Role of Proteomics and Metallomics in Cerebral Vasospasm Following Subarachnoid Hemorrhage

NCT01799018 | Completed

• 1 other identifier: IRB#225490
• Study Type: observational
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to determine the role of Proteomics and Metallomics in Cerebral Vasospasm following Subarachnoid Hemorrhage

Conditions

Subarachnoid Hemorrhage; Cerebral Vasospasm; Hydrocephalus

Keywords

Xanthine Oxidase; Cerebrospinal fluid

Outcome Measures

Primary Outcomes (2)

• Protein identification and concentration

  For the duration of CSF drainage, or until the 21st day after admission.

• Metal ion identification and concentration

  For the duration of CSF drainage, or until the 21st day after admission.

Study Arms (2)

SAH Patients

Patients admitted with the diagnosis of aneurismal subarachnoid hemorrhage (SAH) and cerebral angiogram negative SAH who would need to have the external ventricular drain (EVD) placed for the management of hydrocephalus.

Control Patients

Patients with non-hemorrhagic brain pathology such as posterior fossa tumor or stroke who will have the CSF sampling for diagnostic or therapeutic purposes.

Eligibility Criteria

• Age: 18 Years - 89 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients admitted to University Hospital.

You may qualify if:

• Non traumatic SAH documented by CT scan
• Patient with SAH who would need external ventricular drain (EVD) for the management of hydrocephalus
• Patients with normal pressure Hydrocephalus that require an external drain
• Control (non - hemorrhagic) group - CSF collected from patients with posterior fossa tumor or stroke with EVD in place for the management of hydrocephalus.

You may not qualify if:

• Recent infection within last 1 month of presentation- can increase inflammatory markers
• Recent surgery or acute myocardial infarction within last 1 month of presentation
• Age \> 89 years or \< 18 years

Sponsors & Collaborators

• State University of New York - Upstate Medical University: lead

Study Sites (1)

State University of New York Upstate Medical University

Syracuse, New York, 13210, United States

Location

Biospecimen

Retention: SAMPLES WITH DNA

Cerebrospinal Fluid (CSF)

MeSH Terms

Conditions

Subarachnoid Hemorrhage; Vasospasm, Intracranial; Hydrocephalus

Condition Hierarchy (Ancestors)

Intracranial Hemorrhages; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Hemorrhage; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Eric M Deshaies, MD

  SUNY Upstate Medical University - Neurosurgery

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 12, 2012
• First Posted: February 26, 2013
• Study Start: April 1, 2011
• Primary Completion: June 1, 2013
• Study Completion: June 1, 2013
• Last Updated: November 20, 2014

Record last verified: 2014-11

Locations

US (1)