Familial Intracranial Aneurysm Study II
2 other identifiers
observational
5,875
1 country
16
Brief Summary
The purposes of this study are to identify possible genes that may increase the risk of aneurysm development in the brain, and to determine the effect of environmental factors such as cigarette smoking and high blood pressure on the expression of these genes.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Sep 2002
Longer than P75 for all trials
16 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 1, 2002
CompletedFirst Submitted
Initial submission to the registry
October 28, 2003
CompletedFirst Posted
Study publicly available on registry
October 29, 2003
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 1, 2015
CompletedStudy Completion
Last participant's last visit for all outcomes
May 1, 2015
CompletedAugust 18, 2015
August 1, 2015
12.7 years
October 28, 2003
August 17, 2015
Conditions
Keywords
Study Arms (1)
1
475 families with multiple affected family members (phase I) 200 families with multiple affected family members (phase II) 1800 subjects with sporadic intracranial aneurysms
Eligibility Criteria
475 families with multiple affected family members will be selected in this collaborative research effort of neurologists and neurosurgeons throughout the United States, Canada, Australia and New Zealand (completed during phase I) 200 Families with multiple affected family members located in North America, and an additional 1800 subjects with sporadic aneurysm without a qualifing family history.
You may qualify if:
- To be eligible to participate in this study, families must have two or more affected pairs of siblings (brothers/sisters) or 3 or more family members affected with intracerebral aneurysms.
- Sporadic aneurysm subjects must have a confirmed aneurysm.
You may not qualify if:
- A history of polycystic kidney disease, Marfan's Syndrome, Ehlers Danlos Syndrome, or fibromuscular dysplasia.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (16)
University of Alabama
Birmingham, Alabama, 35294, United States
University of California,
San Francisco, California, 94143-0114, United States
University of Florida
Gainesville, Florida, 32610-0265, United States
Indianapolis Neurosurgical Group
Indianapolis, Indiana, 46202, United States
University of Maryland
Baltimore, Maryland, 21201-1595, United States
Johns Hopkins University School of Medicine
Baltimore, Maryland, 21287, United States
Massachusetts General Hospital
Boston, Massachusetts, 02114-2698, United States
Brigham & Women's Hospital
Boston, Massachusetts, 02115, United States
University of Michigan
Ann Arbor, Michigan, 48109-0489, United States
Mayo Clinic
Rochester, Minnesota, 55905, United States
Washington University
St Louis, Missouri, 63110, United States
Columbia University,
New York, New York, 10032, United States
University of Cincinnati, Department of Neurology
Cincinnati, Ohio, 45267, United States
Allegheny General Hospital
Pittsburgh, Pennsylvania, 15212, United States
University of Virginia
Charlottesville, Virginia, 22903, United States
University of Washington
Seattle, Washington, 98104, United States
Related Publications (1)
Sauerbeck L, Hornung R, Woo D, Moomaw CJ, Anderson C, Connolly ES, Rouleau GA, Brown RD Jr, Broderick JP; FIA Study Investigators. Mortality and causes of death in the Familial Intracranial Aneurysm study. Int J Stroke. 2013 Dec;8(8):696-700. doi: 10.1111/j.1747-4949.2012.00857.x. Epub 2012 Aug 29.
PMID: 22928607DERIVED
Biospecimen
blood sample
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Joseph P. Broderick, M.D.
University of Cincinnati
Study Design
- Study Type
- observational
- Observational Model
- FAMILY BASED
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Joseph P. Broderick
Study Record Dates
First Submitted
October 28, 2003
First Posted
October 29, 2003
Study Start
September 1, 2002
Primary Completion
May 1, 2015
Study Completion
May 1, 2015
Last Updated
August 18, 2015
Record last verified: 2015-08