NCT01801488

Brief Summary

Test single nucleotide polymorphisms (SNP's) in ruptured and unruptured aneurysm tissue to identify a genetic difference between the two types of aneurysms; and to test SNP's in arteriovenous malformation tissue to identify a genetic link.

Trial Health

35
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
5

participants targeted

Target at below P25 for all trials

Geographic Reach
1 country

1 active site

Status
terminated

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

November 1, 2011

Completed
1.1 years until next milestone

First Submitted

Initial submission to the registry

December 12, 2012

Completed
3 months until next milestone

First Posted

Study publicly available on registry

February 28, 2013

Completed
1 year until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 1, 2014

Completed
Last Updated

November 25, 2015

Status Verified

February 1, 2013

Enrollment Period

2.3 years

First QC Date

December 12, 2012

Last Update Submit

November 24, 2015

Conditions

Arteriovenous MalformationsIntracranial AneurysmSubarachnoid Hemorrhage

Outcome Measures

Primary Outcomes (1)

  • Risk gene expression

    The samples will be frozen after collection and then analyzed.

    Within one week of sample collection.

Study Arms (3)

AVM Patients

Patients receiving surgical intervention for an intracranial arterial-venous malformation.

Ruptured Aneurysm

Patients receiving surgical intervention for a ruptured intracranial aneurysm.

Unruptured Aneurysm

Patients receiving surgical intervention for an unruptured intracranial aneurysm.

Eligibility Criteria

Age18 Years - 89 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Patients admitted to University Hospital.

You may qualify if:

  • All adult patients between the ages of 18 and 89 that are having open surgical resection of an AVM or clipping of an aneurysm will be included

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

SUNY Upstate Medical University

Syracuse, New York, 13210, United States

Location

Biospecimen

Retention: SAMPLES WITH DNA

Tissue samples of intracranial arterial-venous malformations (AVM) or aneurysm and blood samples.

MeSH Terms

Conditions

Arteriovenous MalformationsIntracranial AneurysmSubarachnoid Hemorrhage

Condition Hierarchy (Ancestors)

Vascular MalformationsCardiovascular AbnormalitiesCardiovascular DiseasesVascular DiseasesCongenital AbnormalitiesCongenital, Hereditary, and Neonatal Diseases and AbnormalitiesIntracranial Arterial DiseasesCerebrovascular DisordersBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesAneurysmIntracranial HemorrhagesHemorrhagePathologic ProcessesPathological Conditions, Signs and Symptoms

Study Officials

  • Eric M Deshaies, MD

    SUNY Upstate Medical University Neurosurgery

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
CASE CONTROL
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

December 12, 2012

First Posted

February 28, 2013

Study Start

November 1, 2011

Primary Completion

March 1, 2014

Last Updated

November 25, 2015

Record last verified: 2013-02

Locations

US(1)