Exploration of the Social Cognition in Adolescents With a Dissociative Disorder or Autism Spectrum

NCT01805128 | Completed

• 1 other identifier: 12-AOI-04
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 3

Brief Summary

The schizophrenic disorders and pervasive developmental disorders are neurodevelopmental disorders distinct origin who share common challenges to engage and maintain social relationships and mutual disturbances of affective contact. An important issue of research is to determine the cognitive and brain mechanisms underlying social disability in these two pathologies. Several lines of social cognition have been systematically explored: the perception of emotions, the ability to attribute intentionality and mental states to others (theory of mind), the understanding of social situations in different contexts. We made the observation today that research findings clearly in the field of autism and schizophrenic disorders that converge on common patterns neurocognitive abnormalities. Consequently, many programs support published today use the same therapeutic targets and the same tools in both pathologies. This raises two questions of science: (1) whether the disorders of social cognition reported in the field of autism and schizophrenia are "specific deficit" and not "specific condition", that is to say they are inherent social disadvantage whatever condition or (2) if these disorders of social cognition is a pattern common to autism and schizophrenia but are the result of specific neurocognitive mechanisms and different in each these pathologies. Systematic exploration of these issues is a current issue for understanding the pathophysiological borders between the two neurodevelopmental disorders but also to better define the potential targets of therapeutic strategies, psycho-educational and remediation of disorders of social cognition in autism and schizophrenia. Main objective: To compare clinical cognitive profiles in adolescents with a schizophrenic disorder, autistic or healthy in the three areas of social cognition: perception of emotions, attribution of intentions to others (theory of mind) and style attribution. We shall constitute three population groups of patients, a group of patients meeting the diagnosis of schizophrenia, a group of patients with autism and a control group (healthy subjects).

Conditions

Autistic Disorder; Schizophrenia

Keywords

Schizophrenia; Autistic Disorder; social cognition

Outcome Measures

Primary Outcomes (1)

• Compare cognitive profiles in clinical adolescents with a schizophrenic disorder, autistic or healthy in the three areas of social cognition

  Compare cognitive profiles in clinical adolescents with a schizophrenic disorder, autistic or healthy in the three areas of social cognition: the perception of emotions, attribution of intentions to others (theory of mind) and style attribution. We will study the brain evoked potentials during the execution of the task of facial emotion recognition.

  First day

Secondary Outcomes (2)

• Compare the cognitive profiles within the clinical group of schizophrenic

  First day

• Cognitive profiles compare clinical results between the different types of schizophrenia and autism patients.

  First day

Study Arms (3)

schizophrenia

EXPERIMENTAL

child with a DSM-IV diagnosis of schizophrenia

Other: Facial recognition of emotions; Other: understanding metaphors; Other: Attribution of intentionality to others in social situations depending on the type of situation

autism spectrum disorder

EXPERIMENTAL

child with a DSM-IV diagnosis of autism spectrum disorder

Other: Facial recognition of emotions; Other: understanding metaphors; Other: Attribution of intentionality to others in social situations depending on the type of situation

Healthy

EXPERIMENTAL

child having no DSM-IV diagnosis of schizophrenia spectrum disorder or autism

Other: Facial recognition of emotions; Other: understanding metaphors; Other: Attribution of intentionality to others in social situations depending on the type of situation

Interventions

Facial recognition of emotions OTHER

The purpose is to consider the recognition of emotions expressed on face in patients with a schizophrenic disorder, autism and in healthy subjects.

Healthy; autism spectrum disorder; schizophrenia

understanding metaphors OTHER

Explore understanding of figurative language, including metaphor, in schizophrenic patients, autistic and healthy, and well understand how patients develop an interpretation from access to speaker's communicative intentionality (theory mind).

Healthy; autism spectrum disorder; schizophrenia

Attribution of intentionality to others in social situations depending on the type of situation OTHER

Compare the style of attribution of intentions in three populations of subjects: schizophrenic, autistic and healthy.

Healthy; autism spectrum disorder; schizophrenia

Eligibility Criteria

• Age: 12 Years - 18 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• Child with a DSM-IV diagnosis of schizophrenia or autism spectrum disorder:
• Schizophrenic patients, positive to the award of psychosis section of the Kiddie SADS and having a negative ADI.
• or:
• Patients with autism spectrum disorder, diagnosed by the scale ADI (Autism Diagnostic Interview) or ADOS (Autism Diagnostic Observation Schedule): Autism Asperger and PDD nos. These patients do not respond to a diagnosis of psychosis Kiddie-SADS according.
• Total IQ greater than or equal to 70

You may not qualify if:

• Genetic disorders, neurological and neurosensory
• Child satisfy both the diagnosis of autism spectrum disorder and schizophrenia than (comorbidity).
• Will not be included patients who participate in a study on rehabilitation for social skills.

Sponsors & Collaborators

• Centre Hospitalier d'Antibes Juans les Pins: collaborator
• Centre Hospitalier de Cannes: collaborator
• Centre Hospitalier Universitaire de Nice: lead

Study Sites (3)

Centre Hospitalier d'Antibes Juans les Pins

Antibes, 06600, France

Location

Centre hospitalier de Cannes

Cannes, 06400, France

Location

CHU de Nice

Nice, 06000, France

Location

Related Publications (1)

• Bonnard-Couton V, Lubrano S, Tosello AL, Serret S, Askenazy-Gittard F. [Autism spectrum disorders, a pilot parent-child unit]. Soins Pediatr Pueric. 2018 Nov-Dec;39(305):37-41. doi: 10.1016/j.spp.2018.09.010. French.

  PMID: 30449399 RESULT

MeSH Terms

Conditions

Schizophrenia; Autistic Disorder

Condition Hierarchy (Ancestors)

Schizophrenia Spectrum and Other Psychotic Disorders; Mental Disorders; Autism Spectrum Disorder; Child Development Disorders, Pervasive; Neurodevelopmental Disorders

Study Officials

• Emmanuelle DOR, Medical Doctor

  Centre Hospitalier Universitaire de Nice

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 22, 2013
• First Posted: March 6, 2013
• Study Start: January 1, 2013
• Primary Completion: April 1, 2013
• Study Completion: May 1, 2013
• Last Updated: March 31, 2026

Record last verified: 2026-03

Locations

FR (3)