Omega-6 to Omega-3 Fatty Acid Ratio and Higher Order Cognitive Function in 7-to 9-year-olds

NCT01823419 | Completed

• 1 other identifier: 10-1401
• Study Type: observational
• Target: 70
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to investigate the role of the ratio of omega-6 to omega-3 fatty acids on executive functions. The investigators hypothesize that participants ages 7-9 years with a ratio closer to 4:1 will do better on tests of executive function than participants with a ratio closer to the purported Western diet norm of 15:1.

Conditions

Typical Development

Outcome Measures

Primary Outcomes (1)

• Relation between executive function and n-6/n-3 fatty acid intake

  Executive function will be measured using a validated and standardized system known as CANTAB (Cambridge Neuropsychological Test Automated Battery) and correlated with the ratio of fatty acid intake. 24-hour diet recalls will be completed using the NDSR (Nutrient Data System for Research) software. Across one week, the children will be interviewed 3 times (two weekdays, one weekend day) about what they ate in the previous 24 hours. The dietary data will be averaged to arrive at the n-6/n-3 intake. The children will then come to lab for one visit where they will be assessed using the CANTAB.

  up to 10 days

Secondary Outcomes (2)

• Temperament

  Baseline

• Socioeconomic status

  Baseline

Study Arms (1)

7-9 year olds

Typically developing 7- to 9-year-olds will be enrolled and tested.

Eligibility Criteria

• Age: 7 Years - 9 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

7-9 year olds

You may qualify if:

• typically-developing

You may not qualify if:

• not fluent in English

Sponsors & Collaborators

• University of North Carolina, Chapel Hill: lead

Study Sites (1)

UNC at Chapel Hill Nutrition Research Institute

Kannapolis, North Carolina, 28081, United States

Location

Related Publications (2)

• Sheppard KW, Cheatham CL. Omega-6/omega-3 fatty acid intake of children and older adults in the U.S.: dietary intake in comparison to current dietary recommendations and the Healthy Eating Index. Lipids Health Dis. 2018 Mar 9;17(1):43. doi: 10.1186/s12944-018-0693-9.

  PMID: 29523147 DERIVED

• Sheppard KW, Cheatham CL. Omega-6 to omega-3 fatty acid ratio and higher-order cognitive functions in 7- to 9-y-olds: a cross-sectional study. Am J Clin Nutr. 2013 Sep;98(3):659-67. doi: 10.3945/ajcn.113.058719. Epub 2013 Jul 3.

  PMID: 23824723 DERIVED

Biospecimen

Retention: NONE RETAINED

No biospecimens will be collected.

Study Officials

• Carol L Cheatham, PhD

  UNC-Chapel Hill

  PRINCIPAL INVESTIGATOR

• Kelly W Sheppard, BS

  UNC-Chapel Hill

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: March 20, 2013
• First Posted: April 4, 2013
• Study Start: October 1, 2010
• Primary Completion: August 1, 2011
• Study Completion: August 1, 2011
• Last Updated: April 4, 2013

Record last verified: 2013-03

Locations

US (1)