenugreek fiber on satiety, blood glucose and insulin response and energy intake in obese subjects. Phytother Res. 2009 Nov;23(11):1543-8. doi: 10.1002/ptr.2795.
PMID: 19353539BACKGROUNDRaatz SK, Torkelson CJ, Redmon JB, Reck KP, Kwong CA, Swanson JE, Liu C, Thomas W, Bantle JP. Reduced glycemic index and glycemic load diets do not increase the effects of energy restriction on weight loss and insulin sensitivity in obese men and women. J Nutr. 2005 Oct;135(10):2387-91. doi: 10.1093/jn/135.10.2387.
PMID: 16177201BACKGROUNDShah M, Adams-Huet B, Bantle JP, Henry RR, Griver KA, Raatz SK, Brinkley LJ, Reaven GM, Garg A. Effect of a high-carbohydrate versus a high--cis-monounsaturated fat diet on blood pressure in patients with type 2 diabetes. Diabetes Care. 2005 Nov;28(11):2607-12. doi: 10.2337/diacare.28.11.2607.
PMID: 16249527BACKGROUNDAndreozzi F, Laratta E, Procopio C, Hribal ML, Sciacqua A, Perticone M, Miele C, Perticone F, Sesti G. Interleukin-6 impairs the insulin signaling pathway, promoting production of nitric oxide in human umbilical vein endothelial cells. Mol Cell Biol. 2007 Mar;27(6):2372-83. doi: 10.1128/MCB.01340-06. Epub 2007 Jan 22.
PMID: 17242212BACKGROUNDRaatz SK, Johnson LK, Picklo MJ. Consumption of Honey, Sucrose, and High-Fructose Corn Syrup Produces Similar Metabolic Effects in Glucose-Tolerant and -Intolerant Individuals. J Nutr. 2015 Oct;145(10):2265-72. doi: 10.3945/jn.115.218016. Epub 2015 Sep 2.
PMID: 26338891DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Susan K. Raatz, PhD., RD
Agriculture Research Service, United States Department of Agriculture, Grand Forks Human Nutrition Research Center
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NON RANDOMIZED
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- CROSSOVER
- Sponsor Type
- FED
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
June 3, 2011
First Posted
June 10, 2011
Study Start
June 1, 2011
Primary Completion
December 1, 2014
Study Completion
August 1, 2015
Last Updated
August 3, 2018
Record last verified: 2018-08